What is your current RHR?

[OilCarrier]

Mine was 58 before starting GLP-1. Now 68 on Reta. Didn’t notice much of a change switching from tirz to Reta in terms of heart rate. Also use 5 iu GH and 650 mg week of gear. And a lot (way too much) of caffeine.

how long ago did you start reta?

 

[RockyP]

how long ago did you start reta?

2-3 weeks. Was on tirz for 3 months prior and hr already increased on the Tirz.

 

[OilCarrier]

2-3 weeks. Was on tirz for 3 months prior and hr already increased on the Tirz.

interesting! i thought only reta did that, though only for a month or so. I wonder what causes it. To my assumption it could be your body burning off those visceral fat or liver fat deposits in resting state, elevating metabolism through the thyroid?

 

[johnjay06]

Mine has creeped up to 90. It was sitting at 80ish on ret and hgh eod, but crept back up since swapping to ed again. I have Ivabradine arriving today, hopefully that’ll knock it back down

 

[ganciodestro]

My hematocrit is always between 48 (natural no aas ) and 53 ( max 250 mg testo)
My bp is around 115/120 60/70 depend on day, my hrh is always between 55/65
Now I m on 172 mg testo and 3 ui gh
4+LT WATER daily.
Just 5 mg cialis daily no other med.
Cardio 5/7 time for week after my work out , 30/45 Minutes, bpm between 115/130

My fucking problem is been always hematocrit…

 

[Rogal69]

Interesting seeing so many have had an increase on Reta, I’ve seen that often but haven’t experienced it myself yet. I’ve been on 2mg a week for a 6 weeks and have yet to had an increase. I’m normally 50-55 RHR.

How much cardio do the ones who have had a jump doing just curious?

 

[Slowww]

65 no meds— on 1.15 grams of gear and 7.5iu hgh. Blood pressure around 119/75 nothing crazy.

 

[Kralteramon]

65 no meds— on 1.15 grams of gear and 7.5iu hgh. Blood pressure around 119/75 nothing crazy.

Genetically blessed!

 

[JK1]

Interesting seeing so many have had an increase on Reta, I’ve seen that often but haven’t experienced it myself yet. I’ve been on 2mg a week for a 6 weeks and have yet to had an increase. I’m normally 50-55 RHR.

How much cardio do the ones who have had a jump doing just curious?

Might not just be Reta that's causing it for me but I'm about 3 hours cardio a week.

 

[JK1]

65 no meds— on 1.15 grams of gear and 7.5iu hgh. Blood pressure around 119/75 nothing crazy.

Would you say your a chilled/ low stress person put of interest?

 

[Slowww]

Would you say your a chilled/ low stress person put of interest?

Yes generally. Especially because of my work I’ve got to be extremely patient and manage emotions consistently. While this might have something to do with it, I believe it has to do with the fact that I did long distance running competitively since high school, and boxed competitively as an adult prior to body building. Before steroids and bodybuilding my heart rate was even lower and Echocardiograms showed I had bradycardia, but no negative symptoms.

 

[Kralteramon]

Yes generally. Especially because of my work I’ve got to be extremely patient and manage emotions consistently. While this might have something to do with it, I believe it has to do with the fact that I did long distance running competitively since high school, and boxed competitively as an adult prior to body building. Before steroids and bodybuilding my heart rate was even lower and Echocardiograms showed I had bradycardia, but no negative symptoms.

Okay so it's still + 20-25bpm from your baseline, makes more sense.

 

[adrenalytic]

interesting! i thought only reta did that, though only for a month or so. I wonder what causes it. To my assumption it could be your body burning off those visceral fat or liver fat deposits in resting state, elevating metabolism through the thyroid?

all GLP-1 agonists increase RHR by increasing sympathetic tone and decreasing parasympathetic input.

The increase is more pronounced in reta due to the glucagon receptor agonism element which increases cAMP in cardiomyocytes, enhancing pacemaker activity and contractility.

Interesting seeing so many have had an increase on Reta, I’ve seen that often but haven’t experienced it myself yet. I’ve been on 2mg a week for a 6 weeks and have yet to had an increase. I’m normally 50-55 RHR.

How much cardio do the ones who have had a jump doing just curious?

4 mg is the sweet spot for glucagon agonism which is the whole reason for using reta over others. Eli Lilly stopped using 2 mg control groups because there was no measurable response in terms of glucagon receptor agonism.

