Giant Semaglutide Thread (and other GLP-1 / GIP agonists)

[Doodle]

Wanted to create a thread where everyone can post their experiences with different sourced Semaglutide.

Who are you using?
Pharma vs non?
Dosage?
How long have you been taking it?
What are your thoughts?
Have you lost weight?
Side effects?
Oral vs injection?
Tests?

 

[Ghoul]

Hi all. I've been on glps for a while, but they don't seem to be doing much for me.
Currently on 20mg tirz, and I've been on it for at least a year, plus another year prior on Sema.

I initially lost about 10kg, but basically just stalled after.

Bought from QSC in the past, as well as SRY this time.

I get it that not every person responds the same, as well as upping the physical activity will help (just like with any attempt of losing weight)

Is there anything else i can try? Am i doing something wrong?

Sounds like you're a non-responder. It's genetic.

Sema's going to be offered in doses up to 7.2mg to address the issue of non-response. It's safe and the trials have demonstrated that all "non/weak responders" will eventually respond if the dose is high enough.

Where did you stop with Sema?
Did more weight loss happen once you switched to Tirz?

 

[pamperer]

Sounds like you're a non-responder. It's genetic.

Sema's going to be offered in doses up to 7.2mg to address the issue of non-response. It's safe and the trials have demonstrated that all "non/weak responders" will eventually respond if the dose is high enough.

Where did you stop with Sema?
Did more weight loss happen once you switched to Tirz?

Thanks Ghoul for taking this seriously
It was a while ago since i switched to Tirz, but I believe I did loose a little bit more.
I wouldn't mind trying Sema again, as long as it's not oral, i tried that for a month or so and got crazy heartburn, even taking PPIs.

I feel the Tirz is helping at 15-20mg, but not enough to actually lower weight, just to maintain.

 

[Ghoul]

Thanks Ghoul for taking this seriously
It was a while ago since i switched to Tirz, but I believe I did loose a little bit more.
I wouldn't mind trying Sema again, as long as it's not oral, i tried that for a month or so and got crazy heartburn, even taking PPIs.

I feel the Tirz is helping at 15-20mg, but not enough to actually lower weight, just to maintain.

You've got two options imo. You can either start adding .25mg Sema to your weekly Tirz protocol, and increase by .25mg every other week until you get sufficient suppression. This may not sound like much, but the synergistic effect of the two can be unexpectedly potent and you've got be cautious. Of course this is not a pharma protocol, but unlike other random GLP combinations, it's a sound approach and effective. It strengthens GLP-1 agonism and won't interfere with Tirz's mechanism of action.

Or, if you want a single injection. and an approved pharma protocol. switich over to 2.4 mg Sema, and titrate up every couple of weeks to a max of 7.4 mg.

"For individuals who did not achieve significant weight loss with the 2.4 mg dose, the 7.2 mg dose offers a more effective alternative. The increased dose led to a greater percentage of participants achieving substantial weight loss, indicating its potential to address the unmet needs of non-responders. "

STEP UP Trial Shows Semaglutide 7.2 mg Achieves Superior Weight Loss vs. 2.4 mg, Placebo | Applied Clinical Trials Online

Semaglutide 7.2 mg significantly outperformed semaglutide 2.4 mg and placebo with a 20.7% average reduction in weight and a comparable safety and tolerability profile, further establishing its efficacy in obesity treatment.

www.appliedclinicaltrialsonline.com

 

[pamperer]

You've got two options imo. You can either start adding .25mg Sema to your weekly Tirz protocol, and increase by .25mg every other week until you get sufficient suppression. This may not sound like much, but the synergistic effect of the two can be unexpectedly potent and you've got be cautious. Of course this is not a pharma protocol, but unlike other random GLP combinations, it's a sound approach and effective. It strengthens GLP-1 agonism and won't interfere with Tirz's mechanism of action.

Or, if you want a single injection. and an approved pharma protocol. switich over to 2.4 mg Sema, and titrate up every couple of weeks to a max of 7.4 mg.

"For individuals who did not achieve significant weight loss with the 2.4 mg dose, the 7.2 mg dose offers a more effective alternative. The increased dose led to a greater percentage of participants achieving substantial weight loss, indicating its potential to address the unmet needs of non-responders. "

STEP UP Trial Shows Semaglutide 7.2 mg Achieves Superior Weight Loss vs. 2.4 mg, Placebo | Applied Clinical Trials Online

Semaglutide 7.2 mg significantly outperformed semaglutide 2.4 mg and placebo with a 20.7% average reduction in weight and a comparable safety and tolerability profile, further establishing its efficacy in obesity treatment.

www.appliedclinicaltrialsonline.com

I actually had sema with tirz for a couple of weeks to i ran out, but i had an injury and was on tapentadol, which obviously messed up my gut movements, but i think i can combine them fine.

