estrogen metabolism protocol

[hardasnails1973]

You may want to have a stool sample done and if you have out of balance flora then you body is detoxifying the estrogen but due to elevated liver enyzme glucuronidase which can also be from bad bacteria. Once estrogen is metabolised it gets binded so you you can excrete it, but with elevated glucuronidase these bonds are broken and it is recirculated in the body not as estrodial but as other metabolites of estrogen doing the same damage as e2. To lower this you need calcium d glucurate 500 mgs 3-4 times a day and it should lower total estrogen not just estrodial. Given the fact of the SAD eating patterns it is estimated that bad flora out weight the good flora by a great number. As you can see how problems with immune and auto intoxification can occur easily.

what i seem to think is happening to me is estrodial is fine but shbg is high because of elevated of already metabolized estrogen not e2 but its metabolites (good and bad estrogen) which are not being carried out due to bonds being broken by bacteria glucuronidase which is causing negative feed back loop to the hypothalamus and all the signs of estrogen domaince..So if one has skewed bad:good ratio and has hidden dybiosis of the bowel then they are in a vicious cycle untill the glucordation is brought back into balance or to remove the pathogenic bactera. I have been tested positive for ecoli and this is one of the little basatards that produce the greatest of amount of the enyzme. Alleviating the pathogenic bacteria may be one answer to correcting estrogen metabolism and taking the excess of load off the liver as well as causing an extra strain on methylation (hence TMG comes in) Yes you may be breaking it down through proper estrogemn metabolism but are you getting rid of it out your body properly and not having it reciriculate ?

Estrogen procotol
1. reduce aromatase - zinc, arimdex, magnesium, b-6, increasing progesterone (pregnenolone cream), reduce alcoholic intake , lose weight
2. proper estrogen metabolism good:bad ratio - Dim, fish oils, more fruits and veggies,melatonin (proper ratio of AA:EPA essential)
3. Identify pathogens through stool sample - once identifed remove pathogens, repopulate with good bacteria (,SACCHAROMYCES BOULARDII) and re-establish with prebiotics (inulin, FOS) , repair intestinal lining with glutemine
4. If anaerobic bacteria are elevated or low in n-buteryate remove red meat, supplement 500mgs calcium d glurate with each meal 3-4 times a day to reduce the glucuronidase which removes already metabolised estrogen from the body and keeps it reciruclating in the blood streams causing extra strain on the liver. Get retested in 2 months to see if pathogens are gone, and enzyme returned to proper levels
4. Provide proper methyl support for the liver - faster estrogen is metabolised greater depletion of methy groups and hence can lead into high or low homocysteine levels aka jams up methionne synthase pathway. Milk thistle, k-RALA, Sam-e, TMG, choline vitamin E mix tocepherols, vitmain C, zinc, taurine,nac, p5p could aid in here as well
5. eat balanced fiber to sweep out extra toxins and estrogen.

 

[hardasnails1973]

Calcium D-Glucarate supports Phase II detoxification of chemicals and hormones. By supplying a slow-release form of D-glucaric acid, calcium D-glucarate is an effective agent that enhances the deactivation of toxic substances and encourages their elimination from the body. When calcium glucarate is converted to D-glucaro-1, 4-lactone, it counteracts the enzyme beta-glucuronidase which conjugation and detoxification of steroid hormones and potentially carcinogenic compounds. Beta-glucuronidase enzymes are present in all cells, particularly the liver, kidney, lung, intestinal epithelium, breast and endocrine organs. By inhibiting this enzyme, glucaric acid derivatives may exert a protective, non-antioxidant effect on the immune system.*

reason i know this is my savior is because on organic acid test it should I was high in xylene which i later found out was a xenoestrogen and is metabolised by conjugation hence why my b-5 levels have been deficient because b-5 is precursor to coenyzme A which is the beginning of the kreb cycle. So in lamens terms the estrogen bind up the conjugation and you end up depelting your b-5 resulting with coenyzme A defieincy and hence altered fatty acid, krebs cycle and reduced cellular energy resulting in low kreb cycle metabolites and sluggish mitochondrion. it has taken me almost 3 years to finally put the pieces of the puzzle together from doing laborous hours of research on all aspects of health, liver detoxication, studying the brain, endocrine system but i think I have finally reached my resolution..For many of you that have estrogen problems and still not seeking answer an organic acids test may shed some light on what lab tests may not.

 

[Andromeda]

Nails,

I have Gilberts syndrome and have been taking Calcium D-Glucarate since July 2005 when I had an alcohol induced vomitting incident that really highlighted how weak my liver had become. I probably don't need to tell you this, but to everyone out there reading this - it really is a good value supplement.

