Hi all. Roast/rate my plan to tackle fatty liver.
Backstory: My liver enzymes were slightly elevated and my doc out of an abundance of caution ordered an ultrasound. My GGT was about 57, then I added injectable/liposomal glutathione and NAC and got it down to 43 then 21.6. But ALT (127.2, 54, 83.7) has remained high and AST slightly high (41, 40). I thought this was elevation was due to training. But the ultrasound showed a 4mm polyp on my gallbladder that needs monitoring to see if it grows and a slightly fatty liver. I'm 29 and about 10% BF and my HbA1c is 34.5 so the fatty liver was strange. I follow a clean diet without processed foods. I started test in January and have been conservative with my dosages (never more than 250mg/week with 100 primo). I fucked around with var at baby dosages of 5/10mg for about a month to upregulate collagen synthesis a little before climbing since it puts so much stress through the finger joints/tendons. And i'm on 10mg accutane/day. None of this seems enough to give me fatty liver in 3 months.
Nonetheless, I've dropped down to 140mg/week since the diagnosis while I come up with a plan of action.
I've been on 2mg of reta a week for about 2 months which I am thinking of upping the dosage since there is good evidence that it fights fatty liver. I am also on 3iu of HGH a night, NAC and glutathione. Citrus bergamot.
Supplements I am adding in: Tudca, Ox Bile, Sunflower lecithin in high doses (for phosphatidylcholine).
Going to up the cardio, adding in a couple sessions of HIIT a week.
My thesis is either there is some gut dysbiosis issue/ problem with gut-liver axis since I have been having digestion problems and fatty/runny stools around the time of diagnosis. Or it is related to my homozygous C677T MTHFR polymorphism that impairs my methylation capabilities which means my body, because it is so bad at using folate, preferentially utilises choline leading to a choline deficiency. My homocysteine wasn't out of range but came back high (around 14, when 7ish is ideal I believe). I got this idea from this peter attia podcast that discusses NAFLD (#46 - Chris Masterjohn, Ph.D.: Navigating the many pathways to health and disease - NAD and sirtuins, methylation, MTHFR and COMT, choline deficiency and NAFLD, TMAO, creatine and more - Peter Attia). Honestly a lot of this went over my head, so any insight from smarter folks would be greatly appreciated.
Going to have another ultrasound in 3 months or so and if this hasn't resolved itself I think the nuclear option is to go keto and then once fat-adapted do a water fast for 2-3days.
Questions:
Would tesamorelin be better than HGH purely from the perspective of fighting fatty liver? This study showed tesamorelin resolved NAFLD in 35% of HIV positive patients, but I don't know if this is independent of its fat-burning qualities/ its function of releasing HGH and therefore I should cut the middle man and just go to HGH?
Ideal dosage of reta to balance efficacy of shedding liver fat against nuking my appetite?
Does anyone have any experience with DADA to combat liver fat (study)?
Or PPC (polyenylphosphatidylcholine) a purified form of phosphatidylcholine which seems to have greater evidence in relation to NAFLD.
Any other supplements I should be looking at? Metformin, bempedoic acid, ezetimibe? Colostrum (for gut barrier, dysbiosis, but also evidence it decreases serum triglycerides/ ALT)
I am wary of doing too much too soon, so which are my biggest levers to pull here? (I am thinking reta, tudca and choline supplementation?)
Best cardio protocols/dietary interventions to fight liver fat?
Thanks for reading, bros.
Backstory: My liver enzymes were slightly elevated and my doc out of an abundance of caution ordered an ultrasound. My GGT was about 57, then I added injectable/liposomal glutathione and NAC and got it down to 43 then 21.6. But ALT (127.2, 54, 83.7) has remained high and AST slightly high (41, 40). I thought this was elevation was due to training. But the ultrasound showed a 4mm polyp on my gallbladder that needs monitoring to see if it grows and a slightly fatty liver. I'm 29 and about 10% BF and my HbA1c is 34.5 so the fatty liver was strange. I follow a clean diet without processed foods. I started test in January and have been conservative with my dosages (never more than 250mg/week with 100 primo). I fucked around with var at baby dosages of 5/10mg for about a month to upregulate collagen synthesis a little before climbing since it puts so much stress through the finger joints/tendons. And i'm on 10mg accutane/day. None of this seems enough to give me fatty liver in 3 months.
Nonetheless, I've dropped down to 140mg/week since the diagnosis while I come up with a plan of action.
I've been on 2mg of reta a week for about 2 months which I am thinking of upping the dosage since there is good evidence that it fights fatty liver. I am also on 3iu of HGH a night, NAC and glutathione. Citrus bergamot.
Supplements I am adding in: Tudca, Ox Bile, Sunflower lecithin in high doses (for phosphatidylcholine).
Going to up the cardio, adding in a couple sessions of HIIT a week.
My thesis is either there is some gut dysbiosis issue/ problem with gut-liver axis since I have been having digestion problems and fatty/runny stools around the time of diagnosis. Or it is related to my homozygous C677T MTHFR polymorphism that impairs my methylation capabilities which means my body, because it is so bad at using folate, preferentially utilises choline leading to a choline deficiency. My homocysteine wasn't out of range but came back high (around 14, when 7ish is ideal I believe). I got this idea from this peter attia podcast that discusses NAFLD (#46 - Chris Masterjohn, Ph.D.: Navigating the many pathways to health and disease - NAD and sirtuins, methylation, MTHFR and COMT, choline deficiency and NAFLD, TMAO, creatine and more - Peter Attia). Honestly a lot of this went over my head, so any insight from smarter folks would be greatly appreciated.
Going to have another ultrasound in 3 months or so and if this hasn't resolved itself I think the nuclear option is to go keto and then once fat-adapted do a water fast for 2-3days.
Questions:
Would tesamorelin be better than HGH purely from the perspective of fighting fatty liver? This study showed tesamorelin resolved NAFLD in 35% of HIV positive patients, but I don't know if this is independent of its fat-burning qualities/ its function of releasing HGH and therefore I should cut the middle man and just go to HGH?
Ideal dosage of reta to balance efficacy of shedding liver fat against nuking my appetite?
Does anyone have any experience with DADA to combat liver fat (study)?
Or PPC (polyenylphosphatidylcholine) a purified form of phosphatidylcholine which seems to have greater evidence in relation to NAFLD.
Any other supplements I should be looking at? Metformin, bempedoic acid, ezetimibe? Colostrum (for gut barrier, dysbiosis, but also evidence it decreases serum triglycerides/ ALT)
I am wary of doing too much too soon, so which are my biggest levers to pull here? (I am thinking reta, tudca and choline supplementation?)
Best cardio protocols/dietary interventions to fight liver fat?
Thanks for reading, bros.
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