Has anybody tried igf-1 for local growth?

[Proud Pangolin]

The question is basically in the titel? Has anybody tried it?

If so, what were tge results? What was your protocoll?

Woukd be nice if i coukd get specifically bigger side delta through this

 

[sionnach]

From the profile here on Meso:

a study done on young adult mice, a compound responsible for increased secretion of IGF-1 in muscle fibers was administered. There was an average increase of 15% in muscle mass and a 14% increase in strength. When the study was then conducted on adult mice, there was a 27% increase in strength in the injected muscles as compared with non-injected muscles.

It's still up to you to adjust your protein intake enough to let the IGF-1 do its job, and appropriately stress the target muscles, but yes, it appears you can target growth locally.

If I ever get around to trying the LR3 stash, I'll report back.

 

[Proud Pangolin]

From the profile here on Meso:



It's still up to you to adjust your protein intake enough to let the IGF-1 do its job, and appropriately stress the target muscles, but yes, it appears you can target growth locally.

If I ever get around to trying the LR3 stash, I'll report back.

I made a typo: i wa especially refering to igf-1 DES

 

[sionnach]

I made a typo: i wa especially refering to igf-1 DES

From what I understand, they all do the same things, but LR3 is roughly 2.5x more potent than IGF-1, and DES 10x. Start slow to watch for sides.

 

[Proud Pangolin]

Well why im interested in igf-1 DES is due to the short half life. (30min)

Igf-1 LR has a halflife of like 15h? So i guess thats why you get unwanted tissue growth, insuline resistance etc. from that.

The question is if that is enough for an anabolic effect.

 

[sionnach]

I would expect that would make it more site-specific than LR3. Keep in mind real IGF's half-life is only 10 min or so.

 

[Proud Pangolin]

I would expect that would make it more site-specific than LR3. Keep in mind real IGF's half-life is only 10 min or so.

True, butbin the other hand the bothe continous produces igf-1
( or why else would you have a more or less stable igf-1 bloodlevel)

 

[Ateam2023]

True, butbin the other hand the bothe continous produces igf-1
( or why else would you have a more or less stable igf-1 bloodlevel)

huh? Auto correct works wonders

 

[ItCantBe]

From what I understand, they all do the same things, but LR3 is roughly 2.5x more potent than IGF-1, and DES 10x. Start slow to watch for sides.

IGF1 DES has much more potent effect, ive seen the 10x number as well, but the half life is short <30 minutes so timing is critical. LR3 is system but there is some anecdotal reports of localized effect as well.

One thing to keep in mind, DES is often faked or sold vastly under dosed so vet your sources carefully.

 

[Proud Pangolin]

huh? Auto correct works wonders

Cant change the titel

 

[Proud Pangolin]

IGF1 DES has much more potent effect, ive seen the 10x number as well, but the half life is short <30 minutes so timing is critical. LR3 is system but there is some anecdotal reports of localized effect as well.

One thing to keep in mind, DES is often faked or sold vastly under dosed so vet your sources carefully.

Well what would be a good source? Because up till now i ordered from our chinese friends and i wasnt so concerned witg thing like Ipamorelin because its rarly faked etc. But now?

Also i really dont want to get IGF-1 LR somehow.

Any recommendations?

(Many sources have labresults but as these arent 3.Party that doesnt mean anything)

 

[sionnach]

Also i really dont want to get IGF-1 LR somehow.

Because you already tried LR3 and didn't like it?

 

[Proud Pangolin]

Because you already tried LR3 and didn't like it?

No because igf-1 LR3 goes systemic with a terribke long half live resulting in fast build up of insulin sensitivity and unwanted tissue growth.

That stuff is dangerous in my opinion.

With igf-1 DES you have a halflife of 20-30min so there isnt a big chance of it going systemic.

At the same time it has a over 10x stronger receptors affinity so in local tissue it should THEORETICALLY result in an significant anabolic effect despite its short halflife.

 

[sionnach]

I don't necessarily agree your fears about LR3 are worth that level of hysteria, but let's set that aside for now.

So why the obsession with DES if it's such a unicorn? Why not just use the ubiquitous, time-tested HGH?

(Remember source talk goes in the Source forum)

 

[eery]

The only thing ive heard from people is that they get a better pump for a few weeks with LR3. No actual tissue gains.

