MESO-Rx Exclusive Unique characteristics of oxandrolone

[ToesOverKnees]

What mental feel and sides do you all get from var ?

 

[BabaJagga]

What mental feel and sides do you all get from var ?

exactly none. maybe slight boost in focus with 50mg preworkout 30-45min before.
other than that 0.

 

[ManK]

BOOM! Article dropped! Thanks, @Millard!

Oxandrolone at 20 mg daily decreased visceral adipose tissue (-20.9 +/- 12 cm(2); P < 0.001), abdominal sc adipose tissue (SAT) declined (-10.7 +/- 12.1 cm(2); P = 0.043), the ratio VAT/SAT declined from 0.57 +/- 0.23 to 0.49 +/- 0.19 (P = 0.002), and proximal and distal thigh SC fat declined [-8.3 +/- 6.7 cm(2) (P < 0.001) and -2.2 +/- 3.0 kg (P = 0.004), respectively].

Oxandrolone at 10 mg daily for 7 days increased fasting 3-hydroxybutyrate [a marker for hepatic ketogenesis] by 70% and 3-hydroxybutyrate AUC by 53% after oral fat loading.

We know that AR dose/response is logarithmic and according to Forbes, 1985, doses up to 1,000 mg/w are not S-shaped (sigmoidal function), but if an androgen's sole mechanism is AR agonism, then an inflection point should occur at some point > 1,000 mg/w [that has never been directly measured].

Since this effect on fat mass is mediated by hepatic ketogenesis via oxandrolone effects on triaglycerol lipase, and the doses used are low, we can't infer or assume the shape of the dose/response curve without more data.

That is to say, that while 20 - 40 mg daily is a rough optimization of tolerability/efficacy trade-offs, considering muscle protein anabolism via the AR activity that is bounded by inherent hepatotoxicity of oxandrolone, we cannot say that hepatic ketogenesis does not continue unabated at higher doses.

But practically, since hepatic ketogenesis is directly related to HTGLA (the breakdown of lipoproteins from larger to smaller more atherosclerotic ones), we need to balance the benefit vs. the dyslipidemic cost.

what about kidney stress from oxandrolone?

Thank you

 

[BabaJagga]

what about kidney stress from oxandrolone?

Thank you

check other oxandrolone thread in this section, i just posted bloodwork before and after.

 

[trtchin]

I just ran it for 5 weeks for the first time on top of a regular TRT dose. I was coming out of a long cut into maintenance calories and I had just gotten an abdominal ultrasound whcih was good to go so I thougth what the hell I never tried Anavar before and I had some.

Started with 5 mg per day for a couple days, then 10, then 20 by the end of the week split into two doses. Did 20 mg again for week 2. For weeks 3-5 did 30 mg per day.

Def felt like I got some results during that time.

Didnt get a blood test immediately after stopping but got it 2 weeks later. All liver values within range and super low TBH. I was taking 1,600 mg NAC daily and 500 mg Tudca. BUN was high but not crazy high, GFR and Creatinine all in range.

HDL dropped a bit, and LDL went from 103 to 120 but I guess that will come down.

Interestingly Iron was elevated and not sure I think its from the Anavar? Although I didnt test Iron for a while. Hermatacrit had dropped since I last tested it only at 47.

 

[Type-IIx]

what about kidney stress from oxandrolone?

Thank you

The belief that Anavar is uniquely metabolized by the kidneys not the liver is a myth promulgated by a book of science fiction titled Andropathy written by RAS Hemat in 2007.

Anavar is metabolized extensively by the liver like all 17AAs but does pose some risk to nephrons on par with other moderately-potent nonaromatizable drugs, such as stanozolol (Winstrol)… probably less than Winstrol, actually, given Winny’s long activity extended by its pyrazole ring.

Kidney function isn’t something to dismiss, it’s just that Anavar has about an average risk versus something like trenbolone on the more extreme end and testosterone on the other.

 

[Eddie.]

The belief that Anavar is uniquely metabolized by the kidneys not the liver is a myth promulgated by a book of science fiction titled Andropathy written by RAS Hemat in 2007.

Anavar is metabolized extensively by the liver like all 17AAs but does pose some risk to nephrons on par with other moderately-potent nonaromatizable drugs, such as stanozolol (Winstrol)… probably less than Winstrol, actually, given Winny’s long activity extended by its pyrazole ring.

Kidney function isn’t something to dismiss, it’s just that Anavar has about an average risk versus something like trenbolone on the more extreme end and testosterone on the other.

And what could be the reason for so many reports (perhaps a dozen on this board) of acute kidney pain while using oxandrolone? Maybe other compounds stress nephrons the same or worse but haven't heard anyone having pain while on winstrol or even tren.

 

[ManK]

The belief that Anavar is uniquely metabolized by the kidneys not the liver is a myth promulgated by a book of science fiction titled Andropathy written by RAS Hemat in 2007.

