Accutane permanent cure?

[pheno609]

He can potentially ask to start on a lower dose to avoid side effects and taper up, i dont think a dermatologist would be against this because many recommend isotrentinoin as a last resort if antibiotics and other methods dont work from what i read

 

[Ghoul]

The pharma isotretinoin will be gel caps, so you won't be able to break them down.

For anyone’s reference by the way, they go down to 5mg (a dose no longer available in US pharma), which I started using daily for general skin maintainance / anti-aging about 6 months after finishing the full Isotretinoin cycle. Makes a visible difference most noticeable in evenness of skin tone and reduction of fine wrinkles.

Accufine is 5/10/20/30/40 mg. A box of 100 5mg cost me ~$10 so $35 for a year’s supply vs $600-700 / yr to get it from the derms who prescribe it off label for anti aging. And they use 10mg eod, which can cause minor sides (dry lips) due to the peaks, vs daily 5mg which avoids that.

 

[k710]

Yeah I think the lowest dose I would get from the dermatologist would be 20mg (assuming in 1 capsule). Ill order some india pharma smaller doses to have on hand.

Maybe ill take the doc up on the 20mg and depending on my reaction guage if I go the micro or macro route while awaiting accufine. Worst case I save accufine for post treatment maintenance.

Feels kinda dumb to go from high to low instead of just starting low.. I just want to start already so I can be one dose closer to finishing. Feels like im siging up for torture camp to bring in the new year lol

 

[Ghoul]

Yeah I think the lowest dose I would get from the dermatologist would be 20mg (assuming in 1 capsule). Ill order some india pharma smaller doses to have on hand.

Maybe ill take the doc up on the 20mg and depending on my reaction guage if I go the micro or macro route while awaiting accufine. Worst case I save accufine for post treatment maintenance.

Feels kinda dumb to go from high to low instead of just starting low.. I just want to start already so I can be one dose closer to finishing. Feels like im siging up for torture camp to bring in the new year lol

At least it’ll be over by summer.

I don’t mention this enough, you are very very susceptible to sunburn when using high doses of Isotretinoin. Be careful.

 

[adrenalytic]

At least it’ll be over by summer.

I don’t mention this enough, you are very very susceptible to sunburn when using high doses of Isotretinoin. Be careful.

I think I saw this somewhere in the thread but don't recall the answer. Does MT2 use carry any risks when combined with accutane?

 

[Ghoul]

I think I saw this somewhere in the thread but don't recall the answer. Does MT2 use carry any risks when combined with accutane?

I don’t think anyone’s studied that. Mechanistically it doesn’t seem like they’d be connected despite both being skin related. MT2 doesn’t affect skin cells, just melanocytes. I did use them together for a short time, and an hour after the MT2 injection, 5 mins of sun exposure yielded much stronger tanning than MT2 would usually do with that protocol.

Was a foolish risk and don’t recommend it, but that was my experience.

 

[adrenalytic]

I don’t think anyone’s studied that. Mechanistically it doesn’t seem like they’d be connected despite both being skin related. MT2 doesn’t affect skin cells, just melanocytes. I did use them together for a short time, and an hour after the MT2 injection, 5 mins of sun exposure yielded much stronger tanning than MT2 would usually do with that protocol.

Was a foolish risk and don’t recommend it, but that was my experience.

Right on. I use 1-2 mg MT2 a week just so I don't turn into a pasty vampire during the winter. No tanning or sun, just maintenance of my tan from summer.

 

[Liter O' Test]

anyone have a domestic source thats decent?
last time i ran indian it was all cooked and degraded so it was a waste
i cbf testing or dealing with that shit or even waiting
pctzone wants $35 for 10 tablets of 20mg lol

 

[pheno609]

anyone have a domestic source thats decent?
last time i ran indian it was all cooked and degraded so it was a waste
i cbf testing or dealing with that shit or even waiting
pctzone wants $35 for 10 tablets of 20mg lol

I thought they were like 3.50 from pct zone, but i guess if you're including shipping. No matter who you order from you will have to pay shipping though. 24/7 has cheaper prices and i think there is a sale until the end of the month. Best to stock up to make the shipping worth it, you will need alot of accutane to meet the cumilative dose

 

[Ghoul]

anyone have a domestic source thats decent?
last time i ran indian it was all cooked and degraded so it was a waste
i cbf testing or dealing with that shit or even waiting
pctzone wants $35 for 10 tablets of 20mg lol

I don’t but I can tell you this is the time of year you can get it in good condition from India. To be extra sure, tell vendor you’re buying a lot, so make sure it’s “fresh”. The manufacturing date’s on the box. Last time I ordered in March, and it had a manufacturing date of January of the same year.

