Different effects from different GH brands

[Andrew Androgen]

I've used Norditropin in the past and it made me feel very sleepy. This was no problem as I took it before bed and had awesome sleep quality.
Now I've been using Genotropin for just over a week at the same dose and have not noticed this effect at all.
I'm pretty sure my geno is legit as I bought it off one of the good trusted vendors here. The only effect I've noticed is an increase in body weight of about 3lb on just 2iu per day eating exactly the same number of calories as before.

 

[HB_22]

Well I noticed this too. I used Pfizer Genotropin a couple years ago and had very numb hands at 4IU ed. I am now on Optitropin 4IU and dont have the slightest numbness, but my sleep is awesome (it was okay with Pfizer genos).

I just think everyone has to try different brands and just stick to the HGH that works best for him.

 

[VaDImadi]

Well I noticed this too. I used Pfizer Genotropin a couple years ago and had very numb hands at 4IU ed. I am now on Optitropin 4IU and dont have the slightest numbness, but my sleep is awesome (it was okay with Pfizer genos).

I just think everyone has to try different brands and just stick to the HGH that works best for him.

But that's like saying, everyone needs to try different brands of testE and stick with the one that works best for them

Hgh, like testE is a set product, the effects should be standard across all brands.

The next conclusion is you're using sub par stuff. Which the HGH game is absolutely riddled with, unfortunately.

Far too hit and miss, taking a chance every time you order, which is unfortunate for the price you pay

 

[HB_22]

There is something about hgh that I haven't figured out yet but even different pharma brands give me different sides. Not sure why, maybe its the purity or whatever.

 

[1tank1]

Best GH I ever used was Ansomone. That shit was fucking awesome at 4iu-8iu...

I used Jintropin at same doses and suffered very bad side effects.

 

[M@NU]

Best GH I ever used was Ansomone. That shit was fucking awesome at 4iu-8iu...

I used Jintropin at same doses and suffered very bad side effects.

the 200iu kits of jins are the best pharma hgh for me, hands down together with humatrope.

 

[lilhawk]

There is something about hgh that I haven't figured out yet but even different pharma brands give me different sides. Not sure why, maybe its the purity or whatever.

Could be due to different fillers and how your body reacts to them.

 

[1tank1]

jins are the best pharma hgh for me

Strong stuff even at low doses (if legit).
I think GH purity was on a different level back then....assuming we're both talking about Gensci?

Kits were 100iu not 200iu in my circle....

 

[M@NU]

Strong stuff even at low doses (if legit).
I think GH purity was on a different level back then....assuming we're both talking about Gensci?

Kits were 100iu not 200iu in my circle....

yes, gensci europharm

 

[HB_22]

Best GH I ever used was Ansomone. That shit was fucking awesome at 4iu-8iu...

Yeah I had Ansomone in 2017. A few IUs per day and I went straight to sleep, I couldn't handle the lethargy. That shit was strong.

 

[Country Club Hero]

Idk what they are called. Excipients maybe? But Ive read those pharma ones have a few extra ingredients for different purposes. One example is whatever it is they add to Genos to make them smell like a pediatrician’s office. Maybe it’s different little additions similar to that affecting us differently. Because I agree that GH should be GH across the board, otherwise.

 

[lilhawk]

Idk what they are called. Excipients maybe? But Ive read those pharma ones have a few extra ingredients for different purposes. One example is whatever it is they add to Genos to make them smell like a pediatrician’s office. Maybe it’s different little additions similar to that affecting us differently. Because I agree that GH should be GH across the board, otherwise.

That smell is the same for all GH pens. It’s the preservative added to prevent degradation, insulin pens smell the same as well. GH is GH when it comes to pharma, only difference between brands are the different fillers for the most part.

 

[Liska]

Idk what they are called. Excipients maybe? But Ive read those pharma ones have a few extra ingredients for different purposes. One example is whatever it is they add to Genos to make them smell like a pediatrician’s office. Maybe it’s different little additions similar to that affecting us differently. Because I agree that GH should be GH across the board, otherwise.

This has been discussed, the fillers and amounts for various pharma HGH can be checked online at rxlist or the leaflet for each product, with almost all brands using mannitol based filler (and so does generic HGH) whereas Jintropin & Serostim use sucrose but ultimately the amounts of any fillers used are not sufficient to cause any side effects (they're also used in most peptides except HCG).

