Steroid Profile Anadrol

[oldgrey]

interesting! Do you think that taking it sub

I am really curious for your results if you decide to try 50-100mg.

Also, I opted to start with Adrol instead of Sdrol simply due to the supposed toxicity being less with Adrol. But, to my understanding, that’s still debated from everything I’ve read on it.

I was curious at one point to take YK-11 while I was taking Rad & osta, but there was so many anecdotal claims of it causing such an increase in tendinitis among other things that I decided against it.

Kinda reporting back with some interesting and new findings, ended up using adrol for a bit earlier than expected for a month.
A bit of Mast really seems to help keep the bloat / water retention / edema i had prior (of course there are many lifestyle factors but it was very pronounced last time). I do not at all feel like a moon face water buffalo vs before when i used.

I personally think I bet a better "strength" boost taking it orally vs sublingually, where as I find anavar VERY effective sublingual, anadrol doesnt hit me the same. This could be the specific adrol pills I have, but i have used at least 4 brands of anavar sublingual with same technique and all effect me the same so I am not sure.. perhaps the liver conversion is truly important for adrol. Also of course this also means taking it minimum 1+ hours pre workout vs like 30 min (probably 2 is better)

I also feel that the adrol also needed more consistent daily use for the effects. Anavar i feel I can use like an energy drink at any point on any day for a "kick", i feel the adrol only really started to shine after regular almost daily use as if it needed to build up in my system.

I also only used it at 50mg this time, I don't think anything less is for me, and I ABSOLUTELY will be trying MORE when I use it again this winter LOL.

Overall, I liked it this experience. Some days I was like "DAMN im strong", some days were "hmm not getting much today". Weirdly like I said, I feel it needed to "build up" almost like an injectable.
My bloodwork DID take a hit, not scary, but its definitely not meant for LONG term use. I would say 4 weeks, totally fine, 6-8, maybe..
First time I used it, I wasn't impressed. This time, I liked it and can't wait to try 75-100mg.

 

[ChemBB]

I personally think I bet a better "strength" boost taking it orally vs sublingually, where as I find anavar VERY effective sublingual, anadrol doesnt hit me the same.

Sounds like you had a solid run with the Adrol this time around, esp. with the Mast helping the water retention.

But on the sublingual vs. oral thing for Anadrol + Var, I gotta push back a bit based on what the actual PK data shows.

I think the differences you're feeling (better strength oral vs. sublingual for Adrol/Var hitting harder sublingually) are likely placebo. The tl;dr:

- These are already optimized for oral use: Both Adrol/Var are 17a-alkylated, so they survive liver's first-pass metabolism. Anavar has ~97% oral bioavailability, so bypassing the gut/liver via sublingual isn't adding much.

(If anything, it could lead to lower overall exposure in some cases.)

- Studies show similar or worse absorption sublingually: For Anavar, a 2020 study [0] on buccal (basically sublingual-ish) in MCT oil found bioavailability of ~62% compared to oral tablets, w/ lower peak levels (44 ng/mL buccal vs. 67 ng/mL oral). Time to peak was the same (~1 hour)

For Adrol, there's no direct data on sublingual, but we can likely assume the same behavior as Var.

- Placebo is huge: BB'ing is full of subjective feels like "damn I'm strong today". There's even a paper that shows placebo effects can mimic AAS gains. (One study had lifters who thought they were on steroids report better performance and even muscle increases.) [1]

If you're expecting sublingual Var to hit like an energy drink, that expectation ALONE could amp you up, even if the blood levels aren't different.

Curious if you've tested liver enzymes or strength metrics objectively?
Anyway, glad it worked out better this round, stay safe with the higher doses!



- [0]: Stability of Oxandrolone in Medium-Chain Triglyceride Oil and Pharmacokinetics Following Buccal Administration of the Extemporaneous Formulation in Neonates and Adults - PMC
- [1]: https://www.researchgate.net/public...rength_Training_Do_Steroids_Make_a_Difference

 

[Eddie.]

Vigorous Steve has said in a video that most orals are fine sublingual but with anadrol you're missing a metabolite (mestanolone) so you get less of its effects.

