Why dont we have dual GIP and GCGR agonists?

[Proud Pangolin]

So i do understand that most of the fatloss from well Reta comes from the appetite surpression through the GLP-1 action (like with Sema and Tirz).

However the real "fatloss" /"fatburning" effect meaning lipolysis comes from the Glucagon action (GCGR) and also higher Insulinsensitivity (GIP)

So why arent we seeing GCGR + GIP agonists?

Would that be very interesting form "us" as a fatburner that we can take for a long time with rather minimal sides compared to other fatburners like Clen? Basically like the fatburning effect of GH.

Or is exactly the problem that its only for us interesting and for obese people this simply wont result in enough fatloss?

Or what am i missing here?

 

[Ghoul]

So i do understand that most of the fatloss from well Reta comes from the appetite surpression through the GLP-1 action (like with Sema and Tirz).

However the real "fatloss" /"fatburning" effect meaning lipolysis comes from the Glucagon action (GCGR) and also higher Insulinsensitivity (GIP)

So why arent we seeing GCGR + GIP agonists?

Would that be very interesting form "us" as a fatburner that we can take for a long time with rather minimal sides compared to other fatburners like Clen? Basically like the fatburning effect of GH.

Or is exactly the problem that its only for us interesting and for obese people this simply wont result in enough fatloss?

Or what am i missing here?

GIP alone promotes body recomposition... in the wrong direction. Encourages fat storage. Also boosts glucagon release, so the liver synthesizes more glucose than normal, blood sugar rises, increasing insulin resistance and the risk of developing diabetes.

Glucagon alone boosts blood sugar, speeds up heart metabolism (not in a good way). It's actually the most potentially harmful of the three hormones and numerous drugs with glucagon agonism failed trials because of harm to health. The balance of GLP/GIP with glucagon seems critical to maintain safety and Reta should probably not be stacked with other GLPs, especially long term.

GLP agonism triggers fat lipolysis, much more strongly than GIP promotes storage. In fact it completely overrides it. In this GLP "always release don't store" fat cell state, what remains of GIPs influence on fat cells actually BOOSTS lipolysis even more than GLP alone. It's like GIP opens a door intended to allow the fat cells to take in fat for storage, but GLP is so much more powerful fat gets sent out through that "in" door once GIP opens it, speeding up lipolysis even more than GLP alone.

 

[dinfar1337]

The balance of GLP/GIP with glucagon seems critical to maintain safety and Reta should probably not be stacked with other GLPs, especially long term.

i fucking cant wait for the phase 3 trials.

they better do us right and answer all our questions.

 

[Proud Pangolin]

GIP alone promotes body recomposition... in the wrong direction. Encourages fat storage. Also boosts glucagon release, so the liver synthesizes more glucose than normal, blood sugar rises, increasing insulin resistance and the risk of developing diabetes.

Glucagon alone boosts blood sugar, speeds up heart metabolism (not in a good way). It's actually the most potentially harmful of the three hormones and numerous drugs with glucagon agonism failed trials because of harm to health. The balance of GLP/GIP with glucagon seems critical to maintain safety and Reta should probably not be stacked with other GLPs, especially long term.

GLP agonism triggers fat lipolysis, much more strongly than GIP promotes storage. In fact it completely overrides it. In this GLP "always release don't store" fat cell state, what remains of GIPs influence on fat cells actually BOOSTS lipolysis even more than GLP alone. It's like GIP opens a door intended to allow the fat cells to take in fat for storage, but GLP is so much more powerful fat gets sent out through that "in" door once GIP opens it, speeding up lipolysis even more than GLP alone.

Thanks, i realised that i got a lot of things wrong with this.

 

[anon55]

GIP alone promotes body recomposition... in the wrong direction. Encourages fat storage. Also boosts glucagon release, so the liver synthesizes more glucose than normal, blood sugar rises, increasing insulin resistance and the risk of developing diabetes.

Glucagon alone boosts blood sugar, speeds up heart metabolism (not in a good way). It's actually the most potentially harmful of the three hormones and numerous drugs with glucagon agonism failed trials because of harm to health. The balance of GLP/GIP with glucagon seems critical to maintain safety and Reta should probably not be stacked with other GLPs, especially long term.

