Ghoul
Member
Well thanks for filling me in.
A gift from behind the paywalls...
2024 FDA Approved Excipients for Parenteral Peptide Formulations
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MESO-Rx
Anabolic Steroids
The Lobster International, AU, CANADA and EU Domestic HGH, PEPTIDES and Turkish Pharmacy
- Thread starter TheLobster
- Start date
Well thanks for filling me in.
A gift from behind the paywalls...
2024 FDA Approved Excipients for Parenteral Peptide Formulations
Spaceman Spiff
Subscriber
brutalbuilt
Member
you never had any bubbles appear at all after adding bac water?
every generic source i tried had bubbles form after adding bac water except serostim and lobster
Spaceman Spiff
Subscriber
I get it in serostim too. Depends on how fast water goes in there
Ghoul
Member
BD Nokor needles prevent foaming
Sprays onto sidewall while equalizing vial pressure with a vent.
Sprays onto sidewall while equalizing vial pressure with a vent.
Nice observation.
Formulation Factors Affecting the Formation of Visible-Bubbles During the Reconstitution Process of Freeze-Dried Etanercept Formulations: Protein Concentration, Stabilizers, and Surfactants - PubMed
Freeze drying is one of the common methods to extend the long-term stability of biologicals. Biological products in solid form have the advantages of convenient transportation and stable long-term storage. However, long reconstitution time and extensive visible bubbles are frequently generated...
pubmed.ncbi.nlm.nih.gov
"Under the same protein concentration, the formulation of mannitol mixed with sucrose in a weight ratio of 4:1 produces fewer visible bubbles during the reconstitution process compared to the formulation of sucrose with the same total mass. This has been proven to be due to the large number of smaller radius pores distributed in the pores of the freeze-dried cake of the former, while the average internal structure pores of the latter are much larger than those of the former. As an amorphous stabilizer, sucrose can ensure the long-term stability of protein and greatly reduce the generation and maintenance of foams in the reconstitution process, making it a more robust excipient for freeze-dried protein formulations."
Ghoul
Member
Nice observation.
Formulation Factors Affecting the Formation of Visible-Bubbles During the Reconstitution Process of Freeze-Dried Etanercept Formulations: Protein Concentration, Stabilizers, and Surfactants - PubMed
Freeze drying is one of the common methods to extend the long-term stability of biologicals. Biological products in solid form have the advantages of convenient transportation and stable long-term storage. However, long reconstitution time and extensive visible bubbles are frequently generated...
"Under the same protein concentration, the formulation of mannitol mixed with sucrose in a weight ratio of 4:1 produces fewer visible bubbles during the reconstitution process compared to the formulation of sucrose with the same total mass. This has been proven to be due to the large number of smaller radius pores distributed in the pores of the freeze-dried cake of the former, while the average internal structure pores of the latter are much larger than those of the former. As an amorphous stabilizer, sucrose can ensure the long-term stability of protein and greatly reduce the generation and maintenance of foams in the reconstitution process, making it a more robust excipient for freeze-dried protein formulations."
Crazy. The size of pores in the "cake" determine the propensity for bubble formation in lyophilized peptides.
So much effort put into this. Either all these guys hate bubbles or they might actually be significant in some way....
Very cool paper. Thank you for sharing. Related one I was reading.Bubbles and foam are terrible for peptides.
It causes a loss of active peptide and induces stronger immune reactions by inducing aggregation.
"the use of anti-foaming materials could prevent rhGH aggregation during bubbling"
Renewal of the air-water interface as a critical system parameter of protein stability: aggregation of the human growth hormone and its prevention by surface-active compounds - PubMed
Soluble proteins are often highly unstable under mixing conditions that involve dynamic contacting between the main liquid phase and a gas phase. The recombinant human growth hormone (rhGH) was recently shown to undergo aggregation into micrometer-sized solid particles composed of non-native...
The controversial role of isolated shear stress.
Slow and steady on the reconstitution. Bubbles/foam bad.
ExogenousDan
Member
Any idea when the 310 HGH will be in stock Lobster?
TheLobster
Subscriber
@TheLobster would it be possible to ship out 110 gh kits in plain white boxes instead of the lobster ones?
Thanks
Thanks
TheLobster
Subscriber
As mentioned in my post, if you order from the China International section on the website, you will receive all white boxes with blue caps
Thank you
Ateam2023
Member
im running qsc 15 iu kits at the moment and i've never had any foaming/bubbling problems,,,
TheLobster
Subscriber
If you know how to mix an HGH vial correctly, you won’t have bubbles or foaming. It’s all about using the right way. I believe he may not be doing it properly
Some customers insert the needle into the vial directly, allowing the vacuum to pull the water in too quickly, which can cause bubbles. If you are gentle and add the water slowly, there will be no bubbles or foaming
TheLobster
Subscriber
Hi everyone
HGH 310 IU and Retatrutide 10 mg are fully in stock
The products will be shipped for lab testing on Monday. I’ve opened them for sale, so if anyone is interested, you can check these products in the Lobster International section on the website.
Thank you
Also join our telegram channel please
In the Lobster International section, you can order all peptides either as a single vial or as a kit
HGH 310 IU and Retatrutide 10 mg are fully in stock
The products will be shipped for lab testing on Monday. I’ve opened them for sale, so if anyone is interested, you can check these products in the Lobster International section on the website.
Thank you
Code:
www.cartmangear.co/lobster-internationalAlso join our telegram channel please
Code:
https://t.me/+5qncO5C1LmU4MGJkIn the Lobster International section, you can order all peptides either as a single vial or as a kit
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HannibalSelector
New Member
Plz supply US domestic HCH
AlexDavis43
Member
It's either HGH or HCG...
BamaCrazy
Banned
It’s a new blend that gets you gainz and makes your nuggets grow.
TheLobster
Subscriber
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