Got my order in 15 days: pitavastatin, ivabradine, and Bempesta EZ all showed up like clockwork. Switched things around, dropping from 10 mg rosu to 2 mg pita plus 10 mg Bempesta EZ. Bloodwork’s in 2-3 weeks and I’m honestly curious to see what the numbers say. Either I’ll pat myself on the back for being smarter than my cardiologist, or I’ll find out I just paid good money to fast-track my own obituary.
You're being smarter than your cardiologist. 4mg pitavastatin is a closer match for 10mg rosuvastatin (mg for mg, pitavastatin is 1.7x as potent) but the difference in efficacy between 2-4mg pitastatin and 5-10mg rosuvastatin is surprisingly small, above those doses returns start diminishing fast. And 2mg pitavastatin will have a better effect on HDL than 10mg rosuvastatin, not to mention improving insulin sensitivity. Beneficial collateral effects of statins are also more pronounced with pitavstatin, being lipophilic rather than hydrophilic.
I personally can't/won't use bempedoic acid because of my kidney stone history (calcium oxalate stones like most, but they essentially all have a uric acid nidus) - but am very interested in seeing how it works for you. Anyone here who has landed in the ER with an obstructing stone will agree with me on this!
Bempedoic acid is not a commonly prescribed drug. I would say that if you're not already using ezetimibe it should be the second-line cholesterol drug after a statin as it has no side effects in most people; however a few do get GI problems from it which may preclude its use. On its own it is a fairly weak cholesterol drug, but it considerably potentiates the effects of statins making them a very synergistic combination - just like test and tren. On my perma-cruise / light cycle, 10mg rosuvastatin and 10mg ezetimibe (plus 8mg cardarine and 30mg SR9009) kept my HDL ~ 40 and LDL ~ 47... which puts me at ease regarding plaque development from PEDs. And this is with me not eating great; while I don't eat processed crap, I also don't live on chicken and rice, my wife and I both like restaurant food so we consume a lot of sodium and fat. As a reference, without any PEDs or cholesterol drugs, my LDL was in the 140s, with HDL as low as 14 (high carb / low fat diet) to 53 (high fat / low carb diet). I've stayed on high fat / low carb most of my life because of this. I also learned early on trigs are directly related to excess carbohydrate intake, rather than fat intake - basically they are excess carbs packaged by the liver into triglycerides to be transported via blood to be taken up and stored in adipose. On a high carb low fat diet mine were > 500; now they are <50 with a restricted carb diet (generally only carbs flank my workouts) and tren, which seems to drop them considerably and also improve hgA1c. I seriously think low dose trenbolone would be more effective than most pharma drugs for Type II DM. I'd prescribe it off label for that, if I could. I had a client that I 'cured' his type II DM with low dose tren + reta. One point here is that different people require different diets, I do best on a high fat, moderate protein, low carb (not keto) diet; typically dairy carb intake is 100gm only.
For those on exogenous hormones, basically the lower the LDL the better, goal should be < 55. I see a lot of posts on social media, including some by 'doctors', claiming that LDL is good for you, it's needed by the brain, people with low LDL have shorter life expectancies, statins are poison, etc. That is flat out misinformation - the brain manufacturers its own cholesterol as needed and (slight drop) in test and other hormone and vitamin D levels from very low LDL are a non-issue when exogenous hormones and D3/K2 are administered. Everyone should be supplementing D3/K2 in the 5,000-10,000iu per day range; the US RDA is the amount needed to keep children from getting rickets, not for optimal adult health; D3 levels should in the 70-90 range on blood work. And while there is enough K2 in D3/K2 supplements to prevent depletion, megadosing K2 is highly worthwhile - I use Koncentrated K 25mg/day, plus about 500mcg that comes with the 10,000iu D3. I have not even gotten a cold in the last few hours years since start 10,000iu D3 per day, and I don't take flu or other vaccines; I almost lost my medical privileges over refusing the 'jabs' back in 2021, even though I work from home.
www.fda.gov