Skip to 13:46


View: https://youtu.be/c-2FFoMYWwk

 

[RockyP]

Unfortunately I’ve found that the more toxic these are on the liver (at least on paper - some guys tolerate them well) the more effective they are. No free lunches. Thank goodness for glutathione.

 

[ChemBB]

Vigorous Steve has said in a video that most orals are fine sublingual but with anadrol you're missing a metabolite (mestanolone) so you get less of its effects.

Skip to 13:46


View: https://youtu.be/c-2FFoMYWwk

I'm going to blow a gasket.

I genuinely am going to create a YT channel and reveal my face if I have to, to combat the degree of sheer idiocy and harmful information clowns like these are spreading.

The idea that taking anadrol sublingually prevents conversion to mestanolone is completely wrong on multiple levels! Let's break down why this makes zero sense (both pharmacologically, and practically):

TL;DR

• Anadrol doesn't absorb sublingually (solubility problem + saliva washout)
• 99% ends up in your stomach anyway
• Even if absorbed sublingually, metabolism still occurs systemically
• You cannot prevent mestanolone formation by changing absorption route
• 17a-alkylation already provides oral bioavailability
• This is bro-science theater with zero pharmacological basis

Problem #1: The Drug Never Actually Absorbs Sublingually

Before we even get to the metabolism question, let's address the elephant in the room: Anadrol doesn't absorb under your tongue in any meaningful amount.

The solubility issue:

• Anadrol's water solubility is 0.00521 mg/mL [0]
• Your saliva is 99% water
• 50mg would need to dissolve in over 10L of water to fully saturate
• Your mouth produces maybe 2-5mL of saliva during the time you're holding it under your tongue

What actually happens:

• The tablet/raws sit under your tongue as mostly undissolved chunks
• Saliva production = 0.3-0.4 mL/min normally, 1.5-2mL/min when stimulated
• You swallow reflexively every 1-2 minutes
• Within 2-5 minutes, >99% of the drug has washed down your esophagus into your stomach

The math: Even being extremely generous, maybe 0.1-0.5% absorbs sublingually before the rest goes down your throat. You're basically just doing oral administration with extra steps and a bitter taste.

The sublingual mucosa needs the drug to be in solution to absorb it. Undissolved crystals don't cross membranes (micronized raws may SLIGHTLY work)

The GI tract solves this with bile salts, dietary fats, massive surface area, and 30-60 minutes of contact time.

Your tongue has none of these advantages.

Problem #2: The Metabolism Claim Makes No Pharmacological Sense

Even if you somehow achieved 100% sublingual absorption (you can't), it wouldn't prevent mestanolone formation. Here's why:

The enzymes aren't just in your liver.

The conversion of oxymetholone to mestanolone happens via 5AR + 17b-HSD. These aren't liver-exclusive -- they're expressed in:

• Skeletal muscle (where you actually want the drug)
• Adipose tissue
• Skin
• Prostate
• Kidneys
• Throughout peripheral circulation

Once the drug enters your bloodstream (via ANY route), it circulates throughout your entire body and encounters these enzymes everywhere.

Changing the absorption route doesn't create a magical shield around the molecule.

This numpty is confusing two different concepts:

• First-pass metabolism = metabolism during initial absorption before reaching systemic circulation
• Systemic metabolism = ongoing metabolism after the drug is circulating

Sublingual can bypass first-pass (though anadrol already does this, as it's 17a).

It cannot prevent systemic metabolism because blood circulates. The drug passes through your liver ~once per minute during circulation. It's constantly exposed to metabolic enzymes in every tissue it reaches.

[0]: https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/oxymetholone.pdf

 

[Eddie.]

I'm going to blow a gasket.

I genuinely am going to create a YT channel and reveal my face if I have to, to combat the degree of sheer idiocy and harmful information clowns like these are spreading.

Hahaha that's why i quoted his name and his video and didn't just stated it, because i know the amount of bullshitery we've heard these past few years from different "peducators" is just too much. Sometimes i literally don't know what to believe or not. That's why i lately avoid most of that type of content.

Personally i haven't tried drol sublingually, anavar though did nothing full dose preworkout..it was just a waste of time having a powder under your tongue and try not to choke. Pills have to be specifically designed for subl. administration to get thr most out of it.

