well if your coach said so.
MESO-Rx
Anabolic Steroids
Injectable NAD+ --- Anyone try these applications?
- Thread starter Max Magnus
- Start date
Here we go..
New here so " Hi"first. I'm in week 10 of a kinda sort a blast for me and running IM glutathione, reta (SQ) and IM NAD along with some other sups to see how my bloods came in. I'm 50 and cut down significantly to get to a spot to run some get back into it legit dosages.
Anyway bloods came in over the top green. Arguably better than I have been off gear ever.
Was getting a bit pricey so while I started at 600x2 of glutathione and 500 NAD a week but had to go every 2nd week. Ran reta at 1 mg every 5 days. APO B .8 , even off gear my hdls are low and they stayed exactly the same. Crit was 48, what else can I tell you..... Liver and kidney markers no indication of stress in anyway. Doc couldn't believe the labs especially when total T was 197/5600.SHGB 18 , estrogen 50 and prolactin 2.7. I'm Canadian if some of the numbers seem weird.
So I am a believer in the protocol. I personally disagree with the NAD has no bioavailability IM. I literally felt awful almost immediately after pinning for about 30 minutes. Something was going on and fast. Been out of the game a while trt for a couple years but never had labs look that good ever. It's locked in for me for any future blasts and even cruise.
Looking forward to lots of great information and conversation.
Cheers
The old guy
Anyway bloods came in over the top green. Arguably better than I have been off gear ever.
Was getting a bit pricey so while I started at 600x2 of glutathione and 500 NAD a week but had to go every 2nd week. Ran reta at 1 mg every 5 days. APO B .8 , even off gear my hdls are low and they stayed exactly the same. Crit was 48, what else can I tell you..... Liver and kidney markers no indication of stress in anyway. Doc couldn't believe the labs especially when total T was 197/5600.SHGB 18 , estrogen 50 and prolactin 2.7. I'm Canadian if some of the numbers seem weird.
So I am a believer in the protocol. I personally disagree with the NAD has no bioavailability IM. I literally felt awful almost immediately after pinning for about 30 minutes. Something was going on and fast. Been out of the game a while trt for a couple years but never had labs look that good ever. It's locked in for me for any future blasts and even cruise.
Looking forward to lots of great information and conversation.
Cheers
The old guy
Max Magnus
New Member
Did you watch the Video's I put up... ?
I did but only yesterday when I got on Meso
Max Magnus
New Member
It's my understanding that IM NAD+, is done just like a regular AAS (oil based). The Video shows Greenfield doing 'Push IV' ... which one are you doing?
I'm doing shallow IM. Read a paper someone mentioned, Vigorous Steve maybe do not recall for certain on the merits of shallow IM for GH. The data was compelling enough for me to switch my pre-workout GH pin. The spike, at least in this study was much higher than SQ.
So this was the protocol we mapped out for both glutathione and NAD.
So this was the protocol we mapped out for both glutathione and NAD.
Steve does everything SubQ now, and says if he could go back in time he would have done everything, both oil-based and peptides as SubQ to avoid mobility issues and adhesions from aggregate IM pinning scars over the years.
It simply comes down to absorption timing, and NAD, Glutathione & GH are all beneficial regardless of absorption speed. None of them are pre-workouts (although yes arguments could be made if you're pinning north of 4 IU GH 4-5 hours pre-workout to time a spike for max growth for contest prep) so as Steve would say "Just shut the f*ck up and get it in."
Also in the Koniver video above he explains 100mg NAD+ subQ daily 5-on-2-off as a reasonable 2nd place for his preference (which is understandable as his clinic makes more when they come in for an IV).
Ya so maybe it was someone else, I felt like I addressed that. I was sharing what I did....and my results on labs.
Understood. Still reasonable to put it out there that unless you're dying to pin IM you will reap max benefit from all of the above via subQ. To each their own.
Stealth500
Member
i think these are the 2 studies they are referring to in the article.
CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism
Juliana Camacho-Pereira et al. Cell Metab. 2016.
CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism - PubMed
Nicotinamide adenine dinucleotide (NAD) levels decrease during aging and are involved in age-related metabolic decline. To date, the mechanism responsible for the age-related reduction in NAD has not been elucidated. Here we demonstrate that expression and activity of the NADase CD38 increase...
pubmed.ncbi.nlm.nih.gov
CD73 protein as a source of extracellular precursors for sustained NAD+ biosynthesis in FK866-treated tumor cells
Alessia Grozio et al. J Biol Chem. 2013.
CD73 protein as a source of extracellular precursors for sustained NAD+ biosynthesis in FK866-treated tumor cells - PubMed
NAD(+) is mainly synthesized in human cells via the "salvage" pathways starting from nicotinamide, nicotinic acid, or nicotinamide riboside (NR). The inhibition with FK866 of the enzyme nicotinamide phosphoribosyltransferase (NAMPT), catalyzing the first reaction in the "salvage" pathway from...
pubmed.ncbi.nlm.nih.gov
View attachment 343622
i think these are the 2 studies they are referring to in the article.
CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism
Juliana Camacho-Pereira et al. Cell Metab. 2016.
CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism - PubMed
Nicotinamide adenine dinucleotide (NAD) levels decrease during aging and are involved in age-related metabolic decline. To date, the mechanism responsible for the age-related reduction in NAD has not been elucidated. Here we demonstrate that expression and activity of the NADase CD38 increase...
CD73 protein as a source of extracellular precursors for sustained NAD+ biosynthesis in FK866-treated tumor cells
Alessia Grozio et al. J Biol Chem. 2013.
CD73 protein as a source of extracellular precursors for sustained NAD+ biosynthesis in FK866-treated tumor cells - PubMed
NAD(+) is mainly synthesized in human cells via the "salvage" pathways starting from nicotinamide, nicotinic acid, or nicotinamide riboside (NR). The inhibition with FK866 of the enzyme nicotinamide phosphoribosyltransferase (NAMPT), catalyzing the first reaction in the "salvage" pathway from...
So the injected NAD+ is rapidly broken down and absorbed in cells as NAM, adenosine, and NMN, essentially fast-tracking precursor absorption that would need to withstand digestion and synthesis in the gut if taken as an oral supplement. Makes sense. I'm not sure what the downside is based on this data.
$1.45 a dose and I feel amazing. Let's say it's placebo that the 30+ supplements I take do not provide for some reason. What would that be worth to you?
sionnach
Banned
Tricky thing about placebos...sometimes they work. The human brain is a weird thing.
I think there's definitely synergy with other mitochondrial compounds, which I'm also taking...SLU, MOTS-C, 5 Amino, MB, Uniquinol/PQQ. But it was the addition of NAD+ subQ when the energy surge was noticeably different...brighter, cleaner, more pronounced lift in energy. As I'm just cycling through these compounds a couple months at a time I see it as low cost, high efficacy and harmless. But again it's different for everyone based on their age & physiology.
Stealth500
Member
actually in the article ghey went on to say the best way to take it was nmn sublingual.
I've tried that. Both NR & NMN...a variety of brands, and no noticeable effects. SubQ injections are cheaper and more effective for me.
Stealth500
Member
i didn't feel it in my mitochondria either...
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