Anxiety Medications. What has worked for you?

Fellas, you have to tone it down with voicing your opinions in such a manner; "those people are stupid", "This whole long acting benzo withdrawal is retarded and wrong.".

The issue with BZD's withdrawal is a well known and studied medical phenomena. Nobody on this forum is going to outsmart decades of clinical practice of psychiatrists and researchers dealing with this issue no matter how strongly or bluntly you voice your opinion.

The issue of long HL BZD's vs short HL BZD's is well characterized and it mostly pertains to whitdrawal/rebound anxiety which is due to much quicker onset, harder to control with shorter HL BZD's. Moreover, some BZD's have a higher response in dopamine transmission elevation. Alprazolam for instance, can be notably dopaminergic for some people, while clonazepam will hardly ever have present with such pharmacodynamics.

Most lay persons when they use for instance xanax, have a much higher chance of quickly redosing when the rebound anxiety happens. People have busy life's and aren't too focused on what's going on in their head, and when the rebound anxiety happens, redosing can be instinctual, and often is.

The other issue is the aformentioned accompanying dopamine response. If there is a very small time window between ingestion of a compound and a subsequent dopamine response, the said compound will have a much higher addiction profile. This is precisely the reason why coke is so addicting when insulfated but not nearly as much when taken per-os. The phenomena described is dopamine's habituating nature. It's pretty simple: whatever you're doing when the large dopamine release happens, you become habituated to that action. In the case of a quick onset dopaminergic drug, one simply becomes habituated to the action of taking the drug. But if dopamine release happen an hour later, the brain doesn't put the two and two together and you become habituated to whatever you're doing when the "dopamine hits". This is how you get accustomed to things you're too lazy to be doing, like studying for instance: you start studying, you take your stimulant and 45m later when it hits and you're still studying, simply put, your brain remembers pleasure = studying.

It is very much true that there is great variability in individual response to BZD withdrawal (physical symptoms and anxiety levels) but this has nothing to do with the users "stupidity" and much to do with individual neurobiology/biology. Clonazepam is one of the BZD's with the cleanest withdrawal profile and is also often used to help patients wean off of alprazolam or some other shorter acting BZD's. If one is so inclined to use BZD's, it's one of the safest options and is basically the only thing I agree with in the above posts.

@readalot I'm interested in hearing more about your story of ssri's and then ending on using clonazepam 3 x a week. What was your experience with using the ssri? Have you achieved relief?
The dopamine is the key. When our brain experiences something pleasurable it gets "bookmarked" as pleasurable by the release of dopamine from the midbrain to the pre frontal cortex. When it is better than expected the pre frontal cortex sends glutamate back to the midbrain which commits this to memory. This is the process by which addiction is formed and the mid brain (survival or reptilian brain) hijacks the prefrontal (decision making) brain. Your brain makes associations between what you were doing when the pleasure center was activated, and as a result you also receive chemical cues to want to repeat a behavior. Then there is the stress hormone feedback loop. Your body releases a stress hormone in response to a dopamine release which is why we can relieve stress by working out. When you constantly spike a dopamine release (by taking a substance) in response to a stressor, your body responds by adjusting the threshold at which the stress hormone is released. It takes more and more dopamine to achieve the same result. Which means it will take more and more of the substance. A habit being formed is not psychological but rather physiological because of this process. Depending on contributing factors such as genetic predisposition It may take years, it may happen very quickly, or not at all, but you are gambling with something very dangerous when you use any addictive substance.
 
I'm not going to get dragged into an internet argument over this, i've nothing to gain from it whatsoever - I already know from experience what pyrazolam can do, and what it doesn't. I thought my input might help someone suffering from anxiety, and that mentioning what I found extremely helpful could give them a start point to do their own research. Anyhow, seeing as I have 5 minutes, here's a couple of 'science' links people can look at, or not - makes no difference to me tbh, I only dip in and out of this forum now and again. I'm sure there's plenty more, there's definitely many user experiences. And keep in mind, you don't ALWAYS need a pubmed article to know that something works (ie, AAS's plus resistance exercise can increase muscle size and strength - would you trust user experience for that, or would you wait for a pubmed article showing what a gram of test / tren/ deca does?)