Anavar is metabolized extensively by the liver like all 17AAs but does pose some risk to nephrons on par with other moderately-potent nonaromatizable drugs, such as stanozolol (Winstrol)… probably less than Winstrol, actually, given Winny’s long activity extended by its pyrazole ring.

Kidney function isn’t something to dismiss, it’s just that Anavar has about an average risk versus something like trenbolone on the more extreme end and testosterone on the other.

I had alway higher creatinine value after a cycle on test+var then after a cycle with test+tren

 

[Type-IIx]

And what could be the reason for so many reports (perhaps a dozen on this board) of acute kidney pain while using oxandrolone? Maybe other compounds stress nephrons the same or worse but haven't heard anyone having pain while on winstrol or even tren.

Gas?

IDK, what's a dozen reports blaming trenbolone for getting caught on camera getting railed by a tranny tell you?

Probably more than some generalized feelings of kidney pain… And how you make the leap from these vague reports to Var Killz Kidneys is beyond me.

Just couldn't tell ya, but probably gas.

 

[Type-IIx]

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I had alway higher creatinine value after a cycle on test+var then after a cycle with test+tren

Yup, 17AAs, and particularly oxandrolone, increase creatine stores and creatinine biosynthesis. It's partly why it's so strength-promoting. It's not particularly renotoxic, though. For people walking around with > 27 kg/m^2 FFMI (muscular), and training with weights a few days a week, creatinine is a meaningless measure, like it's correlates and proxies.

Biomarkers are useful for most people, generally. Generally, resistance training has not been a pursuit undertaken by the average person. Now, with a health and fitness surge in popularity… *licks thumb, puts in the air* I think we're gonna see a lot more of these turnin' up here, sarge.

 

[BabaJagga]

Yup, 17AAs, and particularly oxandrolone, increase creatine stores and creatinine biosynthesis. It's partly why it's so strength-promoting. It's not particularly renotoxic, though. For people walking around with > 27 kg/m^2 FFMI (muscular), and training with weights a few days a week, creatinine is a meaningless measure, like it's correlates and proxies.

Biomarkers are useful for most people, generally. Generally, resistance training has not been a pursuit undertaken by the average person. Now, with a health and fitness surge in popularity… *licks thumb, puts in the air* I think we're gonna see a lot more of these turnin' up here, sarge.

i agree that creatinine isnt much usefull marker but my cystatinin c clearly risen after 8 weeks at 50mg var daily. in other thread in this section i posted results for comparison. do you have any other explanation why?

 

[Type-IIx]

i agree that creatinine isnt much usefull marker but my cystatinin c clearly risen after 8 weeks at 50mg var daily. in other thread in this section i posted results for comparison. do you have any other explanation why?

It could be hepatorenal strain from oxandrolone, nothing I've said suggests otherwise bro! It's just average risk, you might be susceptible to hepatorenal disorders, acute or chronic kidney diseases, etc. That's an entirely separate matter from attempting to diagnose kidney disease or failure, anything whatsoever, based on vague pain sensations from internet self-reports rife with confirmation biases and hasty generalizing.

 

[BabaJagga]

It could be hepatorenal strain from oxandrolone, nothing I've said suggests otherwise bro! It's just average risk, you might be susceptible to hepatorenal disorders, acute or chronic kidney diseases, etc.

not tryin to say you are wrong, im just gathering more info, dont take it like insult ofc.
its a shame that such great drug has this mechanism built in. but it is what it is

 

[readalot]

not tryin to say you are wrong, im just gathering more info, dont take it like insult ofc.
its a shame that such great drug has this mechanism built in. but it is what it is

50 mg/d Brother. Never prescribed like that. Pay to play.

 

[Type-IIx]

not tryin to say you are wrong, im just gathering more info, dont take it like insult ofc.
its a shame that such great drug has this mechanism built in. but it is what it is

The only irritating thing about this conversation is this very post, I have not taken anything as insulting… now, however, I do fairly take your characterizing me as defensive to be ridiculous.

What mechanism do you refer to?

 

[BabaJagga]

The only irritating thing about this conversation is this very post, I have not taken anything as insulting… now, however, I do fairly take your characterizing me as defensive to be ridiculous.

What mechanism do you refer to?

i just dont wanna sound like im tryin to strt an argument like many people here like to do.

50 mg/d Brother. Never prescribed like that. Pay to play.

yes, fuck around and find out as i like to say.

 

[Ateam2023]

fight fight fight

 

[BabaJagga]

fight fight fight

no.

 

[Ateam2023]

no.

i was just being a "Richard"

 

[Humble-Beast]

Oxo 25mg one week in.. holy shit, I love it!
Strength and weights went up already, just noticing some extra leanness as well.
I'm liking possibly better than tren cause I'm getting super full and lean while feeling like I can take on Godzilla or some shit, lol. No sleep, acid reflux, erection, or mental side effects. Hope it lasts.
I ran it a few years ago when I was at probably 30%+ body fat and looking for a miracle, lol. It was ehh nice, but now at maybe 12% body fat and it's a completely different experience. I can't believe it's only been one week.