Cinnatropin HGH, and high dimer %. Should I worry?

[Ingemar]

Hi.
I just got myself 10 pens of Cinnatropin (30iu). I know its Pharma Grade, but I found an other post on the forum here where it was presented a
lab test from Janoshik on these pens, and it showed around 95% purity and almost 2% dimmer and other proteins.
The purity is no concern, I can just add more to compensate for that. Whats have me concerned is the dimer result. I read that dimer

"Dimer is when two molecules of HGH join together, which makes them unable to bind to receptors properly decreasing the effectiveness and high dimer is also associated with more side effects. "
But what does this really mean in pratice? Is it dangerous or just not as efficient? What are the concerns?
Could it be that the testing from Janoshik on these Cinnatropin pens was just a bad batch? Can you go from 0% dimer to for an example 2% if its not stored properly?

Thanks

 

[Ingemar]

bump

 

[UncleBuns]

There are no analyses of rhGH side effect severity by preparation that have been subjected to rigorous statistical methods. @janoshik believes, based on impressions from his (private, secure, and unpublished) data that dimer content is particularly associated with side effects. I believe this to be true (both anecdotally by personal experience & by understanding what dimer content reflects).

Dimerization occurs when two molecules of GH join together (aggregation) through usually noncovalent forces - usually during manufacture (lyophilization, etc.). Such GH cannot bind tightly or with great torsional force at the GHR, thus it has reduced potency while being associated with more side effects (e.g., lethargy). In pharmaceutical preparations that comply with USP Pharmacopeia standards, <= 4% dimer content, i.e., Limit of high molecular weight proteins), is the upper threshold.

Clearly, dimer content alone is insufficient to explain the widespread anecdotes of different responses to different (but high purity and low dimer content) rhGH preparations. It is my opinion that these self-reports stem largely from attribution errors and human failures to accurately determine cause-effect (e.g., rooting out nutritional influences [e.g., electrolyte, water], the dose * time effects [e.g., decrements in GH response as a decrease in serum IGF-I modulated largely by IGF-I bioavailability and IGFBP dynamics], etc.)

Something I found from a quick search of "dimer + effect". I'm not very knowledgeable about dimer except that it's undesirable. Hit up that search bar with different word combos and you'll likely find what you need.

 

[Ingemar]

Something I found from a quick search of "dimer + effect". I'm not very knowledgeable about dimer except that it's undesirable. Hit up that search bar with different word combos and you'll likely find what you need.

Thanks allot

 

[Csshotty]

There might be a correlation between dimer and side effect ratio but no direct causation. There are tons of Chinese HGH without dimer, apparently, that still show a ton of sides.

In the Cinnatropin pilot study it was demonstrated that it was superior vs Norditropin in regards to IGF-1 (274 vs 246) but e.g. BP and HR were also higher on Cinnatropin. But it was only a small trial with 30 patients.

 

[thomasdurden]

I want to use Cinnatropin but I can find many more generics for this money, is it worth it for this price difference?

 

[MyNameIsJeff]

Cinnatropin is low-quality overpriced garbage. If you buy and use it then you are a retard.

Post in thread 'International HGH price comparison'

Nov 25, 2024

• MyNameIsJeff

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[thomasdurden]

Cinnatropin is low-quality overpriced garbage. If you buy and use it then you are a retard.

Post in thread 'International HGH price comparison'

Nov 25, 2024

• MyNameIsJeff

• 
• 

You say that anyone who uses and advocates cinnatropin is an idiot right?

 

[Ghoul]

No it isn't. And in general, you don't want any pharma reconstituted GH outside of official channels, not shipped using a cold chain.

 

[thomasdurden]

Post in thread 'International HGH price comparison'

Nov 25, 2024

• MyNameIsJeff

• 
• 

Thank you very much for this, I will look for it right away

 

[MyNameIsJeff]

You say that anyone who uses and advocates cinnatropin is an idiot right?

more than that, a venerable RETARD