Community Review: IndiaMart Ancillaries

Lol they immediately id'd you as the Meso crowd.
Why not get a different iron?
I think Abbott or some other big pharma brand produces them too.
View attachment 381599

I stick with it only because I’ve already had dextran as multiple infusions and know I do well with it.

The ferric carboxy has the highest risk of hypophosphataemia than other forms, and it’s harder to treat than traditional. I’m in an iron group, and I know that skews perception, but there are so many stories of people suffering longterm. I’ve read that a lot of medical sites have moved away from it as first choice because of the risk, and that they have multiple injury lawsuits.

I remember you were doing the pig iron. Are you using these others IM or IV? I don’t have IV experience, so that limits my choices, too. Maybe I’ll try it, can’t be that hard and I have good veins.
Sharvik and De mega are the same. Use shared bank accounts etc
What ninja skills did you use to figure this out? Sharvik responded faster than De Mega. I wonder if they’re handled by different sales teams.
 
The ferric carboxy has the highest risk of hypophosphataemia than other forms, and it’s harder to treat than traditional. I’m in an iron group, and I know that skews perception, but there are so many stories of people suffering longterm. I’ve read that a lot of medical sites have moved away from it as first choice because of the risk, and that they have multiple injury lawsuits.

which has the lowest risk of anything? :cool:

I remember you were doing the pig iron. Are you using these others IM or IV? I don’t have IV experience, so that limits my choices, too. Maybe I’ll try it, can’t be that hard and I have good veins.

i use Gleptoferron, it's not even approved in humans lol. it is designed to stain less in pigs vs iron dextran because nobody wants to buy bloodied meat. i pin it IM 1.5in DG. I was considering to get the newer ones (should be better right?) but was wondering why people were sticking to dextran.

What ninja skills did you use to figure this out? Sharvik responded faster than De Mega. I wonder if they’re handled by different sales teams.

he has all of them on speed dial at this point
should probably organize a groupbuy using his name
 
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I stick with it only because I’ve already had dextran as multiple infusions and know I do well with it.

The ferric carboxy has the highest risk of hypophosphataemia than other forms, and it’s harder to treat than traditional. I’m in an iron group, and I know that skews perception, but there are so many stories of people suffering longterm. I’ve read that a lot of medical sites have moved away from it as first choice because of the risk, and that they have multiple injury lawsuits.

I remember you were doing the pig iron. Are you using these others IM or IV? I don’t have IV experience, so that limits my choices, too. Maybe I’ll try it, can’t be that hard and I have good veins.

What ninja skills did you use to figure this out? Sharvik responded faster than De Mega. I wonder if they’re handled by different sales teams.
Maybe hire a rouge nurse? You probably need a drip bag and sterile water for dilution. Have any nurse friends? Here in Australia the GP sends you to hospital for low iron and they do it. There can be complications like nausea and skin colouration. I'm getting shudders as I have flashbacks remembering someone close to me go through it post partum.

@GreatOak did the original detective work. I had it confirmed when De Mega gave me Sharvik's WhatsApp number and bank account as his own.

Post in thread 'Community Review: IndiaMart Ancillaries'
 
Finerenone
Stops hormonal fibrosis signaling inside kidney tissue prevents long-term scarring after AKI or preventative.

Eplerenone
Reduces aldosterone-driven pressure load lowers mechanical stress on filters

Empagliflozin / Dapagliflozin
Lowers pressure inside the glomerulus itself
stops hyperfiltration wear/tear
1771902462544.webp

Eplerenone and Finerenone are both of the same class - MRA. The difference is that Fin is more selective, has lower risk of elevated K, lowers BP less and has stronger anti fibrotic activity. EP has only been evaluated for HF whereas Fin is evaluated for HF and CKD w T2D. As such, studies on the impact of EP on CKD is scarce.

Dapagliflozin is a SGLT2 and well, these are known to slow down progression of CKD. There are studies that show that EP is better for CKD, but with the added risk of higher K.

