Triptorelin messed me up. Help Needed

I did try low dose naltrexone but to be honest I didn’t give it a full go. I gave up after a few doses. I need to actually try it some for time to see if it can help me. Thanks for the other recommendations, if you can rank them from order of effectiveness and priority for my situation how would you? Thank you in advance.
Ntrexone takes time. you have to use it for 3-6 months to see improvement, especially long lastong improvement. start a 1.5mg twice a week and up the dose as needed until 9mg twice a week maximum.
The other supplements and peptides I listed are hard to rank since there's a lot of individual variability. I'd say start with Methylene blue since it can be very beneficial. Then look into adding Ubiquinol, Injectable Carnitine and NAD.
If that is still not enough look at the other 3
 
I do have a psychiatrist, she thinks my physical symptoms are unrelated to mental and told me to work with my PCP on that end.
Here in the US, Lexapro 5mg is only used for titrating up to 10mg. The minimum effective dose is usually 10mg.

I'd get a second opinion for that reason alone.
 
Here in the US, Lexapro 5mg is only used for titrating up to 10mg. The minimum effective dose is usually 10mg.

I'd get a second opinion for that reason alone.
Just seen my PCP and she said it sounds like I have fibromyalgia. She said the first line of treatment for that is tricyclic antidepressants. What are your thoughts on that?

Also spoke with her about giving TRT a go. She told me about the fertility risk (which I already know about) and wants me to speak about it with the endo. Did some fresh blood work for testosterone, free testosterone, etc given that it was low in March so we’ll see what happens. Will keep you guys posted.
 
Just seen my PCP and she said it sounds like I have fibromyalgia. She said the first line of treatment for that is tricyclic antidepressants. What are your thoughts on that?

Also spoke with her about giving TRT a go. She told me about the fertility risk (which I already know about) and wants me to speak about it with the endo. Did some fresh blood work for testosterone, free testosterone, etc given that it was low in March so we’ll see what happens. Will keep you guys posted.
Do Low Dose Naltrexone for fibromyalgia. I want to do the same
 
Did a fresh blood test last week July 28th. Free and bioavailable testosterone came back low again.

Just spoke with my endo and she gave me the standard fertility risk disclaimer and told me that my low testosterone is due to my excessive weight gain. I told her I’m fatigued all the time, I have muscle weakness and I don’t even have the energy to lift weights at all and she prescribed me jardiance and phentermine.

She wants my body to produce more testosterone on its own and think trt will cause more issues down the road .. Guess she doesn’t think higher testosterone will help with inflammatory cytokines either.

I’ve been pretty strict on my diet and doing brisk walks the past few weeks, and a few pushups and squats here and there, which is the most exercise I can do at the moment. I have some enclomiphene from an online clinic that I think I’m going to run for 6 weeks and see what happens.

Also I seen a new GI and told him about my gastro issues. I can’t even eat in the daytime without crashing ( feeling extremely exhausted, heavy heart palpitations and needing to nap or lay down for a few hours ) and he said it’s not normal and wants to help me get back to being able to eat like a normal person. He ran an abdominal xray and seen that I have a lot of stool backed up. Also ordered a gastric emptying study for me.

I have a list of supplements that I ordered but only going to try them one by one as my body is extremely sensitive and reactive. Starting with Enclomiphene.
 

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Did a fresh blood test last week July 28th. Free and bioavailable testosterone came back low again.

Just spoke with my endo and she gave me the standard fertility risk disclaimer and told me that my low testosterone is due to my excessive weight gain. I told her I’m fatigued all the time, I have muscle weakness and I don’t even have the energy to lift weights at all and she prescribed me jardiance and phentermine.

She wants my body to produce more testosterone on its own and think trt will cause more issues down the road .. Guess she doesn’t think higher testosterone will help with inflammatory cytokines either.

I’ve been pretty strict on my diet and doing brisk walks the past few weeks, and a few pushups and squats here and there, which is the most exercise I can do at the moment. I have some enclomiphene from an online clinic that I think I’m going to run for 6 weeks and see what happens.

