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AllGoodThings said:
I respect you for questioning the science, and I will say I've only parroted what I was able to read through searching, and it seemed quite settled than the brain makes its own cholesterol. you likely have a much better understanding of this than I do. I know much of brain science is more speculation than irrefutable, concrete fact.
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I do not.

I can accept that certain cells (maybe all cells) have vestigial capability of producing cholesterol, but the evolution of specialization (and acquisition from the environment - i.e. eating) means it can't be the only method and doesn't make sense that it would be the primary method.

I have for a long time found discussions of cholesterol miss the forrest through the trees. It is the one biological substance that differentiates plants from animals, and it's pretty important.

All of that said, my understanding of biology and biochemistry is 20 years out of date. I don't mean to come across as a prick. I just like to employ socratic reasoning, within the context of what I know to be unquestionably true.

I also have a mother with Alzheimer's, and did a massive amount of research Summer of 2021 when she was first diagnosed. Some of this came up within the context of then cutting edge drug development, like Aduhelm, which has since proven to be bunk.
 
eryximachus said:
I do not.

I can accept that certain cells (maybe all cells) have vestigial capability of producing cholesterol, but the evolution of specialization (and acquisition from the environment - i.e. eating) means it can't be the only method and doesn't make sense that it would be the primary method.

I have for a long time found discussions of cholesterol miss the forrest through the trees. It is the one biological substance that differentiates plants from animals, and it's pretty important.

All of that said, my understanding of biology and biochemistry is 20 years out of date. I don't mean to come across as a prick. I just like to employ socratic reasoning, within the context of what I know to be unquestionably true.

I also have a mother with Alzheimer's, and did a massive amount of research Summer of 2021 when she was first diagnosed. Some of this came up within the context of then cutting edge drug development, like Aduhelm, which has since proven to be bunk.
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Sorry about your mother, but if I were you that would worry me for myself, too, in case the cause is partially genetic . . .
 
eryximachus said:
I do not.

I can accept that certain cells (maybe all cells) have vestigial capability of producing cholesterol, but the evolution of specialization (and acquisition from the environment - i.e. eating) means it can't be the only method and doesn't make sense that it would be the primary method.

I have for a long time found discussions of cholesterol miss the forrest through the trees. It is the one biological substance that differentiates plants from animals, and it's pretty important.

All of that said, my understanding of biology and biochemistry is 20 years out of date. I don't mean to come across as a prick. I just like to employ socratic reasoning, within the context of what I know to be unquestionably true.

I also have a mother with Alzheimer's, and did a massive amount of research Summer of 2021 when she was first diagnosed. Some of this came up within the context of then cutting edge drug development, like Aduhelm, which has since proven to be bunk.
Click to expand...
I'm sorry to hear about your mom, I hope she's doing okay. There's nothing like an unwell loved one to motivate us to research health topics. I did something similar with pain, pain processing, and pain killing methods and drugs for the sake of my wife. The brain is overwhelmingly complex, and there's so much we don't understand.
 
eryximachus said:
I do not.

I can accept that certain cells (maybe all cells) have vestigial capability of producing cholesterol, but the evolution of specialization (and acquisition from the environment - i.e. eating) means it can't be the only method and doesn't make sense that it would be the primary method.

I have for a long time found discussions of cholesterol miss the forrest through the trees. It is the one biological substance that differentiates plants from animals, and it's pretty important.

All of that said, my understanding of biology and biochemistry is 20 years out of date. I don't mean to come across as a prick. I just like to employ socratic reasoning, within the context of what I know to be unquestionably true.

I also have a mother with Alzheimer's, and did a massive amount of research Summer of 2021 when she was first diagnosed. Some of this came up within the context of then cutting edge drug development, like Aduhelm, which has since proven to be bunk.
Click to expand...
I read brain PET scans (FDG, and mostly Vizamyl and Amyvid), and did consulting work for Eli Lily during development of Amyvid. There are new monoclonal Ab drugs targeting amyloid plaque and they do work in reducing it, alas with potential serious side effects including brain hemorrhages. And the feedback I've been getting from the neurologists who send us these cases is that the clinical improvements are not significant. And it goes without saying the drugs are very expensive - they may well end up breaking the already collapsing healthcare system.

Anyway only mentioning this as Amyvid/Vizamyl scans typically show findings of Alzheimer's disease decades before symptoms develop... a good number of people in the control group in the original studies (young people without symptoms ie paid volunteers) who had positive scans ultimately did develop symptoms. FDG scans have been around much older and are typically only positive when symptoms are well established, somewhere beyond 'mild cognitive impairment".

Not sure I would want to know the results if I had an abnormal scan while healthy. Anyway I am sorry to hear about your mom... it's a really difficult diagnosis to manage.
 
Hi everyone we still haven’t received any official statement from India post or other postal services regarding resume of mail service , it’s taking longer than anticipated as American authorities are not sharing guidelines with postal services of other nations as well ,

UAE post official will be sharing any possible updates on Monday or Tuesday with us , UAE post packages that showing in transit may take longer to update due to USPS non compliance attitude currently.

We are always here to provide best possible services to our customers and any solid update will be share as soon available, we will be accepting new orders only when we have clear guidelines from post services .

Email - shop@pct24x7.store

Thanks & Regards
PCT24X7
 
malfeasance said:
Sorry about your mother, but if I were you that would worry me for myself, too, in case the cause is partially genetic . . .
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I think in her case it was due to substantial life time use of anticholinergic drugs. I try to tell everyone I know to avoid such drugs, especially as so many are prescribed needlessly. And many others are OTC (like Benadryl)

Controlling blood pressure is also extremely important.

