MESO-Rx Sponsor STANFORD PHARMA PUBLIC SALE 10/24/21

[glpfun]

We should place bets on what the approved use for Reta will be. Really doubt it will be weight loss given the poor appetite control. Anecdotally I waste a lot of time in the vendor discords and I’ve noticed some very obvious trends about people’s choice in glp1. People who are overweight and focused on weight loss seem to pick tirz, people who are not overweight and have been training a long time seem to prefer Reta. Could be nothing, could be something. From my perspective Reta can get you the metabolic improvement and recompositioning without excessive weight loss. With tirz once I started to fix my nutrition and focus on high protein low fat meals it became difficult to eat enough clean calories everyday. I dropped my dose and I’m still like forcing food down when I’m not hungry just to get to 1500 calories.

 

[glpfun]

Losing weight is far too easy for me. I have to work to stay above 200lb at 6ft. Work as in I have no appetite ever. If I ate when hungry I would only eat 1 meal a day. Been like that since I can remember. But the health benefits sound interesting!! I just can’t be eating 1 meal every other day lmfao

This is why people who are already conditioned and at their ideal weight seem to prefer reta imo

 

[Ghoul]

Damn maybe I’ll try some of these GLPs. Which one is best for overall heart and artery health. Also is the appetite suppression something you can eat through. I have a hard time getting the calories in as it is.

Tirz (my recommendation) or Reta. Definately not Sema, Appetite suppression is too physically potent, while Tirz and Reta are primarily psychological appetite suppressors.

This is a case where you want to be able to use the highest possible dose that doesn't suppress appetite. It's not uncommon for men to go to 5 or 7.5 of Tirz without noticeable appetite suppression.

Tirz is much more economical for continuous use, but you should see similar benefits from either Tirz or Reta, whichever you choose.

It's also nice to have a pharma path.

Keep in mind if you're 27 BMI or higher with another condition like high blood pressure or sleep apnea, 70% of insurance policies will pay for Zepbound (tirz).

 

[glpfun]

Tirz (my recommendation) or Reta. Definately not Sema, Appetite suppression is too physically potent, while Tirz and Reta are primarily psychological appetite suppressors.

I’ve taken both tirz and Reta and the appetite suppression from tirz was overpowering compared to Reta. They are both agonists of glp1 but different intensities in my experience. I wouldn’t recommend tirz to anyone struggling with calorie intake.

 

[Ghoul]

I’ve taken both tirz and Reta and the appetite suppression from tirz was overpowering compared to Reta. They are both agonists of glp1 but different intensities in my experience. I wouldn’t recommend tirz to anyone struggling with calorie intake.

I know plenty who've felt nothing on Tirz all the way to 10mg, so there's a lot of individual variance.

Despite the studies showing much greater loss with Tirz, 2.4mg Sema brought me much lower than 15mg Tirz. I'm talking pharma for both.

GIP in both Tirz and Reta counteracts the nausea GLP induces when you eat beyond your appetite.. That's actually a very useful "stick" for rapid weight loss, but not useful when you're looking to maximize the other health benefits without appetite suppression.

 

[roofer22]

Damn maybe I’ll try some of these GLPs. Which one is best for overall heart and artery health. Also is the appetite suppression something you can eat through. I have a hard time getting the calories in as it is.

If you already struggle to eat I wouldn’t add any of those. Chances are it will make eating a chore you won’t want.

 

[DStevens]

Damn maybe I’ll try some of these GLPs. Which one is best for overall heart and artery health. Also is the appetite suppression something you can eat through. I have a hard time getting the calories in as it is.

I've tried both Tirz and Reta, much prefer Reta. It doesn't slow me down on food intake.
Microdosing is the way to go and great video by Jay Campell on it.

View: https://www.youtube.com/watch?v=fwuGsu5-xlg

 

[Ghoul]

Strongly advise against microdosing. Once a week works just fine. Protein therapeutics are not like other drugs where more frequent, lower doses just result in less variation of blood levels. It's much more complicated than that.

 

[glpfun]

I've tried both Tirz and Reta, much prefer Reta. It doesn't slow me down on food intake.
Microdosing is the way to go and great video by Jay Campell on it.

View: https://www.youtube.com/watch?v=fwuGsu5-xlg

How is micro dosing the way to go when there’s been no clinical studies on microdosing? Just going off of a celebrities “feels”? Sound advice lol

 

[DStevens]

How is micro dosing the way to go when there’s been no clinical studies on microdosing? Just going off of a celebrities “feels”? Sound advice lol

Did you even watch the video or simply swing a weak shot to make yourself sound good?

I've done the research on half-life info out there and verified my own information that consistent micro-dosing is the way to go. You have no idea of my own background or research that I've done on my own. There are a few sources of information out there, only linked the Jay Campbell video as they are pretty open with their own research and far from a celebrity and give out a ton if good information to base the start of some self-research.

But thank you for your useless opinion.

 

[glpfun]

Did you even watch the video or simply swing a weak shot to make yourself sound good?

I've done the research on half-life info out there and verified my own information that consistent micro-dosing is the way to go. You have no idea of my own background or research that I've done on my own. There are a few sources of information out there, only linked the Jay Campbell video as they are pretty open with their own research and far from a celebrity and give out a ton if good information to base the start of some self-research.