Anyway, I have read your past posts and think your'e in a similar situation to myself. ie: estrogen dominance and something akin to adrenal fatigue. I too feel that my Parasympathetic side is weak, meaning I'm very slow to recover from gym workouts, cuts/bruises etc. Weak erections etc. - All this in spite of eating a diet which should allow healthy function of the parasympathetic side.

So, please tell me how you came to find out you were loaded with xenoestrogens - what is the name of the stool test or whatever it was you had done?
Secondly, how long have you been 'recovered' and what changes are you noticing in terms of energy and sexual function?

Cheers

 

[jaydee]

Andromeda, do you find that using Calcium D Glucarate brings your billirubin back down?
I also have gilberts and I was told that it means I have copper toxicity. My first doctor though, said it was sluggish phase 2 detoxification, but no amount of CDG could bring my billirubin numbers down.

 

[hardasnails1973]

Nails,

I have Gilberts syndrome and have been taking Calcium D-Glucarate since July 2005 when I had an alcohol induced vomitting incident that really highlighted how weak my liver had become. I probably don't need to tell you this, but to everyone out there reading this - it really is a good value supplement.

Anyway, I have read your past posts and think your'e in a similar situation to myself. ie: estrogen dominance and something akin to adrenal fatigue. I too feel that my Parasympathetic side is weak, meaning I'm very slow to recover from gym workouts, cuts/bruises etc. Weak erections etc. - All this in spite of eating a diet which should allow healthy function of the parasympathetic side.

So, please tell me how you came to find out you were loaded with xenoestrogens - what is the name of the stool test or whatever it was you had done?
Secondly, how long have you been 'recovered' and what changes are you noticing in terms of energy and sexual function?

Cheers

Stool sample was great smokies CSDA 2.0
organic acid tests- was from great plains

How did I come to this conclusion my homocysteine level was 3.9 which is way too low and something was depelting my cholne, b-5, and methyl group which estrogen will do. Since being sick my testosterone/estrogen ratio was less then 15:1 the whole time and my low copper levels in the blood was reflected of copper toxcitiy (meaning body was not excerting copper but holding on to it due to adrenal fatigue which was caused by estrogen imbalnaces resulting from hypothyroid (from several factors) ). The cause of this mess was several factor from drinking 10 cups of green tea a day, to excessive caffine, to under eating. The main cause of the problem seriously was low melatonin: high cortisol imbalace because of study late night on the computer till 1-2 pm and getting up then going to work an it being the winter time I was not exposed to sunlight because of the dark winter nights and this will automatically reduce your t-3 levels by 30-40% and cortisol from hard workouts /work and then the infection from bad food just put me over the edge and was never treated properly and bascially sealed my fate almost killed me. If I was not as big as I was I would have been dead. After throughly investigating the liver becuase when I went to the chinese dr she diagnosed me with liver stagnation but i had no clue of what that was so i started researching and after 3 years I finally have majority of liver pathways learned but I am learning alot more now since I have the idea and concepts down. Xylene if you resarch it is a xenoestrogen which comes from petroluem, gas exhaust fumes and can also be produced endogeniouslt from your own bacteria, and glycine is suppose to conjugate this well I took glycine for a year religiously and still nada then I wanted to know more taurine can also help conjugate as well and if you have a zinc defiecincy you tend to excrete more taurine causing a defiency. Also my WBC vitamin analyisis and also my organic acids test should I was pissing out b-5 and it was low in my blood levels and I could not understand why. I was taking 2000 mgs of b-5 and it was still low? Thats because estrogen was depelting the shit out of it because it is also needed for conjugation detoxfication priorary for manufatuaring of Coenyzme A which drive mitochiondrion. With out coenzyme a cellular energy comes to a screeching hault. Acetic groups can be added with apple cider vingear and alsco acetyl supplements NAC ALCAR, ect. Citrate can be fueled with magneisum citrate or other minerals binded with citrate to drive the kreb cycle. AS I stated befiore there are more compenents of estreogen metabolism which need to be explored

all these areas need to be explored
1. testosterone , dhea, progesterone to estrodial or esterone
2. estrodial/ esterone to estrogen metaboliites
3. estrogen metabolites escorted out the body properly and effiency and no recirculation back through the liver

 

[hardasnails1973]

Andromeda, do you find that using Calcium D Glucarate brings your billirubin back down?
I also have gilberts and I was told that it means I have copper toxicity. My first doctor though, said it was sluggish phase 2 detoxification, but no amount of CDG could bring my billirubin numbers down.

sunlight and Sam-3, vitamin C, nac brings bilirubin down

 