But, it certainly has informed my use of PEDs. I have little desire to live into my 70s, if that is the outcome.
 
bigdaddyandfriends said:
I read brain PET scans (FDG, and mostly Vizamyl and Amyvid), and did consulting work for Eli Lily during development of Amyvid. There are new monoclonal Ab drugs targeting amyloid plaque and they do work in reducing it, alas with potential serious side effects including brain hemorrhages.
Click to expand...

I think the issue is that the hypothesis that the plaques are the cause of dementia is false. It appears the plaques are a consequence of dementia, perhaps a way to defend against it. But we just don't know. What we do know is removing the plaques has no impact on dementia behavior or cognitive decline.
bigdaddyandfriends said:
And the feedback I've been getting from the neurologists who send us these cases is that the clinical improvements are not significant. And it goes without saying the drugs are very expensive - they may well end up breaking the already collapsing healthcare system.
Click to expand...
This is why Aduhelm was pulled from the market quickly. It too was extremely costly.
bigdaddyandfriends said:
Anyway only mentioning this as Amyvid/Vizamyl scans typically show findings of Alzheimer's disease decades before symptoms develop... a good number of people in the control group in the original studies (young people without symptoms ie paid volunteers) who had positive scans ultimately did develop symptoms. FDG scans have been around much older and are typically only positive when symptoms are well established, somewhere beyond 'mild cognitive impairment".

Not sure I would want to know the results if I had an abnormal scan while healthy. Anyway I am sorry to hear about your mom... it's a really difficult diagnosis to manage.
Click to expand...
I've been treating my mother at a major, famous hospital and they have never mentioned these scans, and plenty have been done. I would suspect they are experimental or otherwise not widely available.

But I would not want to know.
 
eryximachus said:
I think the issue is that the hypothesis that the plaques are the cause of dementia is false. It appears the plaques are a consequence of dementia, perhaps a way to defend against it. But we just don't know. What we do know is removing the plaques has no impact on dementia behavior or cognitive decline.

This is why Aduhelm was pulled from the market quickly. It too was extremely costly.

I've been treating my mother at a major, famous hospital and they have never mentioned these scans, and plenty have been done. I would suspect they are experimental or otherwise not widely available.

But I would not want to know.
Click to expand...

increasingly called Type 3 diabetes, insulin resistance in the brain is seen as a major factor in neurodegeneration. In terms of prevention, another reason to get on, and stay on GLPs, which significantly improve brain metabolism and insulin sensitivity, along with reducing inflammation, another likely contributor.
 
AllGoodThings said:
I would imagine I'm not the only one that finds this infuriating. "here are a bunch of new (bullshit) rules you must all follow. No, we won't explain the details"
So ridiculous, yet entirely unsurprising.
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CharlesV said:
DC probably hasn’t even worked out the details yet. they had concepts of the details and left boots on the ground to scramble and figure out the logistics.
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The requirements are exactly the same that existed for packages to the US that didn't qualify for de minimus because they were valued over $800.

Only the threshold has changed, down to $100 (and must be a gift).

Any package over $800 needed full customs paperwork and duties had to be collected. This is nothing new. Most countries never even offered "de minimus" exemptions and require full customs paperwork for every package.

What's jammed things up is the scale, The postal systems weren't prepared to deal with every $5 package requiring the same full customs processing that previously applied to $800+ packages.

Commercial shippers like DHL, FedEx, and UPS had no problem adapting because they use modern systems to handle the paperwork and are used to collecting duties for most packages they ship, unlike primitive post offices (which they all seem to be including USPS) that are decades behind in technology.
 
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Ghoul said:
Commercial shippers like DHL, FedEx, and UPS had no problem adapting because they use modern systems to handle the paperwork and are used to collecting duties for most packages they ship, unlike primitive post offices (which they all seem to be including USPS) that are decades behind in technology.
Click to expand...
Why aren't international sellers using DHL or FedEx? I would pay extra for next day delivery.
 
Ghoul said:
increasingly called Type 3 diabetes, insulin resistance in the brain is seen as a major factor in neurodegeneration. In terms of prevention, another reason to get on, and stay on GLPs, which significantly improve brain metabolism and insulin sensitivity, along with reducing inflammation, another likely contributor.
Click to expand...
I plan to stay on GLP-1 drugs indefinitely.
 
eryximachus said:
Why aren't international sellers using DHL or FedEx? I would pay extra for next day delivery.
Click to expand...
DHL , FedEx ask for COA and lot of paperwork even when we tried to send samples to janoshik , using them is not possible at all here in India , postal services of other nations are working on adapting the rules though but they needed some time which they weren’t allowed, Hope this gets resolved soon that’s why I stopped accepting orders as I can’t simply take money from people while there is no time frame / guidelines provided by postal services
 
PCT24X7 PHARMACY said:
DHL , FedEx ask for COA and lot of paperwork even when we tried to send samples to janoshik , using them is not possible at all here in India , postal services of other nations are working on adapting the rules though but they needed some time which they weren’t allowed, Hope this gets resolved soon that’s why I stopped accepting orders as I can’t simply take money from people while there is no time frame / guidelines provided by postal services
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Yesterday the "United Postal Union", which is the international organization that sets standards for how international mail is exchanged between countries announced it has worked with US Customs to develop software that will allow post offices to automate paperwork and calculate customs duties due for US bound packages. It's being distributed to all 192 member countries now and is expected allow packages to resume moving very soon.

Press Release: UPU launches solution to move mail as postal flows to US reach near standstill

6 September (Berne, Switzerland) – The Universal Postal Union (UPU) – the UN specialized agency for global postal cooperation – has started deploying a solution to help postal operators resume delivery to the United States after postal traffic to the country dipped more than 80% following its...
www.upu.int www.upu.int
 
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