Quote - "Pyrazolam is most selective for the α2 and α3 receptor subtypes"


Quote - "Recently, the addictive properties of BDZs have been shown to require the α1-containing GABAARs"


Quote - "Recent findings have highlighted the importance of α1 containing GABAA receptors in the mechanisms of addiction and tolerance in benzodiazepine treatments. This has shown promise in the development of tranquilizers with minimal side effects such as cognitive impairment, dependence, and tolerance".
Happy customers (NON SCIENTIFIC EXPERIENCES, SORRY)

Interesting. This is still sold as an RC on the clearnet.

The only BZD that I use, and that's strictly for ADHD productivity purposes is Tofisopam. It's not a standard BZD as it's molecular structure is different. It's a 2,3-benzodiazepine, so it isn't sedating, same as pyrazolam. But besides that, it's a PDE10 inhibitor, which means: increased dopamine production. I find it very helpful for work.
 
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Interesting. This is still sold as an RC on the clearnet.

The only BZD that I use, and that's strictly for ADHD productivity purposes is Tofisopam. It's not a standard BZD as it's molecular structure is different. It's a 2,3-benzodiazepine, so it isn't sedating, same as pyrazolam. But besides that, it's a PDE10 inhibitor, which means: increased dopamine production. I find it very helpful for work.
Interesting. I have a bunch of Tofisopam but I've never tried it. I kind of don't want to rock the boat and change my brain chemistry too much right now, but the dopamine effect sounds interesting. Can you elaborate more?
 
Not to derail the debate here but when I mentioned my Ritalin bieng the most helpful drug, I didn’t mention the years of therapy bieng actually more helpful. I know this is a drug thread and drug forum but the combination was life changing for me and it sounds like many others have other life changing experiences here.

Im assuming to get scripts many on this thread are also invested in mental health with therapy bieng it’s anchor? I only mention this because I feel like that aspect may be getting missed or downplayed? I know in our society it can be taboo as a big strong guy to talk about feels but it sounds like we are all tossing our shit on the table? Am I’m off base here?
 
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Interesting. I have a bunch of Tofisopam but I've never tried it. I kind of don't want to rock the boat and change my brain chemistry too much right now, but the dopamine effect sounds interesting. Can you elaborate more?

It's via pde10 inhibition which (generally) increases intracellular cAMP which then increases PKA. PKA can then phosphorylate various targets, including dopamine receptors. Meaning, dopamine receptors can get supersensitized.

The other way is by modulating gabaergic interneurons which modulate dopamine. If you inhibit these neurons it can lead to a reduced inhibitory tone of dopaminergic neurons which can enhance the release of dopamine.

Tofisopam is mild, so you might not notice it at lower dosages. I'm ADHD-PI and have very low tonic dopamine levels and thus, I notice any dopamine elevation.

On a nother note, Tofisopam doesn't actually interact with the gaba receptor.
 
The best benzo for this is clonazepam/klonopin but only at low doses (best is .25-.50mg occasionally or daily. Maybe 1mg here or there.) and only certain brands. For example, the Teva brand is the only one that works properly. The Teva one is pure clarity. Other brands make people depressed, angry, hungover, intoxicated, terrible etc. I don't know why that is, but the difference is so strong that it should make everyone cautious about even using these medications due to the unpredictability in formulations and the different supply availabilities.

If you get on a bad brand of clonazepam and use the wrong dosages, it can turn you into a different person and it can really hurt your life. The good brand at the good dosage......can enhance your life.

But I recommend everyone avoid taking these medications if they don't have too. It's good to have some on hand just in case you may feel you need it, but overall, there are better ways.

And SSRI's like Lexapro work amazingly well for anxiety and should be tried, temporarily, but those medications are dangerous too. I wouldn't take them for very long.
Completely agree. I'm on .25mg of clonazepam as needed up to twice a day. A game changer for me concerning my anxiety.
 
I saw a couple mentions for Effexor. That's a no go for me. Horrible sexual side effects. I'm glad this thread is helping so many.
 