I also saw no RHR increase at 2mg but as soon as I bumped to 4 mg my RHR went up by 10 BPM almost immediately.

 

[NotHuman]

all GLP-1 agonists increase RHR by increasing sympathetic tone and decreasing parasympathetic input.

The increase is more pronounced in reta due to the glucagon receptor agonism element which increases cAMP in cardiomyocytes, enhancing pacemaker activity and contractility.



4 mg is the sweet spot for glucagon agonism which is the whole reason for using reta over others. Eli Lilly stopped using 2 mg control groups because there was no measurable response in terms of glucagon receptor agonism.

I also saw no RHR increase at 2mg but as soon as I bumped to 4 mg my RHR went up by 10 BPM almost immediately.

To be clear, there were noticeable fat and visceral fat loss benefits in doses as low as 1mg in the trials (as well as A1C reduction). I know you’re talking about glucagon but that needs to be said so people don’t think it’s ineffective at lower doses than 4mg.

 

[monster8912]

Currently on 500 test prop, tren ace, mast prop. 65 rhr. Was usually right about 50 before this cycle. Also not doing much cardio and terrible sleep with a new born so lots of factors increasing it.

 

[JK1]

For those using ivabradine alone, or combining it with nebivolol for heart rate reduction, what are your thoughts on timing and dosing?

Appreciate any input.

 

[Eddie.]

For those using ivabradine alone, or combining it with nebivolol for heart rate reduction, what are your thoughts on timing and dosing?

Appreciate any input.

Twice a day AM/PM with a meal. I would recomment starting straight with 5mg each dose, it seems that 10mg per day is the happy medium. I have a friend who was hesitant on this drug, started with 2,5 twice a day and RHR didn't moved at all and he quited.

I doubt 5mg a day is doing anything, and if it does actually lowers 3-4 beats still doesn't worth taking an extra substance for doing so little.

I ran couple boxes at 10mg and currently taking the max dose of 15mg (7,5x2) but the difference between 10 and 15 is negligible.

 

[JK1]

10mg of ivabradine doesn't seem to be reducing my nighttime rhr at all. I'm assuming it should be a immediate effect. That was me taking 10mg at night.

Granted i am not as high as some of you. Im at around 61 up from 45-47.

Not sure what to try next. Maybe add nebivolol? Or just accept it.

Perhaps if I was 80+ I'd see a change.

 

[Liter O' Test]

View attachment 350745View attachment 350746
I just want to start off by saying this is an excellent thread. Been following along and it really hits home with where I’m at right now.

For context: I ran an 18-week blast starting back in April, and the effect on my HRV and resting heart rate was dramatic both went downhill badly. What’s concerning is that things still haven’t bounced back the way I’d expected.

I should add that I’ve been running GH consistently since January (pretty low 2–3 IU most days). Reta only came into the picture in July, and I’ve gradually brought that up to ~3 mg per week. So while the hgh and reta are no doubt additive, in my case it really feels like the blast was the main driver. It wasn't even a blasting many people's books. Modest test only as I respond well. Back on Cruise.

Before this, I had decent hrv swings and decent recovery markers. Now it’s like I’ve lost that flexibility altogether, and none of the above seems to be moving the needle. Honestly, it’s a concern.

Next step for me is testing Ivabradine to see if that can help reset things a bit.

Curious if anyone else here has noticed the same persistence in elevated resting heart rate / trashed HRV post-blast, and what’s actually made a difference in recovery for you.

any update?

 

[JK1]

any update?

I am literally on here now, looking around some posts to try and decide what to do. Then seen this.

I don't have much of anyting useful to report!

Bottom line is - havent had a return to my previous rhr or HRV variability at all.

Now i definitely haven't ended up going that high compared to most i accept. I now sit up at around 68rhr and used to sit at 44-47. The HRV flatlining is one hell of a bit of data to see though - i just accept that having higher T is clearly quite a sympathetic driver for me- eben on 150mg/week test.

I could run through my dosing of iva and nebiv which i fiddled around with and granted i wasnt maxing out more than 10mg of each and i wasnt doing twice a day either. So its not a fair experiment.

I would say the AM blunting of HR during CV isn't something that bothers me too much but this morning was much worse for some reason i can sit at 125- 135 eventually after a delay and couldn't get above 105 this morning with same perceived exertion.

I may have to accept the situation. I do wonder if it went up to 80-100 then maybe thats where i'd see the iva and/or nebiv act more.