accutane protocol questions

[john123321]

for anyone in this thread got access to scientific articles unblocked or whatever

Pharmacokinetics and dose finding of a potent aromatase inhibitor, aromasin (exemestane), in young males - PubMed

Suppression of estrogen, via estrogen receptor or aromatase blockade, is being investigated in the treatment of different conditions. Exemestane (Aromasin) is a potent and selective irreversible aromatase inhibitor. To characterize its suppression of estrogen and its pharmacokinetic (PK)...

pubmed.ncbi.nlm.nih.gov

e2 62% Max reduction

[Phase I single-dose administration study of exemestane in postmenopausal women] - PubMed

A single-dose administration study of a new type of aromatase inactivator, exemestane, was performed in normal healthy postmenopausal Japanese women. The study was conducted to investigate the safety, effect on serum and urinary estrogen concentrations, and pharmacokinetics of exemestane at 25...

pubmed.ncbi.nlm.nih.gov

2 weeks for e2 to return to normal IN WOMEN, should be shorter time period in men ofc

 

[john123321]

ah shit hes a child, isnt he?

my .org radar has been getting worse and worse recently, but if you are a child, up your E2 to ~20 at least, otherwise you will likely have problems with bone density and will be very injury prone (weaker joints/tendons, possibly for life), possibly also messing with torso/limb ratios (skinnier arms, wider torso) which looks horrible.


that is a dosage which can very much cause a good bit of acne during puberty.

I am not a child.

I do not know what your ".org radar" is, even 10pg/ml is considered a medically healthy level of e2, side effects are the best judge, controlling pth1r will reverse bone density problems and super compensate, wider clavicles with any combination of body parts (small arms, long torso) will always appear more aesthetic than the same configuration of limb lengths with a shorter biacromical width. Regardless, I do not care about what people think "looks horrible" as I am my own person and everyone has different types, who knows there may be one for me. life is too short to worry about arms and torso, just do what you want what makes you happy and what makes people in your life that you love happy.

I haven't started HGH yet so its not the cause of acne

 

[Mosoas]

e2 62% Max reduction

Did you even read this study?


How old are you? Have you at least checked your growth plates?

 

[john123321]

Did you even read this study?


How old are you? Have you at least checked your growth plates?

i did in fact read it, point to me my misundertanding. mean Max reduction was 62 but in extreme sd3 outliers 76 can occur

I am 18 or over, but I will not share my age.
I have gotten them checked in the tibia: they are open, albeit quite senescent. However growth plate scans are useless to see if your growth plates are open unless you x-ray the spine. Spinal growth plates stay open albiet in an extremely senescent state until ages 21-23. The clavicular growth plate closes around 21-25

 

[IndividualMan]

i did in fact read it, point to me my misundertanding. mean Max reduction was 62 but in extreme sd3 outliers 76 can occur

I am 18 or over, but I will not share my age.
I have gotten them checked in the tibia: they are open, albeit quite senescent. However growth plate scans are useless to see if your growth plates are open unless you x-ray the spine. Spinal growth plates stay open albiet in an extremely senescent state until ages 21-23. The clavicular growth plate closes around 21-25

widthmaxx? framemaxx? idk what it is called, but thats what you are probably doing

 

[synthetic_juggernaut]

"I will stick with 10IUs [of HGH]" - That seems like a (relatively) reasonable approach to hit your goals. It's around what pro bodybuilders run (compared to a conservative dose of 2-4) and aligns with dosages for children with idiopathic short stature.

The high-dose exemestane is definitely a risk that I wouldn't go for personally, but if you understand the risks and believe the benefits will outweigh it, then go for it. It definitely goes against the conventional wisdom, but you can be the guinea pig to get some valuable data for everybody. I'd be interested in seeing periodic blood tests along with a log detailing any negative effects (libido, joint pain, mental stuff) along with overall results (did you actually grow significantly more than projections based on parental height).

 

[john123321]

widthmaxx? framemaxx? idk what it is called, but thats what you are probably doing

just grow the bones man or something

 

[john123321]

"I will stick with 10IUs [of HGH]" - That seems like a (relatively) reasonable approach to hit your goals. It's around what pro bodybuilders run (compared to a conservative dose of 2-4) and aligns with dosages for children with idiopathic short stature.

The high-dose exemestane is definitely a risk that I wouldn't go for personally, but if you understand the risks and believe the benefits will outweigh it, then go for it. It definitely goes against the conventional wisdom, but you can be the guinea pig to get some valuable data for everybody. I'd be interested in seeing periodic blood tests along with a log detailing any negative effects (libido, joint pain, mental stuff) along with overall results (did you actually grow significantly more than projections based on parental height).

yeah I mean I know I'm just n=1 right now so my word doesent mean anything scientifically, but I am feeling no side effects, and I mean my mood changed for the better (this could also be from reta or just placebo idk or the fact that I'm losing weight pretty quickly).