GLP agonism triggers fat lipolysis, much more strongly than GIP promotes storage. In fact it completely overrides it. In this GLP "always release don't store" fat cell state, what remains of GIPs influence on fat cells actually BOOSTS lipolysis even more than GLP alone. It's like GIP opens a door intended to allow the fat cells to take in fat for storage, but GLP is so much more powerful fat gets sent out through that "in" door once GIP opens it, speeding up lipolysis even more than GLP alone.

This might be a stupid question, but is using a small dose of reta (1 or 2mg) to not get any appetite suppression in a bulk a good or bad idea?
At this dose the GIP agonism is super active compared to GLP1 and glucagon, meaning more fat gain?

 

[Proud Pangolin]

This might be a stupid question, but is using a small dose of reta (1 or 2mg) to not get any appetite suppression in a bulk a good or bad idea?
At this dose the GIP agonism is super active compared to GLP1 and glucagon, meaning more fat gain?

I would be interested in this as well because i for example cant use Reat om a diet. Im getting hypoglycemia at night which results in insomnia
(waking up acouple hours after falling asleep and then not beeing able to fall asleep again and if wake up every hour and roll around in bed. Really even worse than insomnia from high E2)

However during a Bulk where i have enough carbs in the systems i hope this shouldnt be a problem

 

[songsofpyramids]

This might be a stupid question, but is using a small dose of reta (1 or 2mg) to not get any appetite suppression in a bulk a good or bad idea?

There are lots of positive anecdotal reports on here of people using Reta on a bulk. Thus far the phase 3 trials of Reta have reported tons of positive impact as well. I personally find incredible health benefits from low dose sema both cutting and bulking. It has improved my blood work drastically and even reduced my tinnitus.

 

[BlackVeil]

There are lots of positive anecdotal reports on here of people using Reta on a bulk. Thus far the phase 3 trials of Reta have reported tons of positive impact as well. I personally find incredible health benefits from low dose sema both cutting and bulking. It has improved my blood work drastically and even reduced my tinnitus.

Theres a massive dude on PM, in the reta thread using reta on his bulk.
Dude is 305lb or something and his profile pic looks insane.
His positive reports have made me want to try it once I am done cutting.

 

[BlackVeil]

 

[songsofpyramids]

View attachment 356981

Holy shit that dude is a literal monster. Pretty serious endorsement for glp1 right there. PM has a ton of people reporting positives from Reta. I think glp1 is one of the most beneficial things you can take for bodybuilding or just for your health in general. Goes double if you’re doing hgh or anything else fucking with blood glucose. If you have any crp issues whatsoever I’d go so far as to say glp1 is the first tool in the box I’d grab.

 

[professionaldyel]

This might be a stupid question, but is using a small dose of reta (1 or 2mg) to not get any appetite suppression in a bulk a good or bad idea?
At this dose the GIP agonism is super active compared to GLP1 and glucagon, meaning more fat gain?

If you live the actual bodybuilder lifestyle there really isnt a point to use low dose reta for the health benefits.

10k steps ED with 15 minute walks after meals
25 minutes cardio 5x/wk 130-140bpm
Minimal main dietary fat - trace fats are whatever ie eating 88/12 ground beef
Moderate fiber intake
Carb cycling high/medium/low days

Lipids go down, insulin sensitivity goes up, and body composition improves which is all you're really chasing after in the end.

 

[songsofpyramids]

If you live the actual bodybuilder lifestyle there really isnt a point to use low dose reta for the health benefits.

That’s just simply not true.

Glp1 is expected to become a front line treatment for heart failure because it is so cardio protective, and that is good for everyone especially people doing the shit bodybuilders are. Glp1 are being tested as preventatives for Alzheimer’s, neural protection is good for everyone. Glp1 is being looked into as a frontline treatment for autoimmune conditions because it’s so effective at lowering inflammation and crp, another big bodybuilding issue. I have tinnitus associated with ptsd and glp1’s have reduced my symptoms night and day. There are a host of benefits already known about glp1 drugs and more studies showing new and different benefits every day. My bloodwork increased across the board from low dose sema and I have always strived to live an athletic lifestyle.