But thank you for your useless opinion.

Hey new guy, this is something that gets talked about literally every day here so good luck with your “you don’t know me” argument.

That’s you responding to my post ^

If you can’t explain exactly why it’s better you don’t understand yourself and are just going off of celebrity feels.

 

[Ghoul]

Did you even watch the video or simply swing a weak shot to make yourself sound good?

I've done the research on half-life info out there and verified my own information that consistent micro-dosing is the way to go. You have no idea of my own background or research that I've done on my own. There are a few sources of information out there, only linked the Jay Campbell video as they are pretty open with their own research and far from a celebrity and give out a ton if good information to base the start of some self-research.

But thank you for your useless opinion.

Do your research on immunogenicity and how frequency of administration of peptides can significantly alter that risk.

The question for the user is, does the benefit of introducing another risk factor, one with potentially serious long term consequences that can develop very slowly and go unnoticed, into a drug produced under sketchy, unregulated circumstances outweigh the benefit of this microdosing method that's undergone no clinical testing?

https://www.fda.gov/media/85017/download

Page 10.

 

[DStevens]

Do your research on immunogenicity and how frequency of administration of peptides can significantly alter that risk.

The question for the user is, does the benefit of introducing another risk factor, one with potentially serious long term consequences that can develop very slowly and go unnoticed, into a drug produced under sketchy, unregulated circumstances outweigh the benefit of this microdosing method that's undergone no clinical testing?

https://www.fda.gov/media/85017/download

Page 10.

Thank you for that link!

 

[DStevens]

Hey new guy, this is something that gets talked about literally every day here so good luck with your “you don’t know me” argument.
View attachment 316793
That’s you responding to my post ^

If you can’t explain exactly why it’s better you don’t understand yourself and are just going off of celebrity feels.

New guy that's been here longer than you. Yet again, click on something to do your own research instead of a headline. Enjoy your day!

 

[glpfun]

New guy that's been here longer than you. Yet again, click on something to do your own research instead of a headline. Enjoy your day!

Ok new guy, how you been here longer than me and not intimately familiar with Ghouls take on immunogenicity lmao

 

[hexagonal]

Strongly advise against microdosing. Once a week works just fine. Protein therapeutics are not like other drugs where more frequent, lower doses just result in less variation of blood levels. It's much more complicated than that.

I'm all for less pins, but one thing specific to reta keeps me doing it twice a week - once a week causes a much larger spike to my resting heart rate, which already runs high.

 

[chumpsickel]

I have been using Reta every 4 days and it continues to work for me. I tried once a week, but prefer every 4 days. Still getting lean at 2mg every 4 days. Just my real world experience.

 

[Ghoul]

I'm all for less pins, but one thing specific to reta keeps me doing it twice a week - once a week causes a much larger spike to my resting heart rate, which already runs high.

I try present info regarding potential risks that a lot of us (including me earlier on) never took into consideration.

We don't hear about immunogenicity because for pharma, it's dealt with long before the FDA allows the first human trial subject to be injected, years before it reaches the first patient, and is continually monitored once the drug is released to the public via "post marketing surveillance".

It's up to each one of us to make the risk/reward calculation.

Obviously, if I was completely risk averse i'd avoid UGL anything. Instead I try to minimize the odds of known risks, controlling factors I decide are worth the effort, even if those risks can't be quantified.

 

[hexagonal]

I try present info regarding potential risks that a lot of us (including me earlier on) never took into consideration.

We don't hear about immunogenicity because for pharma, it's dealt with long before the FDA allows the first human trial subject to be injected, years before it reaches the first patient, and is continually monitored once the drug is released to the public via "post marketing surveillance".

It's up to each one of us to make the risk/reward calculation.

Obviously, if I was completely risk averse i'd avoid UGL anything. Instead I try to minimize the odds of known risks, controlling factors I decide are worth the effort, even if those risks can't be quantified.

Certainly understandable (and appreciated.)

For me, weighing the risk of potential immunogenicity concerns over the long run vs. taking my heart rate to levels I am uncomfortable with leads me to the twice a week dosing being what I am more comfortable with. I'm about 3 months in, and I know in the studies that many people see the heart rate spike go away after 4-6 months, so I'll revisit once per week dosing if that occurs for me.

(Which isn't to say that I'm in favor of some self-proclaimed guru with a youtube channel's protocol of "microdosing" ed/eod)

 

[Ghoul]

Certainly understandable (and appreciated.)

For me, weighing the risk of potential immunogenicity concerns over the long run vs. taking my heart rate to levels I am uncomfortable with leads me to the twice a week dosing being what I am more comfortable with. I'm about 3 months in, and I know in the studies that many people see the heart rate spike go away after 4-6 months, so I'll revisit once per week dosing if that occurs for me.

(Which isn't to say that I'm in favor of some self-proclaimed guru with a youtube channel's protocol of "microdosing" ed/eod)

The increased heart rate is caused GLPs effect on the vagus nerve, which lowers heart rate variability. Something else in increasing your heart rate, GLP reduces the ability of the vagus nerve to push it back down.

The vagus nerve will compensate for this over time with more exposure to Sema/Tirz/Reta, so yes, if you switch back to once a week, you may notice it's not as bad as it was when you started.