thejoker
Member
When powders are mixed, they reach a point of optimal uniformity after a certain time. If mixing continues beyond this optimal mix point, the blend can actually become worse, a phenomenon called over-mixing or segregation (demixing). This happens because differences in particle size/density cause the components of the mix to separate again, leading to poor API and excipient uniformity. That’s why mixing for time intervals and then testing the tablet at each interval (10 min, 20 min, 30 min etc.) is the best way to find the sweet spot for mix time. That is however extremely time consuming and expensive as you extrapolate that across dozens of products and then factor in some raw batches even for the same compound can have different density depending on the factory production method. Real Pharmaceutical companies have the resources for this, not UGLs.Janoshik tests as promised.
We will be getting a new supplier for Reta and Tirz as well as reducing our price as it is not close to what we are selling as.
Some of our orals also came in under and too much of a variance. It is a bit odd since we always overdose the raws by 10%+ and run most of them in a V blender for hours. It could be from low quality raws or too much of a variance of tablet sizes. We send in all raws to GetYourDrugsTested but they are only accurate within 5%. We may start sending in all raws to Jano to account for this.
We try to be transparent as possible and will send in further batches for testing.
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I’m surprised your number 1 custy and industry expert @william23kelly didn’t let you know about this.