 

[Deadpool99]

Well why im interested in igf-1 DES is due to the short half life. (30min)

Igf-1 LR has a halflife of like 15h? So i guess thats why you get unwanted tissue growth, insuline resistance etc. from that.

The question is if that is enough for an anabolic effect.

To my knowledge. Clinically, IGF-1 LR3 improves insulin sensitivity rather than causing insulin resistance.

As human trials with recombinant IGF-1 consistently show lower fasting glucose, reduced hepatic glucose output, and greater peripheral glucose uptake. Hypoglycemia is the main risk, not hyperglycemia.

LR3’s long half-life means it stays active longer, maintaining that glucose-lowering, insulin-sensitizing effect for much of the day.

I never understood the “LR3 causes insulin resistance”. My plan is to actually use the lr3 to lower my AM fasted glucose while on HGH. I can't think of a way that lr3 would cause IR.

Also hypoglycemia is the documented risk in regards to IGF1, not hyperglycemia.

 

[Proud Pangolin]

I don't necessarily agree your fears about LR3 are worth that level of hysteria, but let's set that aside for now.

So why the obsession with DES if it's such a unicorn? Why not just use the ubiquitous, time-tested HGH?

(Remember source talk goes in the Source forum)

Its not about Igf-1 DES instead of GH. I think we all agree that GH is in anyway superior to igf-1 DES.

The question is about localized muscle growth. Lets say you have i dont know weak side delts. Can you overcome this weakness through injecting IGF-1 DES locally?

Because while systemic igf-1 wilk be more anabolic it wouldnt change the issue because that weakness remains.

Also igf-1 DES not going systemic would theoretically solve issues like unwanted tissues and organ growth. Basically for anabolism we only want igf-1 in our muscles nowhere else.

"If i would inject a shitton of igf-1 LR my organs woukd grow, i transform into a Neandertaler and get diabetes s well as very muscular. If i can inject a shittone on igf-1 DES into my sidedelts without it getting systemic i can build huge sidedelts without the other stuff"

So the question is: can it do this specific task and it not going systemic is needed for this.

 

[Ghoul]

Both have local and systemic effects. LR3 raises systemic levels more because of its longer half life while DES is cleared faster once it spills over out of the local area.

They've demonstrated localized, focused muscle growth in animals, and no real reason to believe it doesn't work the same in humans. It's just the simple mechanics of the compound hitting the receptors in the area it's injected.

Regular use of these actually raises acromegaly risks more than rHGH or the IGF-1 levels would suggest, because they are mostly immune to IGF binding protein, and especially LR3, stays highly active
for a long time. Usually IGFBP locks
up 99% of IGF, so only 1% is active, but not DES or LR3. You'd have to get free IGF levels tested (instead of just total) to get an accurate picture of IGF levels.

 

[Proud Pangolin]

Both have local and systemic effects. LR3 raises systemic levels more because of its longer half life while DES is cleared faster once it spills over out of the local area.

They've demonstrated localized, focused muscle growth in animals, and no real reason to believe it doesn't work the same in humans. It's just the simple mechanics of the compound hitting the receptors in the area it's injected.

Regular use of these actually raises acromegaly risks more than rHGH or the IGF-1 levels would suggest, because they are mostly immune to IGF binding protein, and especially LR3, stays highly active
for a long time. Usually IGFBP locks
up 99% of IGF, so only 1% is active, but not DES or LR3. You'd have to get free IGF levels tested (instead of just total) to get an accurate picture of IGF levels.

Hmm but what about the short halflife of 20-30min of IGF-1 DES?

The question is: is the short action in the target tissue enough for anabolism while its systemic effect isnt enough for acromegaly?

Because even with 20-30min half life it will go to some extend systemic. The question is how much? Is 20-30 min enough to transport it in the whole body?
To be honest i dont understand enough about how compounds get distributes in tge body.

Because when im injecting sq my GHRP-2 /CJC non dac wille experience the GH release after minutes. (Which i can tell because i get a bloodpressure rise ao this totally matches tge studys). After 30 the pulse is gone

Howver when injecting GH sq it takes like 1-2 h till peak serum levels are achieved.... which is really weird.....

 

[sionnach]

I don't think you're gonna get the answers you want until you try it bruh