[hardasnails1973]

men, the failure to metabolize estrogen has been linked to reverse effects, including that of promoting increased internal blood clotting associated with both heart attacks and strokes. This was shown in many studies, including the long-term Framingham Heart study. In that study, men with the highest estradiol or unmetabolized estrogen levels showed the greatest risk of early heart attack.

http://www.canarys-eye-view.org/metabolic_basis/hormones/estrogens.html

http://edrv.endojournals.org/cgi/content/full/19/5/593#SEC2

http://www.canarys-eye-view.org/supplements/caldg.html

http://www.canarys-eye-view.org/challenges/endocrine-dis.html

 

[hardasnails1973]

My solution and fpr many others are very simple

1. life style changes and modifications, stress reduction,
2. identify the pathogens and remove them
3. examine estrogen metabolism and correct as shown above
4. support other liver pathways - liver detoxification panel
5. support adrenals./thyroid and posssible testosterone if needed over time one may be able to able to taper off these
6. restabilize cell membrane stability
7. replenish proper electrolyte imbalnaces
8. Be happy .

 

[chip douglas]

Nails,

I have Gilberts syndrome and have been taking Calcium D-Glucarate since July 2005 when I had an alcohol induced vomitting incident that really highlighted how weak my liver had become. I probably don't need to tell you this, but to everyone out there reading this - it really is a good value supplement.

Anyway, I have read your past posts and think your'e in a similar situation to myself. ie: estrogen dominance and something akin to adrenal fatigue. I too feel that my Parasympathetic side is weak, meaning I'm very slow to recover from gym workouts, cuts/bruises etc. Weak erections etc. - All this in spite of eating a diet which should allow healthy function of the parasympathetic side.

So, please tell me how you came to find out you were loaded with xenoestrogens - what is the name of the stool test or whatever it was you had done?
Secondly, how long have you been 'recovered' and what changes are you noticing in terms of energy and sexual function?

Cheers

This is quite a relevant thread cause I too have consistently elevated Bilirubin (PCP thinks it's Gilberts's syndrome) and now my E2 is too high at 35 pg/ml, libido is non-existent, erections weak.

 

[zkt]

You guys have a clinical diagnosis of Gilbert`s Syndrome ? Have I got that right ?

 

[hardasnails1973]

You guys have a clinical diagnosis of Gilbert`s Syndrome ? Have I got that right ?

Basically your bile acids are probably being sequestered and reabsorbed bck into the liver causing fat metabolism and detoxifcation problems. mainly its due to lack of bile production.

Sam-e is used for this disease.

 

[Naturdoc]

HArdasnails. Amen on your take concerning estrogen metabolism. Good protocol.

 

[Andromeda]

Andromeda, do you find that using Calcium D Glucarate brings your billirubin back down?
I also have gilberts and I was told that it means I have copper toxicity. My first doctor though, said it was sluggish phase 2 detoxification, but no amount of CDG could bring my billirubin numbers down.

Yes, I have blood tests of liver enzymes that show most of the key markers significantly lower since taking the Calcium D-Glucarate. The Dr that suggested I use it in the first place also explained that I had poor phase 2 liver function, and tend to be undermethylated with high homocysteine etc.

If it did'nt bring yours down I'm suspicious as to the cause of your elevated bilirubin, whether you took a high enough dosage, and whether the brand was any good. I use Life Extension Foundations CDG, and its only 200mg per pill, which they say you only need 1 of a day. This is BS of course - you want at least 800mg a day - so 4 tablets throughout the day

Cheers

 

[Andromeda]

Stool sample was great smokies CSDA 2.0
organic acid tests- was from great plains