Unfortunately the rather frustrating truth is that we don't know yet what causes these different responses to HGH, as they don't seem consistent across users of the same product either.

It shouldn't be necessary at this point but I'll politely ask everyone to ignore tank's posts in this thread completely as he'll be posting fucked up misinformation as usual.

 

[Andrew Androgen]

Has anyone reading this noticed an increase tendon or ligament pain from GH?
My tendons as well as the inside of my knee (ligament) have been hurting more since I've been using genotropin at just a replacement dose of 2iu/day.
I wonder if the GH is responsible?
I thought low dose GH was supposed to be beneficial for tendons and ligaments?

 

[HB_22]

Actually every knee pain or whatever I had went either completely away or at least improved a lot.

 

[1tank1]

Actually every knee pain or whatever I had went either completely away or at least improved a lot.

I agree with this. The only times I got any pain with GH were when I pushed the dose too high and got sensations in the bones/joints/extremities (carpal syndrome, numb feet/toes etc).

Maybe that could be mistaken for pain in the ligaments/tendons or possibly higher doses could also cause pain in those areas too.

Everyone reacts differently to drugs and we can all get different side effects.

 

[ConfusedAF]

From what I read, different effects might be caused by HGH dimer or other impurities, so they could be the same dose yet feel different.

 

[Type-IIx]

Has anyone reading this noticed an increase tendon or ligament pain from GH?
My tendons as well as the inside of my knee (ligament) have been hurting more since I've been using genotropin at just a replacement dose of 2iu/day.
I wonder if the GH is responsible?
I thought low dose GH was supposed to be beneficial for tendons and ligaments?

Supraphysiological GH levels is associated (see acromegaly) with osteoarthritis incidence and severity, arthalgia (bone pain), soft-tissue swelling leading to nerve entrapment, etc.

At 2 IU daily you may be d3d3-GHR homozygous (genotype influencing sensitivity to rhGH; many report rapid onset of negative side effects), or perhaps your estradiol levels are very high (causing increased IGFBP-1 & thereby reducing free IGF-I availability and endogenously unleashing GH secretion by feedback withdrawal, tending to increase side effects at the expense of reduced benefits of rhGH).

RhGH is associated with increased collagen type I & III activity (reflecting changes in tendon, ligaments & bone), but this is not necessarily conducive to benefits per se. It can be detrimental, and lead to pathology (see acromegaly, again).

 

[Type-IIx]

There are no analyses of rhGH side effect severity by preparation that have been subjected to rigorous statistical methods. @janoshik believes, based on impressions from his (private, secure, and unpublished) data that dimer content is particularly associated with side effects. I believe this to be true (both anecdotally by personal experience & by understanding what dimer content reflects).

Dimerization occurs when two molecules of GH join together (aggregation) through usually noncovalent forces - usually during manufacture (lyophilization, etc.). Such GH cannot bind tightly or with great torsional force at the GHR, thus it has reduced potency while being associated with more side effects (e.g., lethargy). In pharmaceutical preparations that comply with USP Pharmacopeia standards, <= 4% dimer content, i.e., Limit of high molecular weight proteins), is the upper threshold.

Clearly, dimer content alone is insufficient to explain the widespread anecdotes of different responses to different (but high purity and low dimer content) rhGH preparations. It is my opinion that these self-reports stem largely from attribution errors and human failures to accurately determine cause-effect (e.g., rooting out nutritional influences [e.g., electrolyte, water], the dose * time effects [e.g., decrements in GH response as a decrease in serum IGF-I modulated largely by IGF-I bioavailability and IGFBP dynamics], etc.)

 

[Andrew Androgen]

Has anyone reading this noticed an increase tendon or ligament pain from GH?
My tendons as well as the inside of my knee (ligament) have been hurting more since I've been using genotropin at just a replacement dose of 2iu/day.
I wonder if the GH is responsible?
I thought low dose GH was supposed to b beneficial for tendons and ligaments?

Actually every knee pain or whatever I had went either completely away or at least improved a lot.

What dose of Genotropin did you feel best?