 

[BabaJagga]

Hahaha that's why i quoted his name and his video and didn't just stated it, because i know the amount of bullshitery we've heard these past few years from different "peducators" is just too much. Sometimes i literally don't know what to believe or not. That's why i lately avoid most of that type of content.

Personally i haven't tried drol sublingually, anavar though did nothing full dose preworkout..it was just a waste of time having a powder under your tongue and try not to choke. Pills have to be specifically designed for subl. administration to get thr most out of it.

ive tried var under tongue once. almost threw up. disguisting and not needed. just swallow that damn pillz...

 

[RockyP]

Sublingual orals...

Score another one for the "Do the exact opposite of what Todd Lee advises" school of PED use.

 

[ChemBB]

i know the amount of bullshitery we've heard these past few years from different "peducators" is just too much. Sometimes i literally don't know what to believe or not.

I just don't understand it.

I never believe anything someone tells me unless they have objective data/sources to back it up.

And nobody should ever believe anything I say unless I can back it up.

Either you say "I have data to verify this claim" or "I have no data for what I'm about to tell you so it's purely anecdote/conjecture."

We need to start demanding that every time one of these "educators"/"gurus" make a claim in a video, they link + cite the source they got it from.

Real quick we'd see a whole lot of crickets...

 

[ChemBB]

I'm in a spot where I'm fortunate enough to have a decent-paying job, so I can very well go in public and demolish these sorts of videos.

I don't need sponsors, subscribers, or to stay on anyone's good side. No motive except "You're all a bunch of idiots actively harming people, many of them young teens."

Chem YT channel incoming...

 

[RockyP]

I think the reason is that these guys have to feed the YT algo with something. We all know things haven't changed in decades since these drugs have been available. But along comes the era of social media and people monetizing clicks, now we have to constantly re invent the wheel. Very few of these guys have any real education on the matter, and even those who do talk out of their ass sometimes. I don't mean to discount anecdote, especially as things like controlled studies on guys taking grams of gear don't exist, but I agree 100% that the vast majority of what is out there is nonsense. I still think this forum is a great source of information with references when available.

I just don't understand it.

I never believe anything someone tells me unless they have objective data/sources to back it up.

And nobody should ever believe anything I say unless I can back it up.

Either you say "I have data to verify this claim" or "I have no data for what I'm about to tell you so it's purely anecdote/conjecture."

We need to start demanding that every time one of these "educators"/"gurus" make a claim in a video, they link + cite the source they got it from.

Real quick we'd see a whole lot of crickets...

 

[ChemBB]

I think the reason is that these guys have to feed the YT algo with something. We all know things haven't changed in decades since these drugs have been available.

I've thought a lot about this, and my $0.02 is that there are so many academics/researchers worth interviewing.

And there are constantly new papers coming out in journals about novel PED's, exercise science advances, biological/metabolic understanding, etc.

Just by keeping up with the rate of scientific progress you have a near-unending stream of content.

 

[RockyP]

I've thought a lot about this, and my $0.02 is that there are so many academics/researchers worth interviewing.

And there are constantly new papers coming out in journals about novel PED's, exercise science advances, biological/metabolic understanding, etc.

Just by keeping up with the rate of scientific progress you have a near-unending stream of content.

The problem is these morons can't converse on it / properly interview said experts because they don't have the scientific background to do so.

 

[Eddie.]

I'm with you on this but TBH from all those out there he's probably the only one with so many citations. I don't know if he can back up this particular story but generally he floods the description with dozens of references and citations.

When someone has been claimed by thousands of people as someone who knows his shit, the average Joe won't have second thoughts about the legitimacy of these things he heard or read. You expect at least being 85-90% accurate and not the other way.

Also, even if someone posts a research paper, citations and what not, you know that especially for a non native English speaking person it's hard to decipher a study, it requires some reading comprehension.

 

[ChemBB]

Also, even if someone posts a research paper, citations and what not, you know that especially for a non native English speaking person it's hard to decipher a study, it requires some reading comprehension.

I actually never considered that, that's a really good point.
Most of the world doesn't have English as a primary language even, I think.

Easy to forget...

 

[BabaJagga]

I'm with you on this but TBH from all those out there he's probably the only one with so many citations. I don't know if he can back up this particular story but generally he floods the description with dozens of references and citations.