How did I come to this conclusion my homocysteine level was 3.9 which is way too low and something was depelting my cholne, b-5, and methyl group which estrogen will do. Since being sick my testosterone/estrogen ratio was less then 15:1 the whole time and my low copper levels in the blood was reflected of copper toxcitiy (meaning body was not excerting copper but holding on to it due to adrenal fatigue which was caused by estrogen imbalnaces resulting from hypothyroid (from several factors) ). The cause of this mess was several factor from drinking 10 cups of green tea a day, to excessive caffine, to under eating. The main cause of the problem seriously was low melatonin: high cortisol imbalace because of study late night on the computer till 1-2 pm and getting up then going to work an it being the winter time I was not exposed to sunlight because of the dark winter nights and this will automatically reduce your t-3 levels by 30-40% and cortisol from hard workouts /work and then the infection from bad food just put me over the edge and was never treated properly and bascially sealed my fate almost killed me. If I was not as big as I was I would have been dead. After throughly investigating the liver becuase when I went to the chinese dr she diagnosed me with liver stagnation but i had no clue of what that was so i started researching and after 3 years I finally have majority of liver pathways learned but I am learning alot more now since I have the idea and concepts down. Xylene if you resarch it is a xenoestrogen which comes from petroluem, gas exhaust fumes and can also be produced endogeniouslt from your own bacteria, and glycine is suppose to conjugate this well I took glycine for a year religiously and still nada then I wanted to know more taurine can also help conjugate as well and if you have a zinc defiecincy you tend to excrete more taurine causing a defiency. Also my WBC vitamin analyisis and also my organic acids test should I was pissing out b-5 and it was low in my blood levels and I could not understand why. I was taking 2000 mgs of b-5 and it was still low? Thats because estrogen was depelting the shit out of it because it is also needed for conjugation detoxfication priorary for manufatuaring of Coenyzme A which drive mitochiondrion. With out coenzyme a cellular energy comes to a screeching hault. Acetic groups can be added with apple cider vingear and alsco acetyl supplements NAC ALCAR, ect. Citrate can be fueled with magneisum citrate or other minerals binded with citrate to drive the kreb cycle. AS I stated befiore there are more compenents of estreogen metabolism which need to be explored

all these areas need to be explored
1. testosterone , dhea, progesterone to estrodial or esterone
2. estrodial/ esterone to estrogen metaboliites
3. estrogen metabolites escorted out the body properly and effiency and no recirculation back through the liver

Thx for that - I'm in Australia so Smokies Labs is probably not an option, however I have already seen a referral form to a local company that does CDSA 2 and other stool testing. Is it through these stool samples that you learnt about mineral toxicities/imbalances in your body like the excess copper?

 

[hardasnails1973]

Thx for that - I'm in Australia so Smokies Labs is probably not an option, however I have already seen a referral form to a local company that does CDSA 2 and other stool testing. Is it through these stool samples that you learnt about mineral toxicities/imbalances in your body like the excess copper?

Normal blood work low copper serum and ceruoplasm none responsive to copper supplementation. low uric acid serum As well as excessive estrogen to testosterone ratio driving down progesterone serums. Vrified by hair analylsis with hidden copper toxcity.

Great plains labs has a place in austrailia or metametrix labs does..

next feature is my hypothesis is iodine deficency which is altering estrogen metabolism as well. They give iodine for breast cancer and even put it in remission by it curing fibriosis on the tissue. Going to have the iodine load and spot test which is FDA approved test to test body supply of iodine. I know the patch is not accurate but it only stays for 4-6 hours at a time and my past habits indicate severe dietary imbalnces and iodine binders. iodine does seem to play a part of t4 to t3 conversion which i found interesting in a study with elevate rt3/t3 ratio.. i have not used table salt for 30 years and when dieting down was sucking down gree tea pills plus 10 cups of green tea a day and brushing teeith 3-4 times a day can one say excessive fluoride . Fluoruide cases t-4 to t3 conversion problems as well.

 

[plymouth city]

Where do you get your Calcium D Glucarate and were do you get your TMG?

 

[hardasnails1973]

Where do you get your Calcium D Glucarate and were do you get your TMG?

Biotics resarch has calcum d glucurate and even though many thinks its hookey pokey I goto a applied kinseiologist and actually she has been dead on track the whole time. I tested at 5 calciium d glucurate and she also tested me at high dosages of b-5. See what i do is let her do her thing and then compare it with results of clinical testing and shes 90% right. She told me I needed more fish oils vs les gla which 6 months ago she told me differently and this was based on RBC fatty acid test. and actually with my internal gut instinct I knew i over shot the AA/epa ratio. She also tested me needed alot of methycobalmin. Last blood test should elevated folic acid levels which means that it is not being converted due to the impairment of methione synthase which still could be from mercury build up from many years of eating tunafish. So I was given b-12 methy shots but they give you the shit and never retest you. This has been the problem from the start put you on protocol and never do follow up testing and let you hang. Well the kinesiologist just kind of reconfimred things not knowing what my new lab blood results where..

 

[plymouth city]

Biotics only sells to healthcare professionals

 

[hardasnails1973]

Biotics only sells to healthcare professionals

true but, some health food store has them in the back or behind the shelf, thats how i get mine

 

[Iggy_347]

Great thread......
I have used the product "Post Cycle" from Protein Factory which contains Calcium D-Glucarate to lower my High E levels and I have had good results. I have also used DIM but If I am not careful about the dosage have found that I can drive my E2 too low with DIM. When taking Calcium D-Glucarate I have not gotten too low.

Just my 2 cents