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Weight Loss: Tirz or Reta for my case of NALFD

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ii337

New Member
27M, 170 cm, 70 kg, recently diagnosed with NAFLD.


Been on ~1,800 kcal/day and walking 20k+ steps daily for 2 months with minimal fat loss before I got diagnosed. Never used peptides before. I did some research to just boost this process up. (Goal is 7-8KG loss)

I’m considering a short-term protocol (around 12 weeks) with the goal of kickstarting fat loss and liver recovery, then maintaining the results through lifestyle change — not looking for long-term medication.

Question:
Would Tirzepatide or Retatrutide be more effective for this use case — moderate weight, NAFLD, short-term intervention for a permanent shift?

Any input is appreciated.
 
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My AI slop (Gemini):
At lower doses, as we just discussed, the glucagon agonism is likely less pronounced, and the effects are more akin to a strong GIP/GLP-1 dual agonist (like Tirzepatide). So, if someone is seeking a strong glucagon effect at these lower doses, they might indeed be "in for a rude shock."
* Higher Doses (e.g., 8mg, 12mg Retatrutide) for Full Triple Agonism:
* To get the full, pronounced benefits of the triple agonism, including the significant contribution from GCGR (e.g., for maximal energy expenditure, fat burning, and direct liver fat effects beyond what GLP-1/GIP alone provides), higher doses of Retatrutide (8mg, 12mg) are likely needed.

* Our "mg for mg" efficiency calculation for liver fat reduction highlighted this:
* Mazdutide 6mg (dual GLP-1/GCGR) delivered 80.2% liver fat reduction with 264 mg cumulative dose.
* Retatrutide 12mg (triple GIP/GLP-1/GCGR) delivered 86.0% liver fat reduction with 488 mg cumulative dose.

This means that to achieve comparable, high levels of liver fat reduction (where GCGR agonism is likely playing a significant role), Retatrutide requires roughly twice the total cumulative milligrams of drug compared to Mazdutide's effective dose for liver fat.
*End of AI slop*

My understanding of all this by looking at the recent data published is mazdutide works better at a lower dose for fatty liver. It also has less side effects.

Retatrutide needs significantly higher doses to fully saturate GIP then GLP1 and then finally GCCR.

It makes sense when you look at how each receptor works in the body.

Another cool tidbit for nature obsessed people:
"Mazdutide is an analogue of oxyntomodulin (OXM), a natural peptide hormone existing in humans that activates both GLP-1R and GCGR."
 
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To get back to the topic
Im gonna stack up on

Protocol:
• Week 1: 0.5 mg
• Week 3: 1.0 mg
• Week 5: 2.0 mg
• Week 7: 4.0 mg -> till Week 12

Essentials
Reta - 10mg * 10 Vials
Somatropin (rHGH) -15IU x 10 Vials
BAC Water 10ml x -10 Vials (contains benzyl alcohol)
Insulin Syringes
Alcohol Pads

Supplements
Electrolytes (Potassium, Sodium)
Omega 3
Vitamin D3K2

Tools
Track Injections with Shotsy
Track KCals MyFitnessPal

Plan:
Daily Diary
3x Resistance Training a week
2-3 Cardio Days a week
Monday Reta Injection SubQ Weekly
End of Day HGH Injection Daily other side of belly and rotate daily
Split up into 5 meals a day
Hit protein 2g/kg body weight
Dont forget fiber and electrolytes
2-3 litres daily
Sleep 8 hours

Anything you guys would do different or suggest? Thank you for the informative replies so far!
 
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ii337 said:
To get back to the topic
Im gonna stack up on

Protocol:
• Week 1: 0.5 mg
• Week 3: 1.0 mg
• Week 5: 2.0 mg
• Week 7: 4.0 mg -> till Week 12

Essentials
Reta - 10mg * 10 Vials
Somatropin (rHGH) -15IU x 10 Vials
BAC Water 10ml x -10 Vials (contains benzyl alcohol)
Insulin Syringes
Alcohol Pads

Supplements
Electrolytes (Potassium, Sodium)
Omega 3
Vitamin D3K2

Tools
Track Injections with Shotsy
Track KCals MyFitnessPal

Plan:
Daily Diary
3x Resistance Training a week
2-3 Cardio Days a week
Monday Reta Injection SubQ Weekly
End of Day HGH Injection Daily other side of belly and rotate daily
Split up into 5 meals a day
Hit protein 2g/kg body weight
Dont forget fiber and electrolytes
2-3 litres daily
Sleep 8 hours

Anything you guys would do different or suggest? Thank you for the informative replies so far!
Click to expand...
You do know the liver fat reduction seen on retatrutide was in OBESE people. You have a normal BMI.

Retatrutide won't do shit unless you get to the higher doses which is where the glucagon effects kick in.

But check back in and let us know. You're missing post prandial walks.
 
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bananafeet said:
You do know the liver fat reduction seen on retatrutide was in OBESE people. You have a normal BMI.

Retatrutide won't do shit unless you get to the higher doses which is where the glucagon effects kick in.

But check back in and let us know. You're missing post prandial walks.
Click to expand...
Depending on my tolerance week 7+ the dose can be adjusted
 
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Ghoul said:
That looks perfect. If you want to be very cautious you could start on 1iu rHGH the first week but given your age I doubt you'll have any issue on 2iu.

I wouldn't split the Reta dose up in this case, Once a week. All the data on GLP related NAFLD reversal is based on pharma protocols, and it may depend on hitting a high peak, rather than lower stable levels from split dosing. The bottom line is we know once a week works very well for NAFLD, even in lean people, but have no idea if split dosing is as effective.
Click to expand...
@Ghoul do you mean by rHGH Somatropin or other rHGH Fragments
 
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ii337 said:
Whenever Im looking for that - the most results I get is Somatropin. Like the actual name Somatropin. Most searches are also talking more about HGH missing the r. I was just trying to make sure. Thank you for the frequent answers and infos by the way. @Ghoul
Click to expand...

To be clear, rHGH, HGH, GH, Somatropin are all interchangeable.

The growth hormone "fragments" are attempts to sell a legal or less expensive form of rHGH, which isn't legal without a prescription in most countries. The real thing is so inexpensive now fragments make little sense.
 
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Im going to keep you updated here.
So I was weighing myself at my starting journey and measured everything and took my first jab yesterday.
Goals is to suport my NAFLD, reverse it and lose around 9-10% bodyfat

Starting
6th of August
68KG (peed in the morning)
84cm waist circumference
23,8% bodyfat

0.5mg Retatrutide

I felt that when I was eating my meal in the evening it felt a bit stuck in my stomache and made me fuller - might be placebo and will monitor over the next days.

I feel no side effects what so ever yet after 24 hours. Maybe I feel slightly warmer than usual but so far everything is the same basically. 1/10 very light nausea.

If it keeps going like this im considering to 1mg next week.
 
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After one week on Retatrutide and HGH, I feel...

mostly normal. I’ve had brief moments where I thought something had shifted, but overall not much change yet. I know the concentration should start taking effect in about four weeks. I might be experiencing slightly more fatigue, though I’ve also significantly increased my daily activity. My sleep quality has been very good lately - I wake up refreshed and fall asleep easily. This definitely improved and is not placebo.


Should I stay at 0.5 mg for another week and reassess, or increase to 1.0 mg now?
Tomorrow is my weekly weigh-in and body measurement.
 
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