Wuhan Wansheng Biotechnology Co., Ltd. (USA, International)

just got my package and got 1 out of 2 bu300 oxidized with dark yellow color and 2 out of 4 test u 300 crystalized, what to i throw?
 

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True! Still dimer is to high on both!

Dimer is the least important quality marker imo. Purity, quantity, then dimer.

You could have 0% dimer and a vial that goes cloudy because it only forms giant aggregates, instead of the smallest type (dimer, ie, two monomers).

Aggregates don’t have to follow a path of growth like two monomers getting stuck into a dimer, then trimer, oligomer etc.

During reconstitution, damaged (heat or oxygen exposure) rHGH can go from Zero monomer aggregated straight to ten million lumping up together into each aggregate, forming visible particles in an instant, and still test Zero dimer because those get filtered out prior to testing.

Meanwhile a high quality formulation could have a small amount of stable dimer, and not create any further aggregates.

In any case, it’s another huge red flag for all of the 3 letter resellers, WWB, GGB, HYB. They should’ve tested prior to selling anything, or at least say “this batch hasn’t been tested yet”. They all failed at that.

And now that you know who is back, I’m not sure any sensible buyer will risk it with any of those guys again. There was a small window of opportunity for one of them to become the next SSA/QSC, but I don’t see that happening now. They all got drunk and sloppy on the huge influx of sales after SSAs collapse.
 
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Dimer is the least important quality marker imo. Purity, quantity, then dimer.

You could have 0% dimer and a vial that goes cloudy because it only forms giant aggregates, instead of the smallest type (dimer, ie, two monomers).

Aggregates don’t have to follow a path of growth like two monomers getting stuck into a dimer, then trimer, oligomer etc.

During reconstitution, damaged (heat or oxygen exposure) rHGH can go from Zero monomer aggregated straight to ten million lumping up together into each aggregate, forming visible particles in an instant, and still test Zero dimer because those get filtered out prior to testing.

Meanwhile a high quality formulation could have a small amount of stable dimer, and not create any further aggregates.

In any case, it’s another huge red flag for all of the 3 letter resellers, WWB, GGB, HYB. They should’ve tested prior to selling anything, or at least say “this batch hasn’t been tested yet”. They all failed at that.

And now that you know who is back, I’m not sure any sensible buyer will risk it with any of those guys again. There was a small window of opportunity for one of them to become the next SSA/QSC, but I don’t see that happening now. They all got drunk and sloppy on the huge influx of sales after SSAs collapse.
Someone said: to high dimer (above 0.4) can make you immune to GH and it will never work again!?
 
There are at least 3 batches of yellow tops. Silver sticker, white sticker, both with “flip off text on cap” and one “smooth top” cap.

Test notes “pics attached” but they’re not.
Exactly, I have the silver version with flip-off cap text, same for the green 12 IU vials.
I've been pinning the green caps for 2 weeks at only 1 IU and I'm already feeling numbness and tingling.
Unfortunately, it's not precise and i don't know if I'm under or over-dosing :confused:
I'll likely send a vial to Jano to get it tested
 
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Someone said: to high dimer (above 0.4) can make you immune to GH and it will never work again!?

No, immunogenicity only happens when aggregates are in the same size range as a bacteria or virus body.

0.1 um to 100 um, although the most likely to cause immunity are 0.5um to 10 um.

rHGH dimer is only 0.006um, almost 1000x too small to cause the problem.

.22um filtering removes 99.9% of the aggregates that could cause immunogenicity.
 
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