GC-1 (Sobetirome) as long term TRT (Thyroid Replacement Therapy)?

Luke391

Member
Been Thyroid deficient since I was a kid. Was on T3 and T4 since 12 or 13, Doctor had me get off the thyroid meds at like 17. I don't know why. Looking back the dosages also didn't make much sense. It was a ton of T3 and barely any T4 (like 30-40mcg T3 and 4-8mcg T4). Since I got off tho I had chronically low energy, worse mood and noticed much easier bodyfat gain (I'm on tirzepatide and L-carnitine now so bodyfat is no longer an issue, but still much less energy and less motivated than when I was on it) .
I'm sure I'm still thyroid deficient but I'll get 2 bloodworks done spaced 4 weeks to confirm. If I am I was planning to get back on it. My diet is very high in Iodine and vitamin A so I see no point in supplementing those. Also I get a good amount of Selenium and supplement 25mg of zinc on the days I don't eat red meat.
I was wondering if I could use a microdose of T3 and then fill in with GC-1, because of the advantages it has over T3. It doesn't enlarge the heart at low-moderate dosages and it aggregates in skeletal muscle and liver more, increasing the calories burned by muscle tissue and decreasing cholesterol and tryglicerides. It also seems to have a muscle preserving effect.
The idea was like 5-10mcg T3 (just to keep TSH lower), 50mcg T4 and 25mcg GC-1, to maybe up to 37.5mcg.
 
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