Giant Semaglutide Thread (and other GLP-1 / GIP agonists)

[Doodle]

Wanted to create a thread where everyone can post their experiences with different sourced Semaglutide.

Who are you using?
Pharma vs non?
Dosage?
How long have you been taking it?
What are your thoughts?
Have you lost weight?
Side effects?
Oral vs injection?
Tests?

 

[Luke391]

I don't think you want to fuck with glucagon by throwing. together random compounds. Other glucagon drugs failed in early trials due to safety issues, You can't just increase it randomly and assume it's safe.

thanks. I'll up Tirz then and hope for the best

 

[newguy2]

Any recommendations on GLP insomnia? I had it terribly at the first titration with tirz, backed off and was able to sleep. Recently switched to Reta for the added benefits, started at 2.5mg and didn't get any help with hunger, a couple days later added 1mg more and every night since then I wake up around 2-3 and stay up for ever.

Every night I take 10mg of melatonin and last night I took 2.5 pills of unisom. Up from my usual 2. I only started taking these pills since sleep troubles from glp1's.

 

[phenominal34]

Any recommendations on GLP insomnia? I had it terribly at the first titration with tirz, backed off and was able to sleep. Recently switched to Reta for the added benefits, started at 2.5mg and didn't get any help with hunger, a couple days later added 1mg more and every night since then I wake up around 2-3 and stay up for ever.

Every night I take 10mg of melatonin and last night I took 2.5 pills of unisom. Up from my usual 2. I only started taking these pills since sleep troubles from glp1's.

Advil PM

 

[phenominal34]

thanks. I'll up Tirz then and hope for the best

You just gtta stick to something and stay with it, increase dose as needed or up cardio and weights. Pack on more muscle !! Muscle increases metabolism.

Every other day you’re wanting to experiment with this or that or change up this or that.

 

[newguy2]

Advil PM

Interersting. I am taking costco brand unisom which is the same ingredient in unisom sleeptabs. Looks like the advil have the same ingredient of unisom sleep gels. Wonder if it is much different.

 

[phenominal34]

Interersting. I am taking costco brand unisom which is the same ingredient in unisom sleeptabs. Looks like the advil have the same ingredient of unisom sleep gels. Wonder if it is much different.

For some reason it blows all others out of the water for me. Give it a go and let us know.

 

[newguy2]

For some reason it blows all others out of the water for me. Give it a go and let us know.

I'll check it out thanks

 

[Liter O' Test]

dont take anti histamines eto sleep theyll turn you retarded, figure out why you arnet sleeping

 

[The Answ3r]

Dropped Tirz from 15mg to 10mg and thought everything was smooth, but now I’m getting random nausea, especially in the mornings. For example, I’ll have breakfast, then slam my L-citrulline with some water 30-40 minutes later and suddenly I’m gagging like I just smelled ammonia caps. Same thing if I chug too much water during the day, my stomach acts like I tried to drown myself.

On top of that, I’ve been off HGH for about a month now and it feels like my blood sugar dips too low, which is a new kind of fun. Already did bloodwork and waiting on results to see what’s really going on. This whole thing is turning into a fun experiment, but hey, at least it keeps life interesting.

Update on my post: labs just came back. Glucose is 62 mg/dl, insulin is 2.3 uIU/ml, and A1c is 4.9. Both glucose and insulin are on the low side, but nothing dramatic. Tirz is still doing its job perfectly. If anyone here is struggling with insulin resistance, trust me, Tirz can pull you out of it the same way it did for me.

 

[Ghoul]

Any recommendations on GLP insomnia? I had it terribly at the first titration with tirz, backed off and was able to sleep. Recently switched to Reta for the added benefits, started at 2.5mg and didn't get any help with hunger, a couple days later added 1mg more and every night since then I wake up around 2-3 and stay up for ever.

Every night I take 10mg of melatonin and last night I took 2.5 pills of unisom. Up from my usual 2. I only started taking these pills since sleep troubles from glp1's.

Eat a small amount of carbs, around 20g, within an hour of going to bed. This often works to fix GLP induced insomnia.

 

[newguy2]

dont take anti histamines eto sleep theyll turn you retarded, figure out why you arnet sleeping

It is a fairly common side effect of these drugs. I don't think it is listed as one of the mains but if you look at anecdotal user experience you see it quite a bit.

Eat a small amount of carbs, around 20g, within an hour of going to bed. This often works to fix GLP induced insomnia.