 

[Liter O' Test]

I thought they were like 3.50 from pct zone, but i guess if you're including shipping. No matter who you order from you will have to pay shipping though. 24/7 has cheaper prices and i think there is a sale until the end of the month. Best to stock up to make the shipping worth it, you will need alot of accutane to meet the cumilative dose

im looking for u.s domestic thats why price is higher

 

[pheno609]

im looking for u.s domestic thats why price is higher

Yeah you arent going to find cheap accutane domestic, its crazy expensive. You wont find pharma grade neither unless you get a perscription. I think everyone will agree that Indian pharma is the best option for accutane, super cheap and pharma grade. Youll spend thousands for domestic from UGLs with questionable quality

 

[williamboejer]

I've read one or two 6 month courses of Accutane can permanently cure acne in a lot of cases.

Has this worked permanently for anyone with steroid induced acne?

I suspect a permanent cure isn't for the steroid induced type, but I'd like to know if it's worth a try given the nasty sides or just stick to Doxycycline, which is effective and no sides but temporary.

It works it absolutely nukes acne my friend has been on It for a while due to acne he obtained it via prescription and has no visible acne even tho he is off it. Doctors also usually say you don't need to cycle it after doing one cycle

 

[Ghoul]

It works it absolutely nukes acne my friend has been on It for a while due to acne he obtained it via prescription and has no visible acne even tho he is off it. Doctors also usually say you don't need to cycle it after doing one cycle

Thanks, I finally got over the Accuphobia and saw the light. I can confirm your friends experience

 

[Lifting88]

Whats the min dose to shrink pores

Got some blackheads on nose and back

 

[2ndchancesNK]

Whats the min dose to shrink pores

Got some blackheads on nose and back

The higher the dosage, the sooner you will see the effect. The drug works on cumulative dosages, meaning the higher you dose the quicker you reach the upper ranges of cumulative.

120mg/kg-150mg/kg is what you will see most commonly prescribed in the clinical setting, whereas it’s likely 200mg/kg-300mg/kg is where you want to be for having the highest chance of avoiding relapse.

 

[2ndchancesNK]

Back to give another report — have been away from the forums for a few days because of the business of this time of year.

I danced in the 180mg-200mg range for a couple days and fuck that — you really feel the effects when it’s so damn cold and dry. If you’re a work from home person, it’s sustainable, otherwise the dryness of your lips, face, and not too mention the fatigue, are just brutal and require reapplying moisturizer and aquaphor by the hour.

I’m sticking in the 130mg-150mg range for the duration of treatment, but might take a stab again at that higher range later. For me, it wasn’t quite manageable.

Today was my 30th day where I have just hit the 3500mg total mark. I did 40mg for the first week before saying fuck it let’s speed this along.

I’m now running some UGL I picked up just incase my India package didn’t arrive in time. @Liter O' Test I will PM you.

All in all, this shit works. I have two bigger cysts (?) that haven’t really responded all that much that I’m a bit worried I’ll have to get excised, but I’m also keeping in mind that I’m only about 25% through the clinical cumulative dosage goal. Hoping I see better progress with those over the next month or two. Nonetheless, other spots are responding quick and fast to the drug.

Looking forward to seeing what changes happen in another 30 days.

 

[naps_for_gains]

120mg/kg-150mg/kg is what you will see most commonly prescribed in the clinical setting, whereas it’s likely 200mg/kg-300mg/kg is where you want to be for having the highest chance of avoiding relapse.

I ran 3 courses of prescribed accutane using the 120 mg/kg target, and it came back after every time. I still get acne, usually as a result of going overboard with food or fluctuations in estrogen, but it's mild and rare enough that I don't feel quite motivated to run another course.

If I did run it again, I would likely start with 0.5 mg/kg per day, possibly increasing to 1 mg/kg per day if side effects allow, with a target cumulative dose of 220 mg/kg.

This article appears to be a fairly decent and up-to-date summary of the relevant research: What Is the Risk of Relapse and Retrial With Isotretinoin for Acne?

 

[2ndchancesNK]

I ran 3 courses of prescribed accutane using the 120 mg/kg target, and it came back after every time. I still get acne, usually as a result of going overboard with food or fluctuations in estrogen, but it's mild and rare enough that I don't feel quite motivated to run another course.

If I did run it again, I would likely start with 0.5 mg/kg per day, possibly increasing to 1 mg/kg per day if side effects allow, with a target cumulative dose of 220 mg/kg.

This article appears to be a fairly decent and up-to-date summary of the relevant research: What Is the Risk of Relapse and Retrial With Isotretinoin for Acne?

Wow, I can’t imagine running 3 courses of this shit. Bravo for that, man.

Do you feel like even though you relapsed each time, your acne was overall less severe after each subsequent run in comparison to your first run?

That article is pretty on point I think. This drug clearly works at any dosage, but I think the pitfall of the low dose approach is the fact that people get clearance, but rarely reach that cumulative dose or end up just being on too long an deal with the unavoidable sides.

 

[naps_for_gains]

Do you feel like even though you relapsed each time, your acne was overall less severe after each subsequent run in comparison to your first run?

Yeah it got better each time, and luckily I got through them without any permanent or severe side-effects.