Also I seen a new GI and told him about my gastro issues. I can’t even eat in the daytime without crashing ( feeling extremely exhausted, heavy heart palpitations and needing to nap or lay down for a few hours ) and he said it’s not normal and wants to help me get back to being able to eat like a normal person. He ran an abdominal xray and seen that I have a lot of stool backed up. Also ordered a gastric emptying study for me.

I have a list of supplements that I ordered but only going to try them one by one as my body is extremely sensitive and reactive. Starting with Enclomiphene.
maybe seems like a combination of a strong autoimmune response skyrocketing your systemic inflammation combined with poor digestion and poor insulin sensitivity.
I already mentioned the mitochondrial efficiecy peptides but with this info I think it would also be beneficial to look into anti-inflammatories and aids for gut health.
A few things you migh wanna check on:
for inflammation:
high dose vitamin C
Nac + Glycine or injectable glutathione
high dose melatonin
high dose EPA
BPC157, TB500 and KPV
for gut aid:
Glutamine
Butyric acid (could be extremely beneficial)
fiber supplements (like phsyllium husk powder)
Apple cider vinegar
oral BPC157 and TB500
Probiotics

I would sit out on the enclomophine since high bodyfat + encomophine is like a perfect storm for high estrogen which could make everything worse. I'd rather try a bit of Metformin or a low dose of Tirzepatide/Retatrutide to improve your insulin sensitivity and loose some bodyfat. These also help lower inflammation.

Testosterone is important but it's not always about Testosterone. I feel like you are putting TRT on a pedistal as if higher free test will solve all your problems. it migh help your low energy levels a little but it might also make many other things worse
 
maybe seems like a combination of a strong autoimmune response skyrocketing your systemic inflammation combined with poor digestion and poor insulin sensitivity.
I already mentioned the mitochondrial efficiecy peptides but with this info I think it would also be beneficial to look into anti-inflammatories and aids for gut health.
A few things you migh wanna check on:
for inflammation:
high dose vitamin C
Nac + Glycine or injectable glutathione
high dose melatonin
high dose EPA
BPC157, TB500 and KPV
for gut aid:
Glutamine
Butyric acid (could be extremely beneficial)
fiber supplements (like phsyllium husk powder)
Apple cider vinegar
oral BPC157 and TB500
Probiotics

I would sit out on the enclomophine since high bodyfat + encomophine is like a perfect storm for high estrogen which could make everything worse. I'd rather try a bit of Metformin or a low dose of Tirzepatide/Retatrutide to improve your insulin sensitivity and loose some bodyfat. These also help lower inflammation.

Testosterone is important but it's not always about Testosterone. I feel like you are putting TRT on a pedistal as if higher free test will solve all your problems. it migh help your low energy levels a little but it might also make many other things worse
I think the easiest things you could try rn are Butyric acid + Glutamine + Fiber for your gut
BPV157 + TB500 + KPV for the inflammation and muscle pain
Metformin for the poor insulin sensitivity (indicated by the crashes after you eat)
Methylene blue to improve your mood and brain fog
 
maybe seems like a combination of a strong autoimmune response skyrocketing your systemic inflammation combined with poor digestion and poor insulin sensitivity.
I already mentioned the mitochondrial efficiecy peptides but with this info I think it would also be beneficial to look into anti-inflammatories and aids for gut health.
A few things you migh wanna check on:
for inflammation:
high dose vitamin C
Nac + Glycine or injectable glutathione
high dose melatonin
high dose EPA
BPC157, TB500 and KPV
for gut aid:
Glutamine
Butyric acid (could be extremely beneficial)
fiber supplements (like phsyllium husk powder)
Apple cider vinegar
oral BPC157 and TB500
Probiotics

I would sit out on the enclomophine since high bodyfat + encomophine is like a perfect storm for high estrogen which could make everything worse. I'd rather try a bit of Metformin or a low dose of Tirzepatide/Retatrutide to improve your insulin sensitivity and loose some bodyfat. These also help lower inflammation.