Living and active healthy lifestyle is incredibly important, no lie there. Fading grip strength is one of the leading predictors of declining health that exists. All of what you said is great for health and longevity. Glp1 is another layer of protection you can add on top of it. Plus the synergy with hgh is just out of this world even with lower doses of glp1.

 

[professionaldyel]

That’s just simply not true.

Glp1 is expected to become a front line treatment for heart failure because it is so cardio protective, and that is good for everyone especially people doing the shit bodybuilders are. Glp1 are being tested as preventatives for Alzheimer’s, neural protection is good for everyone. Glp1 is being looked into as a frontline treatment for autoimmune conditions because it’s so effective at lowering inflammation and crp, another big bodybuilding issue. I have tinnitus associated with ptsd and glp1’s have reduced my symptoms night and day. There are a host of benefits already known about glp1 drugs and more studies showing new and different benefits every day. My bloodwork increased across the board from low dose sema and I have always strived to live an athletic lifestyle.

Living and active healthy lifestyle is incredibly important, no lie there. Fading grip strength is one of the leading predictors of declining health that exists. All of what you said is great for health and longevity. Glp1 is another layer of protection you can add on top of it. Plus the synergy with hgh is just out of this world even with lower doses of glp1.

Youre typing emotional non sense like most PEDs do brother. The entire point of using Retatrutide on a bulk in this context is to literally lower LDL, Cholesterol, Triglycerides, increase insulin sensitivity and have better body composition due to its partial glucagon receptor activity burning an arbitrary number of calories. Your bloodwork improvements from "low dose sema" - whatever that means lol are from you not stuffing your face with garbage because you physically cant.

These other random benefits you are talking about make little sense. GLP-1 agonists show promising anti-inflammatory and immune-modulating effects. But randomized clinical trial evidence that they treat or prevent autoimmune diseases in otherwise healthy, lean athletes do not exist. They look like adjuncts for metabolically unhealthy diseased patients, not universal immune therapies

 

[songsofpyramids]

Youre typing emotional non sense like most PEDs do brother.

With all due respect brother you’re the one having an emotional and factless response to this. If you don’t like glp1 that’s fine, but ignoring their incredible benefits because “it’s for fat people” is just stupid.

Your bloodwork improvements from "low dose sema" - whatever that means lol are from you not stuffing your face with garbage because you physically cant.

Sema has literally no impact on my appetite unless I go over a dose threshold. I honestly don’t know what to tell you if you can’t divine what “low dose” means. I have never been overweight and have had a clean healthy diet and participated in sports my whole life. Your presupposition about me being fat for using a drug is just fucking wrong and paints you as ignorant. There’s a whole lot of people and coaches using these drugs with incredible success right now, you nor liking that for whatever personal reason is immaterial. Maybe you should actually research this shit before having a such an over emotional response to it?

These other random benefits you are talking about make little sense

Again, this is simply lack of reading and education on glp1 on your part. Just a knee jerk response from ignorance. It is very clear you have not researched these drugs in earnest. I really don’t care if you protect your heart and brain or not while abusing androgens. That’s a personal choice and I’m totally apathetic to your decision. Just don’t in essence lie and pretend you’re informed about a topic that you’re ignorant in.

 

[professionaldyel]

With all due respect brother you’re the one having an emotional and factless response to this. If you don’t like glp1 that’s fine, but ignoring their incredible benefits because “it’s for fat people” is just stupid.




Sema has literally no impact on my appetite unless I go over a dose threshold. I honestly don’t know what to tell you if you can’t divine what “low dose” means. I have never been overweight and have had a clean healthy diet and participated in sports my whole life. Your presupposition about me being fat for using a drug is just fucking wrong and paints you as ignorant. There’s a whole lot of people and coaches using these drugs with incredible success right now, you nor liking that for whatever personal reason is immaterial. Maybe you should actually research this shit before having a such an over emotional response to it?



Again, this is simply lack of reading and education on glp1 on your part. Just a knee jerk response from ignorance. It is very clear you have not researched these drugs in earnest. I really don’t care if you protect your heart and brain or not while abusing androgens. That’s a personal choice and I’m totally apathetic to your decision. Just don’t in essence lie and pretend you’re informed about a topic that you’re ignorant in.

