accutane protocol questions

[john123321]

for anyone in this thread got access to scientific articles unblocked or whatever

Pharmacokinetics and dose finding of a potent aromatase inhibitor, aromasin (exemestane), in young males - PubMed

Suppression of estrogen, via estrogen receptor or aromatase blockade, is being investigated in the treatment of different conditions. Exemestane (Aromasin) is a potent and selective irreversible aromatase inhibitor. To characterize its suppression of estrogen and its pharmacokinetic (PK)...

pubmed.ncbi.nlm.nih.gov

e2 62% Max reduction

[Phase I single-dose administration study of exemestane in postmenopausal women] - PubMed

A single-dose administration study of a new type of aromatase inactivator, exemestane, was performed in normal healthy postmenopausal Japanese women. The study was conducted to investigate the safety, effect on serum and urinary estrogen concentrations, and pharmacokinetics of exemestane at 25...

pubmed.ncbi.nlm.nih.gov

2 weeks for e2 to return to normal IN WOMEN, should be shorter time period in men ofc

 

[john123321]

ah shit hes a child, isnt he?

my .org radar has been getting worse and worse recently, but if you are a child, up your E2 to ~20 at least, otherwise you will likely have problems with bone density and will be very injury prone (weaker joints/tendons, possibly for life), possibly also messing with torso/limb ratios (skinnier arms, wider torso) which looks horrible.


that is a dosage which can very much cause a good bit of acne during puberty.

I am not a child.

I do not know what your ".org radar" is, even 10pg/ml is considered a medically healthy level of e2, side effects are the best judge, controlling pth1r will reverse bone density problems and super compensate, wider clavicles with any combination of body parts (small arms, long torso) will always appear more aesthetic than the same configuration of limb lengths with a shorter biacromical width. Regardless, I do not care about what people think "looks horrible" as I am my own person and everyone has different types, who knows there may be one for me. life is too short to worry about arms and torso, just do what you want what makes you happy and what makes people in your life that you love happy.

I haven't started HGH yet so its not the cause of acne

 

[Mosoas]

e2 62% Max reduction

Did you even read this study?


How old are you? Have you at least checked your growth plates?

 

[john123321]

Did you even read this study?


How old are you? Have you at least checked your growth plates?

i did in fact read it, point to me my misundertanding. mean Max reduction was 62 but in extreme sd3 outliers 76 can occur

I am 18 or over, but I will not share my age.
I have gotten them checked in the tibia: they are open, albeit quite senescent. However growth plate scans are useless to see if your growth plates are open unless you x-ray the spine. Spinal growth plates stay open albiet in an extremely senescent state until ages 21-23. The clavicular growth plate closes around 21-25

 

[IndividualMan]

i did in fact read it, point to me my misundertanding. mean Max reduction was 62 but in extreme sd3 outliers 76 can occur

I am 18 or over, but I will not share my age.
I have gotten them checked in the tibia: they are open, albeit quite senescent. However growth plate scans are useless to see if your growth plates are open unless you x-ray the spine. Spinal growth plates stay open albiet in an extremely senescent state until ages 21-23. The clavicular growth plate closes around 21-25

widthmaxx? framemaxx? idk what it is called, but thats what you are probably doing

 

[synthetic_juggernaut]

"I will stick with 10IUs [of HGH]" - That seems like a (relatively) reasonable approach to hit your goals. It's around what pro bodybuilders run (compared to a conservative dose of 2-4) and aligns with dosages for children with idiopathic short stature.

The high-dose exemestane is definitely a risk that I wouldn't go for personally, but if you understand the risks and believe the benefits will outweigh it, then go for it. It definitely goes against the conventional wisdom, but you can be the guinea pig to get some valuable data for everybody. I'd be interested in seeing periodic blood tests along with a log detailing any negative effects (libido, joint pain, mental stuff) along with overall results (did you actually grow significantly more than projections based on parental height).