You should read this link: Klonopin: Protecting the Brain

Clonazepam protects the brain.

Brother, basically everything that lowers excitatory neurotransmission, in which category gaba agonists like BZD's definitely fall in to, will help "protect the brain". But saying clonazepam is "protective for the brain" from this point of view is really misleading for the non educated reader and it's implying clonazepam is somehow healthy to take.

If we are talking about glutamate excitotoxicity, long term the drugs used for that are/should primarily be NMDAr competitive antagonists and a bit more serious noncompetitive antagonists.

If there is an overabundance of glutamate you definitely don't go taking BZD's for it. That makes little sence and isn't medical practice. Even in rare instances of glutamate storm BZD's aren't used but agents like calcium chanel blockers, NMDAr and AMPA antagonists and antiepileptics are used.
 
I just started on ketamine and it’s been a quick disappointment. I’ll have to give it a longer try but so far ☹️. But they say it’s supposed to be great so maybe it’s just me.
 
Not really related to anxiety but does anyone know if chronic AAS use (including tren) can cause anhedonia and numbness/loss of joy? I'm guessing it's low seratonin. No issues with getting work done. In fact that's all that I do and what keeps me going - getting shit done. It does not result in any happiness though.
 
If we are talking about glutamate excitotoxicity, long term the drugs used for that are/should primarily be NMDAr competitive antagonists and a bit more serious noncompetitive antagonists.

Maybe memantine or agmatine could help there then. I've used both, and found both to help a fair bit with stress / tension. Agmatine's also good as a 'pump' type supplement, so good for workouts, and if i remember right, mementine can have a positive effect on dopamine.
 
Not really related to anxiety but does anyone know if chronic AAS use (including tren) can cause anhedonia and numbness/loss of joy? I'm guessing it's low seratonin. No issues with getting work done. In fact that's all that I do and what keeps me going - getting shit done. It does not result in any happiness though.
Yeah tren drags me down mentally after about 8-9 weeks and gives noticeable anhedonia if I keep going on it.

BPC157 gives it to me within a couple days but it’s so amazing at healing I just suffer through it if needed.
 
I had to go off Brother. Fortunately the panic seems to be gone after a year on the med even off the med but it is still early. The brain zaps are nuts (been off 3 weeks).

Took my Test up to 200 mg/week and planning a nice little blast. That should make things interesting.

But yes a few weeks off the lexapro and the anhedonia is better. Best wishes!
I was on citalipram a few years and I got those zaps too. That’s why I got off them it freaked me out lol but my anxiety/ panic did get better
 
Maybe memantine or agmatine could help there then. I've used both, and found both to help a fair bit with stress / tension. Agmatine's also good as a 'pump' type supplement, so good for workouts, and if i remember right, mementine can have a positive effect on dopamine.

For sure. Memantine is used exactly for this reason in dementia. Regarding dopamine; it's a D2 agonist. but those receptors desensitize rather quickly so not much point to that really. However, nmda antagonist's do modulate addiction and they can help re-sensitize dopamine receptors, which is another reason why people use it; to help stimulant tolerance. Agmantine is also a popular nootropic.
 
For sure. Memantine is used exactly for this reason in dementia. Regarding dopamine; it's a D2 agonist. but those receptors desensitize rather quickly so not much point to that really. However, nmda antagonist's do modulate addiction and they can help re-sensitize dopamine receptors, which is another reason why people use it; to help stimulant tolerance. Agmantine is also a popular nootropic.

Yes, when i've used memantine in the past (to assist with kratom tolerance), the d2 stimulation was a nice bonus, but as you said doesn't last long. I prefer agmatine.
 
Selank 300-900mcg a day pinned works wonders for me, its like Xanax without the buzz, no high, just relief from stress and worry, it takes a few days to start working
 
Back in rehab like 9 years ago they prescribed everyone buspar. It was up to you if you wanted to take it or not.

It wasn’t the typical rehab resort place.

Mostly felons and people being released from prison on parole needing to go to this rehab place in order to get out of prison early . It was basically county jail disguised as a rehab facility

I opted to not take it but my bunkie took it and said it helped him.
 
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