Youre using "glp1" like a random buzzword and clearly dont understand how Sema, Triz, and Reta are different or how they work, you're legit just spewing non sense and you really need to do your own research or cop out and use chatgpt to dumb it down for you.

Semaglutide's MAX OUT FDA approved injectable dose is 2.4mg per week and again, just like Reta the dose gets escalated every couple of weeks

Semaglutide's Mechanism is being a GLP1 agonist which is the most potent of the three when it comes to appetite suppression and delayed gastric emptying to the point where people get TERRIBLE side effects because its so strong.

Presupposition? There isn't one. I said your bloodwork improved because you stopped eating like shit because its near impossible to eat on Semaglutide. I'm lean, have 1 off plan meal and snack PER DAY. I'm aware its possible to do all of that and NOT be fat but alas - the typical emotional PED forum user.

Theres a whole lot of OUT OF SHAPE people with bad habits using these drugs but - remember this conversation is about retatrutide but you're too stupid to grasp that- Who aren't using 1-2mg a week on a BULK because its near pointless when you have what I previously stated on lock.

The funniest part of this is Ive been using reta off and on since it was available to buy and I genuinely believe that it specifically is going to drastically drop obesity rates with less side effects and negative health outcomes in America after it passes phase 3 trials + the FDA review and comes to market.

You really need to buckle down your education on the topic before barking off like a chihuahua

 

[keengkong]

So i do understand that most of the fatloss from well Reta comes from the appetite surpression through the GLP-1 action (like with Sema and Tirz).

However the real "fatloss" /"fatburning" effect meaning lipolysis comes from the Glucagon action (GCGR) and also higher Insulinsensitivity (GIP)

So why arent we seeing GCGR + GIP agonists?

Would that be very interesting form "us" as a fatburner that we can take for a long time with rather minimal sides compared to other fatburners like Clen? Basically like the fatburning effect of GH.

Or is exactly the problem that its only for us interesting and for obese people this simply wont result in enough fatloss?

Or what am i missing here?

Glucagon agonists have been studied by themselves. When used without GLP-1, people don't lose weight and their glucose levels go up.

 

[songsofpyramids]

Youre using "glp1" like a random buzzword and clearly dont understand how Sema, Triz, and Reta are different or how they work, you're legit just spewing non sense and you really need to do your own research or cop out and use chatgpt to dumb it down for you.

Semaglutide's MAX OUT FDA approved injectable dose is 2.4mg per week and again, just like Reta the dose gets escalated every couple of weeks

Semaglutide's Mechanism is being a GLP1 agonist which is the most potent of the three when it comes to appetite suppression and delayed gastric emptying to the point where people get TERRIBLE side effects because its so strong.

Presupposition? There isn't one. I said your bloodwork improved because you stopped eating like shit because its near impossible to eat on Semaglutide. I'm lean, have 1 off plan meal and snack PER DAY. I'm aware its possible to do all of that and NOT be fat but alas - the typical emotional PED forum user.

Theres a whole lot of OUT OF SHAPE people with bad habits using these drugs but - remember this conversation is about retatrutide but you're too stupid to grasp that- Who aren't using 1-2mg a week on a BULK because its near pointless when you have what I previously stated on lock.

The funniest part of this is Ive been using reta off and on since it was available to buy and I genuinely believe that it specifically is going to drastically drop obesity rates with less side effects and negative health outcomes in America after it passes phase 3 trials + the FDA review and comes to market.

You really need to buckle down your education on the topic before barking off like a chihuahua

Nice irrelevant barely on topic ranting. You’re too over emotional to take seriously acting like this, especially when there are examples of guys way fucking bigger than you bulking on Reta in this very thread that you were too lazy to read.

Have a better day champ.

 

[joemidlife]

Yeah, GCGR is tricky. Too much activation and you risk hyperglycemia or liver strain. It’s probably why pharma sticks with GLP-1 combos.

 

[Lifting88]

There are lots of positive anecdotal reports on here of people using Reta on a bulk. Thus far the phase 3 trials of Reta have reported tons of positive impact as well. I personally find incredible health benefits from low dose sema both cutting and bulking. It has improved my blood work drastically and even reduced my tinnitus.

What the dose?