Anyone tried the thrice weekly big bolus like this protocol recommends? Or have any opinions or disagree?
MESO-Rx
Anabolic Steroids
Anti-aging GH Protocol from Bolus
- Thread starter KOArtist
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I don’t believe he ever posted that one here, I can type it out when I get back to my book later though. It’s basically big Bolus thrice a week. The study did 7iu on MWF night only and it led to amazing fat loss and lean mass numbers.
Ghoul
Member
An interesting side note is the rHGH used from Eli Lily was 2.6iu/mg. A reminder that IU is a measure of activity (ability to increase IGF), and that 3iu per mg is an assumption based on perfectly manufactured rHGH, but never actually confirmed with any UGL product.
Purity does not equal activity.
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I'm not understanding this. The study says this for example "A recent double-blind, placebo-controlled study involving 27 women and 34 men, 68 to 88 years of age, who were given growth hormone or placebo for 6.5 months confirmed the effects of growth hormone on body composition; there was no change in muscle strength or maximal oxygen uptake during exercise in either group.<a href="https://www.nejm.org/doi/full/10.1056/nejmp020186#core-r003" data-xml-rid="r003">3</a> "
Then when I went to the source cited it says this ....
"Conclusions: Physiologic doses of growth hormone given for 6 months to healthy older men with well-preserved functional abilities increased lean tissue mass and decreased fat mass. Although body composition improved with growth hormone use, functional ability did not improve. Side effects occurred frequently."
It says body fat was lowered and muscle increased. But what you're saying is functionally its not making a difference so they don't count that as a net benefit?
Seems pretty straight forward to me. It increased LBM, reduced fat but did not affect strength or oxygen uptake. Don't look into what they said past that.
Ghoul
Member
That editorial was referring to a different study.
Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial - PubMed
In this study, GH with or without sex steroids in healthy, aged women and men increased LBM and decreased fat mass. Sex steroid + GH increased muscle strength marginally and VO( 2)max in men, but women had no significant change in strength or cardiovascular endurance. Because adverse effects...
pubmed.ncbi.nlm.nih.gov
NEJM and other "establishment" institutions are biased against anti-aging (vs fix shit after it goes wrong), and they actively opposite the use of rHGH for this purpose despite knowing it can provide benefits with minimal risks if used properly.
There's a philosophy of "Aging is not a disease" and "We must not pathologize aging", which is about as absurd and anti-science as the "Healthy obesity" and "Body acceptance" bullshit that infected medicine a few years ago.
That makes sense though. Nobody wants to tax payer fund this, so I can see why there is that spin on "anti-aging" anything.
It doesn't seem like adding hgh will make you live more years overall but it does seem like it'll make the years you live more enjoyable at small to moderate doses. You'll be a happier old person with more lean mass and less fat (assuming you're within normal ranges for all this).
Could you say anti-aging is the wrong word to use then, and instead say you'll have a better quality of life for a longer time? Higher lean body mass has many metabolic benefits that will keep you from getting sick later on in life.
It doesn't seem like adding hgh will make you live more years overall but it does seem like it'll make the years you live more enjoyable at small to moderate doses. You'll be a happier old person with more lean mass and less fat (assuming you're within normal ranges for all this).
Could you say anti-aging is the wrong word to use then, and instead say you'll have a better quality of life for a longer time? Higher lean body mass has many metabolic benefits that will keep you from getting sick later on in life.
Ghoul
Member
At physiological doses, generally 3iu and below:
On one hand we know
-increased lean body mass
-increased bone density
-reduced visceral fat (especially vital for men)
Are all clearly associated with longevity.
On the other, those with lower natural GH levels live longer as a group (though not necessarily "healthy years") and rHGH use is connected to greater cancer risk.
Personally I think with careful management. extra vigilance against cancer, rHGH may extend longevity, and certainly boost "quality of life" for the years remaining, which gives a person the will to live and motivation to take the steps necessary to ensure life goes on as long as possible vs "giving up" because life in a decrepit body ravaged by so called "normal aging" sucks.
Yeah, gotta love those body comp improvements, sounds healthy af to me
“The administration of human growth hormone for six months in group 1 was accompanied by an 8.8 percent increase in lean body mass, a 14.4 percent decrease in adipose-tissue mass, and a 1.6 percent increase in average lumbar vertebral bone density (P<0.05 in each instance). Skin thickness increased 7.1 percent (P = 0.07).”
“The administration of human growth hormone for six months in group 1 was accompanied by an 8.8 percent increase in lean body mass, a 14.4 percent decrease in adipose-tissue mass, and a 1.6 percent increase in average lumbar vertebral bone density (P<0.05 in each instance). Skin thickness increased 7.1 percent (P = 0.07).”
explodingHeart
Member
Now how much is that in QSC/Sigma Aldrich tier HGH?
Probably many other things, like Klotho and PF4 (figure from Blood platelet factor 4: the elixir of brain rejuvenation | Molecular Neurodegeneration), need to be restored in addition to growth and sex hormones to get significant, safe rejuvenation:
iow, returning to youthful HGH/IGF-1 levels may not be entirely safe without also fixing a bunch of other stuff. (At this point, we take just enough HGH to keep IGF-1 above 100 ng/ml, plus supplement sex hormones, at ages 70+.)
iow, returning to youthful HGH/IGF-1 levels may not be entirely safe without also fixing a bunch of other stuff. (At this point, we take just enough HGH to keep IGF-1 above 100 ng/ml, plus supplement sex hormones, at ages 70+.)
Ateam2023
Member
Quick search to get a " general" idea, excuse the ai ,
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Ateam2023
Member
how long have you been doing this m-w-f protocol? And have you noticed an effect on fbg? Or Rhr? , basically how long and any significant changes? Tia
songsofpyramids
Member
Also curious how it’s treating your RHR, HRV, and FBG. Looking to run this experiment for myself eventually.
Ateam2023
Member
i too was considering this 3x weekly dosing, but waiting for a few more reports from users doing this protocol,
That was the general gist I got out of ai too, but then watched some Kurt Havens video where they were absolutely convinced of the opposite.
