Ahhh thanks guys also I figured you meant acetyl l carnitine hcl, I will give that a go opposed to food grade hcl I’m probably over thinking it all but just want good quality ingredients to the best I can in the product. I wanted to add taurine but don’t want to play around to much with isotonic of the solution just yet.
MESO-Rx
Anabolic Steroids
Help brewing L carnitine
- Thread starter Katelove99
- Start date
When you say turned out well what ph level did you end up with?
6-6.5
It's going to be hypertonic at any concentration about 50mg/ml.
At 500mg/ml it's highly hypertonic
Photon
Member
Yes and alot of us are doing 500-700mg/ml daily for months, years with no pip.
I use it almost daily at 500mg/ml as well. Is there some sort of damage being done to the tissue? I don't know
To make the L carnintine more isotonic I’ve read NaCL (sodium chloride) is very effective
Or you could use Glycine
My magnetic mixer comes this week and I’m going to give this recipe a try unless any of you have strong opinions about this recipe being bad.
-Lcarnintine base 25g
-Taurine 5g
-Sodium chloride .45g (help make it more isotonic)
-sodium citrate .10g (ph and buffer agent)
-citric acid .005g (ph and buffer agent)
-Benzyl alcohol .75ml
-sterile water 35ml initially just for displacement purposes then add remaining to get to 50ml
50ml multi use vial
500mg/ml L carnintine
100mg/ml taurine
Aiming for a ph level between 6.5 and 7
This will be my first time making L carnintine so we will see how it goes.
Or you could use Glycine
My magnetic mixer comes this week and I’m going to give this recipe a try unless any of you have strong opinions about this recipe being bad.
-Lcarnintine base 25g
-Taurine 5g
-Sodium chloride .45g (help make it more isotonic)
-sodium citrate .10g (ph and buffer agent)
-citric acid .005g (ph and buffer agent)
-Benzyl alcohol .75ml
-sterile water 35ml initially just for displacement purposes then add remaining to get to 50ml
50ml multi use vial
500mg/ml L carnintine
100mg/ml taurine
Aiming for a ph level between 6.5 and 7
This will be my first time making L carnintine so we will see how it goes.
I don't see the need for all that when just lcarn base ba and WFI works perfectly but have fun it's always nice to try new stuff
I agree with sampei, looks like a bit of over kill.
Unlike GSH , L-car is stable and doesn't need a buffer.
Also you can't make something that is hypertonic more isotonic by adding more substances to it. You can only to that by adding less or diluting it. That's why pharma comes in 200mg/ml and mixed with saline for iv drip
Photon
Member
Curious.
Why Taurine?
It's not gonna do much at that dose.
It has a pretty good oral absorbtion rate afaik.
I take like 10g via powder(oral) a day.
I personally think NAC is a good acid to use (oral absorption is like 10%).
However it degrades rapidly if your pH is not acidic, and it needs to be stored in the fridge.
Totally get that and know the recipe can be very simple, the sodium citrate and citric acid is just for adjusting ph if need be.
But the sodium chloride is to make it isotonic more so, being 500mgs/ml as everyone agrees is hypertonic so if you make it more isontonic this helps pip but more importantly reduce any tissue damage.
I mean I will give it go and let you all know.
Good point
The taurine is because like most things bioavailability isn’t the greatest orally.
The benefits of cellular hydration and the possibility enhanced insulin sensitivity.
It is a low dose and I’ve seen “recommendations” of 250mgs 3x/ week
And I really don’t mind injecting every day so I thought that would be adequate….. if I add more I believe it always makes things tougher for perfecting the solution to the best you can.
These are all things I appreciate hearing from you guys I’m just a newb trying to learn and am really interested in the process.
There is no pip...
HCL use is common. ALCAR HCL is also a good choice, L Carnitine HCL works and Glutathione can also be used !
So most of those are more natural considered options. I would like to use reduced glutathione to bring the ph
down but then I have to worry about it oxidizing much quicker?
I spoke to a pharmacist today about HCl for adjusting ph in injectable solutions and he seemed to think HCl was too strong and to use citric acid to lower ph. he said he would order me some.
This would be a better grade then just citric acid from pure bulk supplements.
I have similar concerns about glutathione but in my experience it seems to produce best results (low pip and knot) - provided you keep it in fridge or keep it frozen if you want to use it over long-term.
My second choice after glutathione is L Carnitine HCL.
ALCAR HCL is also good.
I usually have above three on hand so I use one of them.
HCL should be fine too - most pharma grade L-Carnitine uses HCL for PH adjustment. Its all about diluting it to right concentration and mixing in slowly. PH scale is logarithmic, as you lower PH you need exponentially more PH adjuster. It should be easy to dial in PH with HCL to somewhere around 6-6.5 range.
La
I’ve read all the threads here on L carnitine and the last question I have because it’s still unclear to me is tonicity/osmolarity. I get it if we dilute the mg/ml (so lower concentrated) we can get closer to body fluid. These numbers aren’t exact but let’s say body fluid is around 300 where 500mg/ml of L carnintine is upwards to 1200. Being this high leads to tissue damage is this something we are not really worried about?
Isotonic is around 300 mOsm
50mg/ml lcar is isotonic
500mg/ml is highly hypertonic at over 3000 mOsm
No idea about tissue damage, I would guess there would be some
There is no issue damage or one would have crippling pip god damn