Testosterone is important but it's not always about Testosterone. I feel like you are putting TRT on a pedistal as if higher free test will solve all your problems. it migh help your low energy levels a little but it might also make many other things worse
I do agree with your first sentence that’s exactly what I think it is.

I’ve tried ozempic and mounjaro. They both make me feel awful. Also tried oral bpc, high dose vitamin C, nac, and injectable glutathione, high dose pea, nac, glycine, and high dose melatonin.

It’s like my body sets off an immune reaction when I try most supplements. I get bloated, bad mood, and very fatigued when I try most supplements. When I did my cycle I was on 600mg test, my results came back at over 7k ng/dl. I’ve come to the conclusion that I’m very sensitive to supplements/medication. I’m gonna keep trying things but I’m gonna go the low dose route for now on.

Thanks for offering another perspective. Maybe I am putting testosterone on a pedestal, I’ve been dealing with these issues for years so it felt relieving to see something abnormal to attach to and see if getting it sorted will make me feel better.

Was talking with chat gpt and they suggested Mega IgG2000 to reduce immune overactivation, and support the mucosal barrier so will be trying that when it arrives this week.
 
I do agree with your first sentence that’s exactly what I think it is.

I’ve tried ozempic and mounjaro. They both make me feel awful. Also tried oral bpc, high dose vitamin C, nac, and injectable glutathione, high dose pea, nac, glycine, and high dose melatonin.

It’s like my body sets off an immune reaction when I try most supplements. I get bloated, bad mood, and very fatigued when I try most supplements. When I did my cycle I was on 600mg test, my results came back at over 7k ng/dl. I’ve come to the conclusion that I’m very sensitive to supplements/medication. I’m gonna keep trying things but I’m gonna go the low dose route for now on.

Thanks for offering another perspective. Maybe I am putting testosterone on a pedestal, I’ve been dealing with these issues for years so it felt relieving to see something abnormal to attach to and see if getting it sorted will make me feel better.

Was talking with chat gpt and they suggested Mega IgG2000 to reduce immune overactivation, and support the mucosal barrier so will be trying that when it arrives this week.
in that case definetly sounds like autoimmune response + hyper sesnitivity.
You're doing the right thing by trying things one by one to see how you respond. I said to not tale the Enclo becaise given this hypersensitivity higher test, estrogen, prolactin and progesterone from it might get you a very strong reaction.
Looking to regulate your immunen system sounds like the right thing then.
I know people have success with autoimmune diseases by going on carnivore diets or doing prolonged fasing. idk if you trird that.
Low Dose Naltrexone might help a bit since some of your pain might be caused by the myelin sheath around the neurons, which when overactive releases excessive amounts of inflammatory chemicals that signal to the neurons to feel pain.
LDN should reduce this inflammatory response by the myelin sheath
 
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Just seen my PCP and she said it sounds like I have fibromyalgia. She said the first line of treatment for that is tricyclic antidepressants. What are your thoughts on that?

Also spoke with her about giving TRT a go. She told me about the fertility risk (which I already know about) and wants me to speak about it with the endo. Did some fresh blood work for testosterone, free testosterone, etc given that it was low in March so we’ll see what happens. Will keep you guys posted.
Fibromyalgia is a psychiatric disorder.
 
I do agree with your first sentence that’s exactly what I think it is.

I’ve tried ozempic and mounjaro. They both make me feel awful. Also tried oral bpc, high dose vitamin C, nac, and injectable glutathione, high dose pea, nac, glycine, and high dose melatonin.

It’s like my body sets off an immune reaction when I try most supplements. I get bloated, bad mood, and very fatigued when I try most supplements. When I did my cycle I was on 600mg test, my results came back at over 7k ng/dl. I’ve come to the conclusion that I’m very sensitive to supplements/medication. I’m gonna keep trying things but I’m gonna go the low dose route for now on.

Thanks for offering another perspective. Maybe I am putting testosterone on a pedestal, I’ve been dealing with these issues for years so it felt relieving to see something abnormal to attach to and see if getting it sorted will make me feel better.

