Giant Semaglutide Thread (and other GLP-1 / GIP agonists)

[Doodle]

Wanted to create a thread where everyone can post their experiences with different sourced Semaglutide.

Who are you using?
Pharma vs non?
Dosage?
How long have you been taking it?
What are your thoughts?
Have you lost weight?
Side effects?
Oral vs injection?
Tests?

 

[lysos]

guys 10mg mounjaro e5d killed my appetite. Cant finish my chicken breast only can take protein yoghurts or protein bars. Its too much - have anyone good method to use aprox 7.5mg from 10mg kwikpen ?

 

[Hardcoreboy]

Does anyone have experience switching from 20mg tirz directly to retatrutide and what would be a good dosage?

 

[Svenderschreckliche]

guys 10mg mounjaro e5d killed my appetite. Cant finish my chicken breast only can take protein yoghurts or protein bars. Its too much - have anyone good method to use aprox 7.5mg from 10mg kwikpen ?

10 mg is 60 clicks if you make 45 clicks on the pen you have 7.5 mg

 

[The Answ3r]

How is sleep?

Yeah, sleep’s been really solid. Like deep, easy, no-issues sleep. I also switched from generic HGH to Sero, and if I remember right you’re into pharma HGH as well.

The only thing I’ve noticed is my resting heart rate is a bit higher now, around 80-90. I could add ivabradine again to bring it down, but then it becomes a pain to get my heart rate up into the 120-130 range during cardio. So for now I’m staying off it, and LISS is smooth, 60 minutes a day, heart rate climbs easily where I want it.

Does anyone have experience switching from 20mg tirz directly to retatrutide and what would be a good dosage?

I switched from 15mg Tirz to Reta. I started at 2mg just to feel it out and make sure sides were manageable, then slowly worked up to 6mg. So far, so good.

If you’re coming straight off 20mg Tirz, I’d still start low. Even if you tolerate GLP-1s well, Reta can feel different, and there’s no prize for rushing and getting wrecked by sides. Start at the minimum dose, see how you respond for a couple weeks, then titrate up if needed based on appetite, weight trend, and tolerability.

 

[Mariusdr]

Is anyone here worried about pancreatitis? Recently in the UK news sources are claiming GLP-1 agonists can result in acute pancreatitis

 

[The_Thinking_Elf]

Is anyone here worried about pancreatitis? Recently in the UK news sources are claiming GLP-1 agonists can result in acute pancreatitis

There is a very small sub-set of the population that have such a reaction to GLP-1s. You would know very quickly if that was the case (lab results wise) so you would need to discontinue the medication.

 

[Mariusdr]

There is a very small sub-set of the population that have such a reaction to GLP-1s. You would know very quickly if that was the case (lab results wise) so you would need to discontinue the medication.

Understood - so basically if you don’t experience this straight away you are good?

 

[The_Thinking_Elf]

Understood - so basically if you don’t experience this straight away you are good?

Generally, yes. One of the main diagnostic requirements for pancreatitis is upper abdominal pain (you would notice this yourself straight away). Lab tests would then confirm it but the pain would be quite noticeable.

 

[Mariusdr]

Generally, yes. One of the main diagnostic requirements for pancreatitis is upper abdominal pain (you would notice this yourself straight away). Lab tests would then confirm it but the pain would be quite noticeable.

Perfect - thank you!

Reason I was getting worried is that whenever I have a couple of drinks on GLP-1s I get insanely nauseous and feel basically poisoned. So was worried that was some kind of damage. Must just be the interplay between the 2 (will obviously not drink on them again)

 

[The_Thinking_Elf]

Perfect - thank you!

Reason I was getting worried is that whenever I have a couple of drinks on GLP-1s I get insanely nauseous and feel basically poisoned. So was worried that was some kind of damage. Must just be the interplay between the 2 (will obviously not drink on them again)

You do have to be a bit careful with alcohol while taking GLP-1s, but it mostly has to do with the potential combination of dehydration and low blood sugar levels.

 

[unid888]

Is anyone here worried about pancreatitis? Recently in the UK news sources are claiming GLP-1 agonists can result in acute pancreatitis

Be as healthy as possible, eat enough fats, do lots of cardio, don't rely on calorie restriction for extreme calorie deficits (1-2k+), and stay hydrated.

Calorie restriction is the main culprit imo, don't eat too little. If you can comfortably stay under 1k - 1,4k calories, your dose is too high.

All of this should ensure you don't have these issues.

Understood - so basically if you don’t experience this straight away you are good?

I don't think that's true at all, pancreatitis in most cases is going to be a cumulative effect.