It might make sense (from a financial perspective) to lower the tirz to 10 or 15mg, and start adding sema until it works, and once i run out of tirz, reassess whether it's worth combining or go with Sema alone.

I might need to find a good cheap source for sema, if I'm going to be upping the dose significantly though.

 

[Ghoul]

I actually had sema with tirz for a couple of weeks to i ran out, but i had an injury and was on tapentadol, which obviously messed up my gut movements, but i think i can combine them fine.

It might make sense (from a financial perspective) to lower the tirz to 10 or 15mg, and start adding sema until it works, and once i run out of tirz, reassess whether it's worth combining or go with Sema alone.

I might need to find a good cheap source for sema, if I'm going to be upping the dose significantly though.

On a per mg basis it's essentially the same price as Tirz, and even if you needed the max 7.2, it's cheaper per dose.

 

[ineffectual]

Sema rebound 2-4 weeks after stopping is a motherfucker!

3 gallon tub of ice cream in the Walmart parking lot at 1am if he's not careful kind of sugar cravings type of insanity lol.

sounds like my life before glp1s

 

[Luke391]

Just shot my first tirz shot, 2.5mg at 3PM. It's now 8PM.

For those who felt already in the first shot, how long after the shot did you feel something? And what was it exactly?

Trying to be prepared for it if it comes.

I felt nothing on 2.5mg. On 5mg I started feeling fuller after meals smaller than usual and not as hungry/cravy in between meals, amd generally less food drive.
On the 2nd and 3rd week I'd get some bouts of stomach pain and nausea every once in a while. No side effects from the 4th week on, even as I increased the dose (now 10mg) never got side effects

 

[BrunoES]

I felt nothing on 2.5mg. On 5mg I started feeling fuller after meals smaller than usual and not as hungry/cravy in between meals, amd generally less food drive.
On the 2nd and 3rd week I'd get some bouts of stomach pain and nausea every once in a while. No side effects from the 4th week on, even as I increased the dose (now 10mg) never got side effects

You went from 2.5mg to 5mg in the second week?
What was your background, like weight, BF%, BMI, diet, etc?

 

[Luke391]

sounds like my life before glp1s

same

 

[Luke391]

yeah. I was always very much into lifting and dis cardio and was trying my best with diet but couldn't help but binge all the time because my hunger was insane.
I was probably 30% bodyfat, maybe higher.
Before that I had lost weight 3-4times naturally but gained it back every time because it was completely unsustainable. 30% bf was like the lowest I could maintain without crazy hunger.
I felt nothing on 2.5mg so I went to 5mg the second week. It worket great. only had some stomach pain and nausea on the 2nd and 3rd week then never any side effects again. I staued on 5mg for 4montha and then went to 10mg. Now I've been on 10mg for 3months I'd say. I'll probably up to 15mg or add Cagrilintide in a month or two.

You went from 2.5mg to 5mg in the second week?
What was your background, like weight, BF%, BMI, diet, etc?

 

[BrunoES]

yeah. I was always very much into lifting and dis cardio and was trying my best with diet but couldn't help but binge all the time because my hunger was insane.
I was probably 30% bodyfat, maybe higher.
Before that I had lost weight 3-4times naturally but gained it back every time because it was completely unsustainable. 30% bf was like the lowest I could maintain without crazy hunger.
I felt nothing on 2.5mg so I went to 5mg the second week. It worket great. only had some stomach pain and nausea on the 2nd and 3rd week then never any side effects again. I staued on 5mg for 4montha and then went to 10mg. Now I've been on 10mg for 3months I'd say. I'll probably up to 15mg or add Cagrilintide in a month or two.

Happy for you man, that you found a way to lose weight. Hope you get to where you want.

I have never really had a problem losing fat, wasn't hard to get to 7-8%, but independently of body fat, I always liked food, and only knew when to stop because I count my macros, if I were to rely on my brain to tell me when to stop, me too would be 30% BF lol

I noticed every time I got sick, and my appetite went away, my mind felt a lot freer. So I decided to hop on GLP-1s to try to emulate that feeling. I want to turn eating into the same as taking a shower. You take it because you know you need to, and sometimes it feels nice, and sometimes you prepare a bathtub if you want to enjoy it, but you don't really care about it most of the days lol

 

[Luke391]

Happy for you man, that you found a way to lose weight. Hope you get to where you want.

I have never really had a problem losing fat, wasn't hard to get to 7-8%, but independently of body fat, I always liked food, and only knew when to stop because I count my macros, if I were to rely on my brain to tell me when to stop, me too would be 30% BF lol

I noticed every time I got sick, and my appetite went away, my mind felt a lot freer. So I decided to hop on GLP-1s to try to emulate that feeling. I want to turn eating into the same as taking a shower. You take it because you know you need to, and sometimes it feels nice, and sometimes you prepare a bathtub if you want to enjoy it, but you don't really care about it most of the days lol

if you want mainly a "food noise" reduction Reta or Cagrilintide might be more usefull. it will lower your food drive without making you unable to eat.

