De Minimus: The End. 8/29

[BigDadd7]

Then what do you do when the few years are up?

Worry about it then

 

[sionnach]

Worry about it then

Or, yknow, be responsible and quit.

 

[Ghoul]

Or, yknow, be responsible and quit.

You're right, I'd better ditch Cilnidipine and defer to what the authorities (and anti edema compression sock makers), in all their wisdom of what's best for us, approve of, amlodipine.

 

[sionnach]

You're right, I'd better ditch Cilnidipine and defer to what the authorities (and anti edema compression sock makers), in all their wisdom of what's best for us, approve of, amlodipine.

View attachment 342764

Hehe. You know I meant quit the other stuff and hopefully resolve the problem causing the symptoms during the time of unavailability. But I appreciate the implications about Big Footwear. Those fuckers.

 

[BigDadd7]

Or, yknow, be responsible and quit.

Bruh... thats not going to happen. Lol

 

[BigDadd7]

You're right, I'd better ditch Cilnidipine and defer to what the authorities (and anti edema compression sock makers), in all their wisdom of what's best for us, approve of, amlodipine.

View attachment 342764

Very sexy

 

[sionnach]

Bruh... thats not going to happen. Lol

That's why I added the gif. I sure as hell ain't quittin. I don't have elephant legs though.

 

[woof]

Honestly, this is why I'd recommend anybody with a highschool-level science education and a willingness to experiment to research synthesis of testosterone from DHEA,

There are several routes that are either 2 or 3 step procedures that can be performed with nothing more than basic glassware, and common + legally available reagents.

For 2-step procedures, you have:

- NaBH4 + Activated MnO2
- NaBH4 + Oppenauer

And for 3 step, the "easy" route is:

- NaBH4 + TEMPO/NaOCl (Bleach) + HCl

Oppenauer might be a little trickier at home, but MnO2 or TEMPO should be cake for most people.

The high-level idea is the below, which has a billion resources online for each reaction:

1) Reduction of 17-Keto -> 17b-HO
2) Oxidation
3) Isomerize the 5 double bond -> 4 position

The 2-step procedures combine oxidation + isomerization

I know nothing of chemistry but I'd like to figure this out.

 

[Oswizzle]

EU couriers freeze US parcels as de minimis ends

EU couriers freeze US parcels as de minimis ends

trans.info

 

[Oswizzle]

How does this affect orders from China that are placed after the 29th?

 

[Ghoul]

How does this affect orders from China that are placed after the 29th?

No change, China lost de minimus months ago. .

The only impact this has on Chinese packs is a much higher proportion can be potentially inspected because of the lower overall volume, until mail status to flow from the places that paused.

 

[RockyP]

Just wanted to bump this to remind everyone that we were warned.

 

[Kingshit108]

You're not wrong and it has me thinking this might not matter. I'm concerned, but at the same time how long has the US been fighting and losing the "war on drugs?" Prices will probably go up and we won't have as many options, but this will never go away completely.

There's also a pretty good chance China will make some bullshit promise that'll never materialize but will give Trump a good headline and none of this will happen. Fingers crossed.

I know nothing of chemistry but I'd like to figure this out.

There's a synthesis from corn oil that produces testosterone and boldenone.i read about it long ago

 

[Ghoul]

There's a synthesis from corn oil that produces testosterone and boldenone.i read about it long ago

150 gallons of corn oil (best case scenario in an industrial plant) to 1kg Test base.

That's $2000 of highly purified corn oil, to start.

 

[ChemBB]

There's a synthesis from corn oil that produces testosterone and boldenone.i read about it long ago

I posted this in one of the doomsday threads.
Actually spent quite a bit of time on this, because of China situation.

The "realistic" kitchen-chemist way to produce Testosterone is from DHEA raws from Amazon.

All of the below can be done with basic glassware + easily available and cheap reagents.

1) Reduction of 17-Keto -> 17b-HO

The Effects of the Steroids 5-Androstenediol and Dehydroepiandrosterone and Their Synthetic Derivatives on the Viability of K562, HeLa, and Wi-38 Cells and the Luminol-Stimulated Chemiluminescence of Peripheral Blood Mononuclear Cells from Healthy Vo

In order to evaluate the role of substituents at 3-C and 17-C in the cytotoxic and cytoprotective actions of DHEA and 5-AED molecules, their derivatives were synthesized by esterification using the corresponding acid anhydrides or acid chlorides. As ...

pmc.ncbi.nlm.nih.gov

Dissolve DHEA in methanol/ethanol. Add NaBH4 slowly @ room temp, stirring.
Quench excess NaBH4 w/ HCl, then extract or evaporate.
Result: Androst-5-ene-3b,17b-diol
> "Synthesis of 5-androstenediol (2). To a solution of DHEA (14.00 g, 0.049 mol) in THF (150 mL), NaBH4 (2.38 g, 0.062 mol) was added at room temperature with stirring..."

