What do you mean with "fitness youtuber".
Could you give me some examples?
Because obviously i dont have "the look" to see it.
Because im wondering if this topic is overblown or not and in trying to understand it better. There is simply such huge discrepancy.
Some say "you need at least 8IU or a lot more than that over years to get acromegalia'" but then i read that casestudy of that guys that got acromegalia from 2 IU (over years).
Acromegaly has nothing to do with IU.
I’m going to try and break this down as simply as I can. Because despite not “personally” witnessing acromegalic changes, what I’m going to say is 100% certain, backed up with a mountain of evidence in medical literature building over the last 50 years.
If some decide acromegaly is a “myth”, “blown out of proportion”, or the classic “this doesn’t apply to me because the study subjects weren’t 43.5 year old 5’ 7” bodybuilders who injected rHGH between 7:12-7:19AM.” then IDGAF.
Suffer and don’t say you weren’t warned,
Acromegaly has nothing to do with IU.
It’s only caused by IGF-1. IGF regulates cellular growth. And we know people using the same IU have IGF-1 levels all over the place.
2iu doesn’t mean you’re safe, and 10iu doesn’t mean you’re at risk.
It’s all about the Z score, how far above you are normal IGF-1 for your age. Without fail even those with a pituitary tumor squeezing out a ton of growth hormone, when IGF-1 is knocked down with meds to normal appropriate levels, acromegaly stops progressing.
Specifically how far above the upper limit of normal you are FOR YOUR AGE.
Acromegaly is insidious. The average time to diagnosis is 7 years. 60% of the time it’s first identified by a DENTIST, EYE DOCTOR, or SLEEP APNEA SPECIALIST, since they’re trained to look for it.
The lowest Z score acromegaly is typically diagnosed at is 3.5.
It could take 2iu or 15iu to reach 3.5.
At a continuous Z 3.5:
Soft tissue always changes first. By 1 year at that level, your organs have changed sufficiently organomegaly can be seen on an MRI. Even the slowest moving acromegaly has unmistakable facial features an acromegaly specialist can visually identify after 12-24 months of Z 3.5, But almost no one else around you os likely to notice anything that sets off alarm bells. Maybe your shoes and rings don’t fit anymore so you catch it early.
But according to the experts, it’s not until someone who knows what to look for, like a dentist who notices your fucking teeth don’t line up anymore, identifies acromegaly after 7-10 years of elevated IGF-1. Imagine how much soft tissue has grown, how much your nose has changed, how many god damn whacks in the face with the ugly stick you must’ve gotten by the time your JAW EXPANDS.
Acromegaly doesn’t happen below Z 3. At least after an exhaustive review, I can’t find a single case of it below Z 3.
By Z 4 it’s almost always pathological. The higher above that the faster the changes come on.
So check your Z. If it’s above 3 and you keep it elevated like that for over 6-12 months, you’re probably developing acromegaly. Maybe very slowly at the lower. Over 4 and it’s nearly certain you’ll be fucked up after two years, including skeletal changes that may cause permanent joint issues.
That’s the main reason labs have an adult IGF Z score. Endocrinologists don’t really need them. It’s to give primary care doctors a simple number that automatically adjusts with age that tells them if the rHGH treatment adult patient they’re monitoring between endo appointments is slipping into the danger zone.
Keep Z below 3 if you’re using rHGH long term. Below 2 if you feel safer staying in the physiological range.