I mean take it like this. all these old school, you know, "we go gym" type people would say things they know nothing about. I have looked at threads (not on here thankfully) of people saying EQ under 600 a week is "pointless" which is horribly incorrect.

people saying things based on years of anecdote, unsubstantiated by research, has created an unscientific environment of discourse where people either don't understand the drugs they put in their body or fear monger the drugs they don't put in their body.

anyway if you didn't ask you don't have to read this but on exe my mentality has improved, no joint pain, everything is fine. I also started a PSMF lyle mcdonald diet at 800 calories a day when I started exemestane and I'm chill

thanks

 

[AllbrandNew]

Yeah, I knew this seemed irregular to most but its for a reason.

going "too high" in melatonin doesn't really cause side effects worse than grogginess, and its a potent antioxidant with a wider range of action than glutathione. "What about reductive stress" I would be fine with a little bit of reductive stress if it means I stay healthy; with the compounds I am taking (accutane for now) oxidative stress can get pretty bad

so the high dose in exemestane is because one of my goals is to grow taller. a reduction in e2 will delay growth plate closure (and it will slightly increase test and LH but I don't expect anything from this). theoretically I don't need the exemestane as I will soon use compounds like abalo and other stuff influencing the pth1r to stop senescence in my growth plate, which is downstream from e2 signaling, but you know better safe than sorry. "your going to crush your estrogen" so exemestane is interesting it is a suicidal inhbitior, but most people dont know it CANNOT reduce e2 in men by more than 60% so no unless my e2 is extraordinarily low to begin with, it will not fall under 10pg/ml

anyway yeah I feel like a lot of bodybuilders should employ both melatonin and glutathione for oxidative stress if they are already not doing so, and AIs are very fear mongered except for in combination with things like EQ and some dht derivatives I don't know about those

60% Max reduction even if I took a gram of exemestane a day

I'm going by the 150mg/kg model which at 70kg is 10500

my acne was bad before and after I had started exemestane, I have heard accutane goes by kilogram so I'm not sure where you got this figure from, but I'm sure I'll hear about it from someone else.

yeah again I'm aiming for my e2 to be from 10-15pg/ml, exemestane might not even cut it to be honest, its a maximum 60% reduction in estradiol

thanks for the info on tudca

yeah it was 10500 actually using 150mg/kg
I have never had body acne, do you think I should do 220 anyway? or will doing 150 in one treatment and then 75-80 in another treatment if body acne becomes a problem later on. thanks for the info

what you say seems consistent with my all my friends who've taken it say. I guess the internet just amplified the worst 1% of situations

yeah I guess I saved up and I have been doing all this stuff with topical tretinoin, all these acne creams, for years and my face still always looks like shit, not horrible life-altering acne but its there and its obvious

well I have been on exemestane for two weeks at that dose, no bad side effects. was it bunk? probably not but I'll know when I get my first blood test

new aromatase synthesis reaches full concentration in a week, so I don't really understand where this weeks of bad side effects come from

brain issues will not occur; in monkeys, there was no change in e2 in the hippocampus and frontal cortex on 2.5mg of letrozole which is not a substrate of pGp and is still permeable to the BBB, so it should be the most detrimental to the brain but there was no effect. only in the amigdala did it change, likely due to e2 effect on emotions

so yeah exemestane is pretty safe on its own, yes 10-15 is low but it wont harm development neurologically, and no I will not "blast" growth hormone if "blasting" means 20IU, I will stick with 10IUs

the end has multiple means, and theoretically I shouldn't need to even control e2 if I control the pth1r but you know theory isn't everything so Im controlling both

thanks for the info, your solution sounds reasonable. I will probably do something like that, thanks again

for anyone in this thread got access to scientific articles unblocked or whatever

Pharmacokinetics and dose finding of a potent aromatase inhibitor, aromasin (exemestane), in young males - PubMed

Suppression of estrogen, via estrogen receptor or aromatase blockade, is being investigated in the treatment of different conditions. Exemestane (Aromasin) is a potent and selective irreversible aromatase inhibitor. To characterize its suppression of estrogen and its pharmacokinetic (PK)...

pubmed.ncbi.nlm.nih.gov

e2 62% Max reduction

[Phase I single-dose administration study of exemestane in postmenopausal women] - PubMed

A single-dose administration study of a new type of aromatase inactivator, exemestane, was performed in normal healthy postmenopausal Japanese women. The study was conducted to investigate the safety, effect on serum and urinary estrogen concentrations, and pharmacokinetics of exemestane at 25...

pubmed.ncbi.nlm.nih.gov

2 weeks for e2 to return to normal IN WOMEN, should be shorter time period in men ofc

I am not a child.

I do not know what your ".org radar" is, even 10pg/ml is considered a medically healthy level of e2, side effects are the best judge, controlling pth1r will reverse bone density problems and super compensate, wider clavicles with any combination of body parts (small arms, long torso) will always appear more aesthetic than the same configuration of limb lengths with a shorter biacromical width. Regardless, I do not care about what people think "looks horrible" as I am my own person and everyone has different types, who knows there may be one for me. life is too short to worry about arms and torso, just do what you want what makes you happy and what makes people in your life that you love happy.

I haven't started HGH yet so its not the cause of acne

We gotta get you on that mulit-quote train my friend.

 

[john123321]

We gotta get you on that mulit-quote train my friend

lol

 

[AlexDavis43]

so the high dose in exemestane is because one of my goals is to grow taller

wait how old are you

 

[AllbrandNew]

wait how old are you

Quick review of posts says under 21 for sure.