Was talking with chat gpt and they suggested Mega IgG2000 to reduce immune overactivation, and support the mucosal barrier so will be trying that when it arrives this week.
Obviously, it is not rational that GLP-1s and every supplement under the sun is going to have a causal relationship with your subjective feelings of distress - your experiences are, in essence, delusional and not real.

But, many drugs like GLP-1s make you feel worse before they make you feel better. This is famously the case for antidepressants.

I'm going to suggest an antipsychotic if antidepressants do not help you. They will help you think and feel more rationally. Something like Abilify would be a good first choice.
 
Fibromyalgia is a psychiatric disorder.
not necessarly. There is a thing called a myelin sheath around the neurons. This is responsable for releasing pro-inflammatory molecules that signal to the neuron to feel pain. In people with fibromyalgia this myelin sheath is overactive and is producing too much of thes signal molecules
 
Obviously, it is not rational that GLP-1s and every supplement under the sun is going to have a causal relationship with your subjective feelings of distress - your experiences are, in essence, delusional and not real.

But, many drugs like GLP-1s make you feel worse before they make you feel better. This is famously the case for antidepressants.

I'm going to suggest an antipsychotic if antidepressants do not help you. They will help you think and feel more rationally. Something like Abilify would be a good first choice.
why are you so adamant about him getting on phych meds? anyphychotinlcs are not small things. it would he much safer and likely more effective to try and reduce inflammation with supplements and peptides than psychiatroc drugs with serious repercussions in the long and short term
 
I do agree with your first sentence that’s exactly what I think it is.

I’ve tried ozempic and mounjaro. They both make me feel awful. Also tried oral bpc, high dose vitamin C, nac, and injectable glutathione, high dose pea, nac, glycine, and high dose melatonin.

It’s like my body sets off an immune reaction when I try most supplements. I get bloated, bad mood, and very fatigued when I try most supplements. When I did my cycle I was on 600mg test, my results came back at over 7k ng/dl. I’ve come to the conclusion that I’m very sensitive to supplements/medication. I’m gonna keep trying things but I’m gonna go the low dose route for now on.

Thanks for offering another perspective. Maybe I am putting testosterone on a pedestal, I’ve been dealing with these issues for years so it felt relieving to see something abnormal to attach to and see if getting it sorted will make me feel better.

Was talking with chat gpt and they suggested Mega IgG2000 to reduce immune overactivation, and support the mucosal barrier so will be trying that when it arrives this week.
have you ever checked your microplastics saturation, heavy metal levels and checked for possible mold poisoning/exposure? Many sympoms could be due to high heavy metals or mold toxins.
When there isn't an apparent cause for somebody's syntoms we like to call them crazy and shut them up with meds.
 
have you ever checked your microplastics saturation, heavy metal levels and checked for possible mold poisoning/exposure? Many sympoms could be due to high heavy metals or mold toxins.
When there isn't an apparent cause for somebody's syntoms we like to call them crazy and shut them up with meds.
Yeah I'm definitely not crazy. My doc ran a lead blood test which came back normal, didn't test for any other heavy metals. I have done a hair mineral analysis and mycotoxin blood/urine test. Some values did come back abnormal however I'm not sure on the validity of those tests.

Never checked microplastics saturation.
 
Yeah I'm definitely not crazy. My doc ran a lead blood test which came back normal, didn't test for any other heavy metals. I have done a hair mineral analysis and mycotoxin blood/urine test. Some values did come back abnormal however I'm not sure on the validity of those tests.

Never checked microplastics saturation.
generally Glucarate supplements (like AAKG, Ca-AKG and Calcium-D-Glucarate), high fiber intake, Sulforaphane, probiotics, Chlorella and sweating a lot, like a sauna, are effective at clearing out microplastics and enviromental toxins
 
copper? hows your diet?
best thing to do is literally not take any medication or supplements at all and eat as clean as possible without restricting food groups
 
copper? hows your diet?
best thing to do is literally not take any medication or supplements at all and eat as clean as possible without restricting food groups
My copper is high and zinc has been low/low normal. My current diet is fasting until about 3pm then I’ll have 4-5 slices of turkey bacon, 2 eggs, half an avocado, and 2 slices of bread. Snack is usually a fruit. Dinner is grilled chicken with rice and cabbage or radish. Then I’ll have a vegan protein shake sometimes with a banana or whatever else I need to get in my calories for the day. Currently eating about 1700 calories.
 