 

[ChemBB]

Hi all. I've been on glps for a while, but they don't seem to be doing much for me.
Currently on 20mg tirz, and I've been on it for at least a year, plus another year prior on Sema.

I initially lost about 10kg, but basically just stalled after.

I was RX'ed Mounjaro about 2 years ago, and lost a ton of weight on it.
Recently did another cut using Sema/Tirz, lost 30lbs.

This last cut, they seem to be doing jack.

Running 8mg Reta, weight not dropping. Just added 1mg Sema because hunger is getting hard to ignore at night, too.

I'm on 2,600kcal avg, lifting 1hr/day, cardio 30min/day
Should be dropping weight like a fly but I'm not.

 

[BadandyB]

Looking for a little advice. 55y/o male with a BMI of 29.

During Covid I got Wegovy covered by insurance and it worked amazing. Now, no coverage for anything so I just started .5 of sema. Not feeling it yet, but it was the same way the first time. But aside from losing fat I also lost muscle and strength the first time. Appetite suppression is definitely something I need.

Should I stick with sema or move to tirz? Combine them? If I switch, do I need to add anything (cargi) to kill my appetite? I also want to add some GH to help maintain and/or grow muscle while I lose weight as well as help with muscle and joint stiffness/soreness in general. The first time I only took meds and never worked out. This time I have already started a resistance training program and WILL be sticking with it going forward. I am finally properly motivated to keep the weight off and build a more athletic and muscular physique.

Thanks!

 

[BrunoES]

if you want mainly a "food noise" reduction Reta or Cagrilintide might be more usefull. it will lower your food drive without making you unable to eat.

I am stuck with 300mg total of tirz now, too late lol. Also, cost/benefit is very good, and I rather prioritize safety over results in the position I am at in life right now, and tirz and sema are the only ones approved at this point in time.

 

[ChemBB]

But aside from losing fat I also lost muscle and strength the first time.

How did you lose muscle, assuming you lifted and were on at least 200-250mg Test?

Should I stick with sema or move to tirz? Combine them?

Tirz is better IME (I've run both RX Sema/Tirz, and UGL Sema/Tirz/Reta) but it's significantly more expensive.

You can get 10x10mg Sema vials cheaper than 10x10-20mg Tirz vials, where 2.5mg Sema is roughly equivalent to 15mg Tirz.

Just for the economics of it being 300-500% cheaper I tend to prefer Sema and just use really high doses if needed.

 

[ChemBB]

if you want mainly a "food noise" reduction Reta or Cagrilintide might be more usefull. it will lower your food drive without making you unable to eat.

Reta does fuckall for hunger

Run it from multiple sources, even 8-10mg doesn't feel like I'm taking anything to suppress hunger.

Sema/Tirz both work great for this, for me. Can't speak for Cagri, I think it's kind of a ripoff for the price.

 

[BadandyB]

How did you lose muscle, assuming you lifted and were on at least 200-250mg Test?

At that time all I did was take the sema. No lifting, no exercise, no diet restrictions. Lost 80 pounds in 6 months.

Tirz is better IME (I've run both RX Sema/Tirz, and UGL Sema/Tirz/Reta) but it's significantly more expensive.

You can get 10x10mg Sema vials cheaper than 10x10-20mg Tirz vials, where 2.5mg Sema is roughly equivalent to 15mg Tirz.

Just for the economics of it being 300-500% cheaper I tend to prefer Sema and just use really high doses if needed.

That was kind of what I was thinking, but as someone new there is sooooo much out there and on here about all these different combinations it is a bit overwhelming.

Thank you for your reply!

 

[BadandyB]

Reta does fuckall for hunger

Run it from multiple sources, even 8-10mg doesn't feel like I'm taking anything to suppress hunger.

Sema/Tirz both work great for this, for me. Can't speak for Cagri, I think it's kind of a ripoff for the price.

Sema/Tirz both work great for this, for me. Can't speak for Cagri, I think it's kind of a ripoff for the price.

I do see Cagri is NOT cheap! lol

 

[Luke391]

Anyone can attest to the fact that Cagri has more of a mental effect on appetite suppresion? Like less food drive and food noise?
I can eat a lot of clean low calorie foods and feel my stomach physically full, but the mental drive to eat and craving are really strong still and never really subside, even with coffee, or chewing gum.
So I was tihinking Cagri would be more effective at reducing the mental drive to eat rather than upping the Tirz to 15mg? Costwise it's not that bad. 10x10mg vials of Cagri are like 150-200$. Even at the max dose of 2.5mg (which I doubt I'll need, I think around 1mg will likely suffice) that's only 5$ a week. not gonna break the bank, I'll probably save more than 5$ a week on food if it gets me to not binge on junk.