1771902727693.webp

But then you also have studies that show it's indifferent from RAS (ARB/CCB).
1771902909393.webp

Since it's not evaluated for treatment of CKD, we will never know.
Personally I see an increase in K or a decrease in BP as unwanted sides -- what we want is something kidney focused.

Allopurinol / Febuxostat
Protects renal blood vessels from uric-acid-driven damage preserves afferent arteriole integrity

This seems to be more gout related. My uric acid is low, i believe it might be due to reta so I'm not entirely sure about uric acid related stuff.

Pentoxifylline
Lowers inflammatory cytokines in renal tissue reduces ongoing micro-inflammation

I take this, but i don't think it helps kidneys at all. I didn't see any noticiable benefits to kidney markers. I take it as it's the only medication that improves RBC deformability.

I believe the best benefit is probably from SGLT2 + Fin.

And for those who want more natural options, you have
Astragaloside IV (poor oral bioavability tho - i'm working on an injectable)
Astragalus 70% extract
Urolithin A
 
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View attachment 381673

Eplerenone and Finerenone are both of the same class - MRA. The difference is that Fin is more selective, has lower risk of elevated K, lowers BP less and has stronger anti fibrotic activity. EP has only been evaluated for HF whereas Fin is evaluated for HF and CKD w T2D. As such, studies on the impact of EP on CKD is scarce.

Dapagliflozin is a SGLT2 and well, these are known to slow down progression of CKD. There are studies that show that EP is better for CKD, but with the added risk of higher K.

View attachment 381674

But then you also have studies that show it's indifferent from RAS (ARB/CCB).
View attachment 381675

Since it's not evaluated for treatment of CKD, we will never know.
Personally I see an increase in K or a decrease in BP as unwanted sides -- what we want is something kidney focused.



This seems to be more gout related. My uric acid is low, i believe it might be due to reta so I'm not entirely sure about uric acid related stuff.



I take this, but i don't think it helps kidneys at all. I didn't see any noticiable benefits to kidney markers. I take it as it's the only medication that improves RBC deformability.

I believe the best benefit is probably SGLT2 + Fin.

And for those who want more natural options, you have
Astragaloside IV (poor oral bioavability tho - i'm working on an injectable)
Astragalus 70% extract
Urolithin A
Thanks man, it's like a love hate relationship with you. Haha You send me down rabbit holes for nights on end. But seriously I appreciate it always.

I've found it on India Mart I'll ask for some quotes. Bayer Zydus 10/20mg, Sun Pharma 20mg.

Edit: when you get a chance DM @Cman90 he's got a question you can answer in more detail.
 
which has the lowest risk of anything? :cool:
If I didn’t have autoimmune stuff I’d be less risk averse. I wonder if that’s why so many women have higher rate of incidence since we tend to have more autoimmune disorders.
i use Gleptoferron, it's not even approved in humans lol. it is designed to stain less in pigs vs iron dextran because nobody wants to buy bloodied meat. i pin it IM 1.5in DG. I was considering to get the newer ones (should be better right?) but was wondering why people were sticking to dextran.
I assume because it’s cheaper maybe? The newer ones are def more convenient, and can be given at higher doses nor require as many injx. The other one you showed and sucrose are popular in the iron group. Depending on how IM dextran goes, I might switch if the increase isn’t significant enough.
Maybe hire a rouge nurse? You probably need a drip bag and sterile water for dilution. Have any nurse friends? Here in Australia the GP sends you to hospital for low iron and they do it. There can be complications like nausea and skin colouration. I'm getting shudders as I have flashbacks remembering someone close to me go through it post partum.
After my comment, I searched the internet and saw multiple stories of nurses being given no instruction and just being told to figure it out. o_O Seems about right for American healthcare. I’ve had multiple infusions without issue, and mine wasn’t get diluted. It’s strange watching sludge go in. I forgot I have an aunt who would probably be willing to help, good idea.
 

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