When someone has been claimed by thousands of people as someone who knows his shit, the average Joe won't have second thoughts about the legitimacy of these things he heard or read. You expect at least being 85-90% accurate and not the other way.

Also, even if someone posts a research paper, citations and what not, you know that especially for a non native English speaking person it's hard to decipher a study, it requires some reading comprehension.

also, he seems like true nerd that likes to dig in to stuff. ive tried to watch few of his videos but its too hard to understand. too complicated words...

 

[Banana Joe]

also, he seems like true nerd that likes to dig in to stuff. ive tried to watch few of his videos but its too hard to understand. too complicated words...

He does seemingly often do so, for the sake of making it deliberately complicated, to impress a less knowledgeable audience.

... there are so many academics/researchers worth interviewing.
And there are constantly new papers coming out in journals about novel PED's, exercise science advances, biological/metabolic understanding, etc.
Just by keeping up with the rate of scientific progress you have a near-unending stream of content.

Maybe that would be the better approach, instead of storming onto YT with a chainsaw, to debunk those pseudo-science-frauds?

The same goes for exercise scientists that are not Schonfeld et al. I am sure there are ones out there that are worthy to be interviewed, but all we see is the usual clowns parading their worthless PhDs.
Fouad Abiad quite recently had a pretty unknown exercise scientist on his podcast, I there sure are more out there like him.

PS: With today's advanced video manipulation technology you could track your face and place a white rectangle over it, so you can anonymous!

 

[Banana Joe]

@Roger rabbit Has a methodology of dosing Adrol 3xdays followed by Var3xdays.
Seems to work in avoiding a fuck tonne of sides, including digestion issues/severe bloat.
a lot of us on Meso swear by this protocol like its scripture at this point.

Is this still a popular protocol? This is the first time I am reading about it.
I tried to find @Roger Rabbit's post on this, and it seems to kinda make sense, so I am wondering if that could be a way to prevent, or rather decrease, the appetite killing effect of orals, to which I am quite susceptible for.

 

[Dj11235813]

Kinda reporting back with some interesting and new findings, ended up using adrol for a bit earlier than expected for a month.
A bit of Mast really seems to help keep the bloat / water retention / edema i had prior (of course there are many lifestyle factors but it was very pronounced last time). I do not at all feel like a moon face water buffalo vs before when i used.

I personally think I bet a better "strength" boost taking it orally vs sublingually, where as I find anavar VERY effective sublingual, anadrol doesnt hit me the same. This could be the specific adrol pills I have, but i have used at least 4 brands of anavar sublingual with same technique and all effect me the same so I am not sure.. perhaps the liver conversion is truly important for adrol. Also of course this also means taking it minimum 1+ hours pre workout vs like 30 min (probably 2 is better)

I also feel that the adrol also needed more consistent daily use for the effects. Anavar i feel I can use like an energy drink at any point on any day for a "kick", i feel the adrol only really started to shine after regular almost daily use as if it needed to build up in my system.

I also only used it at 50mg this time, I don't think anything less is for me, and I ABSOLUTELY will be trying MORE when I use it again this winter LOL.

Overall, I liked it this experience. Some days I was like "DAMN im strong", some days were "hmm not getting much today". Weirdly like I said, I feel it needed to "build up" almost like an injectable.
My bloodwork DID take a hit, not scary, but its definitely not meant for LONG term use. I would say 4 weeks, totally fine, 6-8, maybe..
First time I used it, I wasn't impressed. This time, I liked it and can't wait to try 75-100mg.

Appreciate the follow up. This is a good insight! I was going back and forth with attempting it either sublingual or standard oral administration.

But i see @ChemBB already followed with some more info about it so I’ll stick with standard admin. I definitely don't want to waste the Abombs. I did only pick up 25mg, I saw some speculation that 50mg was potentially too high of a dose but that’s all anecdotal. We’ll see what works, I’ll report back.

 

[ChemBB]

I saw some speculation that 50mg was potentially too high of a dose

That is quite literally a women/children dose.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2004/16848s021lbl.pdf

DOSAGE AND ADMINISTRATION
The recommended daily dose in children and adults is 1-5 mg/kg body weight per day.

BB/PL'ing dose commonly 100mg, up to 200mg for brief periods pre-contest