I have a completely made up thought on this after looking at a lot of the heavy users.
I noticed a lot of the guys that use the liver toxic stuff, SD.. methyltren.. that kind of real dirty stuff, look a lot rougher than some of the other guys. I wonder if crushing the ability of the liver to function properly does some damage to skin repair.
Also just for myself, I was low t for most of my puberty and young adult years and it gave me a very soft, more feminine look to my face. After a few years of TRT and then some medium dosed cycles plus GH, my face/jaw widened quite a bit and I have a lot more angularity to my face. Most people say I look significantly better now. But I also had a hair transplant, get botox regularly, and have a pretty thorough skin care routine for a straight guy lol. So I think for some people, if you're using mostly bio identical compounds and a small amount of other stuff, its not going to age you as fast.
But i made all this up and have no science whatsoever to back any of this up