Interesting, any more info on that? I think I likely do this most nights so might not be helpful. But I am always looking for more reasons to eat more apple cinnamon rice cakes.

 

[Ghoul]

It is a fairly common side effect of these drugs. I don't think it is listed as one of the mains but if you look at anecdotal user experience you see it quite a bit.

Interesting, any more info on that? I think I likely do this most nights so might not be helpful. But I am always looking for more reasons to eat more apple cinnamon rice cakes.

GLPs can cause nighttime hypoglycemia. The brain senses an unstable supply of glucose, its main energy source, freaks out, wakes you up so you'll do something about it.

The timing is important, especially since digestion is slowed down. You may find a CGM useful to confirm this is happening, and adjust the carb snack timing and amount to so you counter the glucose dip and ensure stable levels through the night.

 

[Liter O' Test]

GLPs can cause nighttime hypoglycemia. The brain senses an unstable supply of glucose, its main energy source, freaks out, wakes you up so you'll do something about it.

The timing is important, especially since digestion is slowed down. You may find a CGM useful to confirm this is happening, and adjust the carb snack timing and amount to so you counter the glucose dip and ensure stable levels through the night.

Is this related?

I wake up like 4 hours after sleep, anxious, I check my blood sugar its usually in the 90s, which is higher than it should be,
then the only way to sleep again is to eat like 160g of cream of rice or cornflakes
then i pass out into blissfull sleep thats more restful than the first 4 hours

 

[newguy2]

GLPs can cause nighttime hypoglycemia. The brain senses an unstable supply of glucose, its main energy source, freaks out, wakes you up so you'll do something about it.

The timing is important, especially since digestion is slowed down. You may find a CGM useful to confirm this is happening, and adjust the carb snack timing and amount to so you counter the glucose dip and ensure stable levels through the night.

Oh wow I wonder if it is, I usually don't notice being hypo, but I am also in bed. Usually get up to pee never dizzy or anything. I'll look into it.

Is this related?

I wake up like 4 hours after sleep, anxious, I check my blood sugar its usually in the 90s, which is higher than it should be,
then the only way to sleep again is to eat like 160g of cream of rice or cornflakes
then i pass out into blissfull sleep thats more restful than the first 4 hours

Ha that sounds like fun.

 

[Liter O' Test]

Update on my post: labs just came back. Glucose is 62 mg/dl, insulin is 2.3 uIU/ml, and A1c is 4.9. Both glucose and insulin are on the low side, but nothing dramatic. Tirz is still doing its job perfectly. If anyone here is struggling with insulin resistance, trust me, Tirz can pull you out of it the same way it did for me.

what are your macros?

 

[Ghoul]

Is this related?

I wake up like 4 hours after sleep, anxious, I check my blood sugar its usually in the 90s, which is higher than it should be,
then the only way to sleep again is to eat like 160g of cream of rice or cornflakes
then i pass out into blissfull sleep thats more restful than the first 4 hours

Waking in response to unstable glucose is accomplished by a cortisol pulse. It creates a mini "dawn effect" that raises blood sugar. Carbs blunt the cortisol surge and adrenaline release, so you relax and go back to sleep.

 

[eryximachus]

Advil PM

High probability of causing dementia

 

[Liter O' Test]

Waking in response to unstable glucose is accomplished by a cortisol pulse. It creates a mini "dawn effect" that raises blood sugar. Carbs blunt the cortisol surge and adrenaline release, so you relax and go back to sleep.

thats what i thought, but im eating 550g carbs right now and in a surplus. 250p 550c 50f. 5mg tirz. Im going to increase the gear and food and see if it resolves. might have to eat more fat before bed but i dont really want to do that

 

[The Answ3r]

what are your macros?

I’m a lightweight right now, sitting at 160 g protein, 65 g fats, and 300 g carbs, which puts me at roughly 2,445 kcal total. Honestly, hitting the carbs is the hardest part for me. Sometimes I sneak them in with fruit, but most of the time I’m saved by my trusty sidekick: oven-baked potatoes. Without those, I’d probably be stuck looking like a keto influencer.

 

[Liter O' Test]

I’m a lightweight right now, sitting at 160 g protein, 65 g fats, and 300 g carbs, which puts me at roughly 2,445 kcal total. Honestly, hitting the carbs is the hardest part for me. Sometimes I sneak them in with fruit, but most of the time I’m saved by my trusty sidekick: oven-baked potatoes. Without those, I’d probably be stuck looking like a keto influencer.

you need some ice cream before you pass out with those blood levels lol.
thanks for sharing the lab data.