2) TEMPO Catalyzed Oxidation

CN114315946A - Preparation method and application of steroid intermediate - Google Patents

The invention provides a preparation method and application of a steroid compound intermediate, and relates to the technical field of chemical synthesis. The method comprises the following steps: (a) carrying out oxidation reaction on the compound I under the action of a TEMPO catalyst...

patents.google.com

Dissolve diol intermediate in DCM.
Add small qty of aqueous sodium bicarb buffer
Add catalytic qty of TEMPO
Slowly add NaOCl dropwise, stirring vigorously @ room temp
Quench, separate organic layer, wash, evaporate
Result: 17b-hydroxyandrost-5-en-3-one
> 3b-HO steroid -> corresponding 3-keto using catalytic TEMPO + aqueous NaOCl + an alkali in a DCM/water biphasic system

3) Isomerize the 5 double bond -> 4 position
https://orgsyn.org/Content/pdfs/procedures/cv4p0195.pdf (note 14)
Dissolve product from (2) in EtOH
Add conc HCl dropwise
Either warm to ~40-50C for 30-60m, or just let it sit for a few hours
Neutralize with sodium bicarb
Extract w/ organic solvent
Result: Testosterone

-----

Second route, which is 2-step, combines Oxidation + Isomerization into a single step but requires Activated MnO2 or Oppenauer reaction, which is a bit messier and easier to fuck up.

1) Reduction of the 17-Keto to 17b-HO
Same as above, NaBH4 in MEtOH/EtOH

2) Oxidation of the 3b-HO Group + Double Bond Isomerization
Activated MnO2 in acetone, or Oppenauer oxidation (Al(O-i-Pr)3 with an aldehyde)

Admittedly my expertise is pharmacology/biochemistry >>> org chem, but I _think_ these both work "on paper".

150 gallons of corn oil (best case scenario in an industrial plant) to 1kg Test base.

That's $2000 of highly purified corn oil, to start.

Have a link for this out of curiosity?

 

[ChemBB]

150 gallons of corn oil (best case scenario in an industrial plant) to 1kg Test base.

That's $2000 of highly purified corn oil, to start.

Ah these are all biosynthesis methods

Those are unobtainium as far as kitchen chemistry is concerned, no use even looking at them unless you can get genetically engineered bacteria and have tons of bioreactors laying around... (and the knowhow to use them)

Single step biotransformation of corn oil phytosterols to boldenone by a newly isolated Pseudomonas aeruginosa - PubMed

A new potent <i>Pseudomonas aeruginosa</i> isolate capable for biotransformation of corn oil phytosterol (PS) to 4-androstene-3, 17-dione (AD), testosterone (T) and boldenone (BOL) was identified by phenotypic analysis and 16S rRNA gene sequencing. Sequential statistical strategy was used to...

pubmed.ncbi.nlm.nih.gov

 

[sionnach]

Ah these are all biosynthesis methods

Those are unobtainium as far as kitchen chemistry is concerned, no use even looking at them unless you can get genetically engineered bacteria and have tons of bioreactors laying around... (and the knowhow to use them)

Single step biotransformation of corn oil phytosterols to boldenone by a newly isolated Pseudomonas aeruginosa - PubMed

A new potent <i>Pseudomonas aeruginosa</i> isolate capable for biotransformation of corn oil phytosterol (PS) to 4-androstene-3, 17-dione (AD), testosterone (T) and boldenone (BOL) was identified by phenotypic analysis and 16S rRNA gene sequencing. Sequential statistical strategy was used to...

pubmed.ncbi.nlm.nih.gov

Especially using P. aeruginosa. Ew, no thanks.

 

[just some dude]

there’s still millions of packs going through, and there are tax/duty free lines applicable to the tariff policy. the problem is shitty companies. there’s always a way though.

 

[just some dude]

private sources will start to pop up more fs.

 

[Kingshit108]

private sources will start to pop up more fs.

Private sources used to be a lot more popular