Are you a fan of deca?Androgens and acid reflux, peptic ulcer
Learning about the gut histamine/androgen connection surprised me, so I thought I'd share what I learned about androgens and acid reflux and peptic ulcer, as it is not discussed often. If anyone has any useful information including anecdotes on what's worked for them with respect to AAS-induced...thinksteroids.com
Further, androgens are toxic. You might be using too high a dose as well.
MESO-Rx
Anabolic Steroids
Is trenbolone the only way to drastically increase IGF-1 sensitivity?
- Thread starter theoldmaster
- Start date
Type-IIx
Member
I can't say that I like it as I've never used it; and that makes it a bit odd since I've used virtually everything else (besides MENT) in multiplicity.
Some of the reasons for my not having used it include its effects on dopamine metabolism (increased dopamine breakdown, having effects on mood & libido that are generally unfavourable) & because it hangs around in your system for so long, in terms of a year or more, and I just think that that can't be good; it's not a massively unfavourable aspect to me, but a moderate one, and serves as a sort of "tie-breaker" when I'm matching it vs. some other AAS that I might be considering using.
What I do like about Deca is that it's aromatising (increasing IGF-I: so total body size) & potently muscle anabolic. Importantly, it benefits joints & connective tissues, so it really supports heavy loading & intensive training (but also by this same mechanism has some particular cardiac harms, i.e., due to ACE/MMP/procollagenous activity). Finally, I think we can all agree that there's a certain "Deca look," that's a "polished, 3D look" associated with full muscle glycogen stores & full muscle bellies... basically you look freakish quickly on Deca if you've got good size on you already, which is a major draw to it.
Androgens and acid reflux, peptic ulcer
Learning about the gut histamine/androgen connection surprised me, so I thought I'd share what I learned about androgens and acid reflux and peptic ulcer, as it is not discussed often. If anyone has any useful information including anecdotes on what's worked for them with respect to AAS-induced...
Further, androgens are toxic. You might be using too high a dose as well.
Isn't trenbolone's toxicity overstated? People will claim its more liver toxic than 17AA like Dianabol and Anadrol.
Type-IIx
Member
It's certainly being overstated, in fact it's just factually wrong, to claim that it's more liver toxic than Dianabol or Anadrol.
Strictly speaking, all androgens are toxic, including endogenous testosterone. That's why it has to be metabolized and excreted. To a significant degree (though not due to its inherent toxicity) testosterone is responsible for the sex-difference in mortality (men dying younger than women, largely due to cardiovascular disease, work accidents where the only reason that we're there is because of our larger size & strength, etc.)
Trenbolone does pose some risks to nephrons (the functional unit of the kidney) because AR activation induces "free radical stress" that estrogens protect against (and trenbolone is a potent nonaromatizable androgen), that much is true in theory.
K
klokke23
Guest
The same is true for MENT through the same mechanisms
Type-IIx
Member
I don't know that. Maybe baby.
K
klokke23
Guest
Okay idk. I tried at Cunninghams law lol
Wouldn't Telmisartan and staying hydrated help mitigate this kidney effect? - assuming you are not abusing the shit out of Tren?
@Type-IIx Curious about this as well.
But by "abusing the shit out of Tren", my main question would be would something like ~75-100mg of Tren Ace even be worth looking into? I know there are two opinions on this 1) Take a fuckton of it and you'll look amazing and anything less than 300mg is a waste 2) You really don't need that much to see some amazing benefits that will be comparative with a higher dose, without all the side effects.
boophomet
Member
My plan soon is to run 150mg Tren A per week, from what I've seen and read 100-200 will definitely have effects. There's definitely stronger effects at higher doses, but bigger side effects too. I can't remember the exact dosage off the top of my head, but the dose they give cattle for growth is surprisingly low, nowhere near the 500mg blasts people might run.
Type-IIx
Member
Honestly bro 100 mg weekly of trenbolone acetate is potent as fuck, and a lot of really strong and big guys don't use any more than that because of sides, but also because it's still so damn effective. For me, just 100 mg enanthate is too potent and intolerable these days. I used to run 700 mg acetate; not anymore, different life.