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generally Glucarate supplements (like AAKG, Ca-AKG and Calcium-D-Glucarate), high fiber intake, Sulforaphane, probiotics, Chlorella and sweating a lot, like a sauna, are effective at clearing out microplastics and enviromental toxins
I can’t do too much fiber or else I’ll feel awful, bloating, feet swelling, and heart palpitations. I just started incorporating a little fiber from fruits and cooked veggies. Used to be able to eat apples no problem but it bloats me up badly now. I have tried sulforaphane and chlorella. Probiotics straight up crash me. I’ll look into glucurate.
 
Hey guys, currently 29 years old. I was on gear, just testosterone from 2018-2019. PCTed during covid in 2020 with clomid, and took some letro as my e2 got high.

Things were going decent and I decided to take 100mcg of a non-pharmaceutical version of triptorelin to finish off the pct. After this injection my health has not been the same since. I developed a wave of strange symptoms that have persisted to this day.

My symptoms:
  • Severe fatigue and muscle weakness
  • Burning in hands and feet
  • Excessive weight gain
  • Exercise intolerance ( my muscles literally shake and burn when I flex them. It feels like I just finished a 2 hour workout when I haven't done anything at all)
  • Hot flashes and cold extremities
  • Heart palpitations, especially after eating
  • Severe gut dysfunction – tight, distended stomach and bloating
  • No ability to sweat
  • Extreme supplement sensitivity – even mild ones cause overstimulation or crashes
  • Chronic anxiety and panic episodes
  • Elevated inflammatory markers (TNF-alpha, Interleukins) and Candida IgE was elevated
  • High insulin levels ( tried ozempic and mounjaro but feel awful taking them )
  • Feel completely disconnected from my body, like my nervous system is broken


I’ve tried 100s of different supplements, some peptides, lifestyle changes, and seen both conventional and functional doctors, but nothing has fully resolved this. Oddly enough, when I tried pharmaceutical triptorelin much later with vitamin b5 and b6, some symptoms temporarily improved — like sweating, energy, and calm. I was also able to exercise — but once it wore off, things got worse again. I tried this because I thought maybe it would reset my hpta. It clearly didn't stick.

I've even gotten 2 colonoscopie due to the gut issues. My stool also isn't the same consistency as it was before the injection. It's paler and very messy now. Done 100s of other tests and gotten little to no answers. I had mild anxiety moments in the past but never anything serious until this. Now I'm taking 5mg of lexapro for it. I just seen a naturopath and they think that it's mold toxicity which I'm not to sure about but I'm open to trying anything at this point.


It feels like something in my neuroendocrine or gut-brain axis was deeply disrupted. All hormones are normal. Some providers think this may be a form of CIRS, neuroinflammation, or autonomic nervous system injury. Idk if the triptorelin was contaminated, or my body was already dealing with some weakness and the triptorelin was the straw the broke the camels back.



If anyone else has experienced something similar from triptorelin or other peptides, or if you’ve found anything that helped repair the damage, or doctors that I can see, I’d really appreciate hearing from you. I’m trying to stay hopeful and piece together answers. 6 years of my life wasted due to one injection.



Thank you.
Sounds almost exactly the same as when I had long covid. It could be a coincidence that it kicked in after a med. ME/CFS and LC have a lot of overlap of symptoms. I had mast cell activation, dysautonomia, gastroparesis and a raft of other symptoms. Intolerance to heat, cold and any form exercise. Became allergic to a whole host of things. Palpitations, random racing heart and veins would puff up for no reason.

For the food and other allergies I did H1+H2 antihistamine + ketotifen.

Low dose Naltrexone works for some. Nicotine patches are effective for some people. Maraviroc has the best results.

Took 3 years to recover
 
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