Would there be any prolactin sides at such dose?
Weren't most old school guys *only* using 1-2 amps of Parabolan a week anyway?
Curious as well, but I'm assuming this would be extremely individual and only reflected by bloodwork/side effects.
Type-IIx
Member
It'll probably still lower prolactin.
Tren still has plenty of sides at 100 mg/w! It's very individual, per-user. There are guys who tolerate it SO well at high doses and then there are guys that can't sleep for shit and think their girlfriend/wife is a cheating whore on 75 mg weekly.
Type-IIx
Member
That's right, 1 or 2 was very much a serious blast, 1.5 mL ampoules containing 76 mg of trenbolone hexahydrobenzylcarbonate (equivalent to approx. 50 mg weekly of trenbolone acetate) weekly was tremendous for top pros who used Parabolan.
This has been said repeatedly without any clear motive to lie, besides maybe the urge to act like you were more talented by getting more out of less, that I suppose can be influential given egos in bodybuilding. Say even triple it, seems reasonable right?
Say we triple it; it's still way lower than the commonly recommended initiation of 350 mg weekly today.
Please give some more info. Short googling says Tren/Nand actually lowers prolactin instead of increasing it. What the fuck?
Type-IIx
Member
That's correct, nonaromatizable androgens (e.g., Tren, Mast [drostanolone]) lower prolactin rather than increase it.
Aromatizable androgens (e.g., Test, Nand, MENT), including nandrolone, tend to lower it when estrogens are sub-normal/low-normal but can increase it when estrogens run moderately-high/high.
Here's some more info:
Article on distinguishing progestins, prolactin, and progestagenic androgens (e.g., Tren, MENT, Deca) & SERM vs. AI logic [by Type-IIx] – with special emphasis on the "Anabolic steroids increase serum prolactin" section.
De Las Heras, F., & Negro-vilar, A. (1979). Effect of Aromatizable Androgens and Estradiol on Prolactin Secretion in Prepuberal Male Rats. Archives of Andrology, 2(2), 135–139. doi:10.3109/01485017908987305
Van Der Gugten, A. A. (1971). The effect of 1-(morpholinomethyl)-4-phtalimido-piperidindione-2,6 and drostanolone propionate on the plasma prolactin concentration of oestrone-treated orchidectomized R-Amsterdam rats. European Journal of Cancer (1965), 7(6), 581–582. doi:10.1016/0014-2964(71)90066-1
Sodi, R., Fikri, R., Diver, M., Ranganath, L., & Vora, J. (2005). Testosterone replacement-induced hyperprolactinaemia: case report and review of the literature. Annals of Clinical Biochemistry, 42(2), 153–159. doi:10.1258/0004563053492784
Segaloff, A., Weeth, J. B., Cuningham, M., & Meyer, K. K. (1964). Hormonal therapy in cancer of the breast.XXIII. Effect of 7α-methyl-19-nortestosterone acetate and testosterone propionate on clinical course and hormonal excretion. Cancer, 17(10), 1248–1253. doi:10.1002/1097-0142(196410)17:10<1248::aid-cncr2820171005>3.0.co;2-a
Alexis sarridi
New Member
Can you really believe that this guys had access to pharmacy and after a while high on androgens compete each other who is better and kept their use low?Maybe at start and few guys but most abused it.I think most just didn't pct or stay on trt dose or any other knowledge we have today and they just went by basics and feeling like I think you mean but they abused them for sure,just more strange ups and downs,full on full off without knowing what to use,not everybody but many.I wonder if they used prescription amphetamine regular
What the fuck are you talking about?
Alexis sarridi
New Member
Nothing Princess,I am not talking directly to you because there is also two other people expressing opinions.Now if I manage to make you understand I mean could a dopamine agonist from pharmacy like prescription amphetamine or something else help with the prolactin?I don't know what was available back then so I was just speculating,did you understand now that I am answering directly to you what the fuck I am talking about? Don't get too angry when you reply the androgens plus the attitude increase your blood pressure and it is not good for your health
Similar threads
