Switching from Tirzepatide (15mg) to Retatrutide ?

[dao_]

Hello everyone,

I was on Semaglutide last year , I’m currently on 15 mg weekly for 2 months tirzepatide (Moun-jaro) and I’m considering switching to retatrutide because I am not losing weight anymore.

For those who have made a similar change, could you please share what starting dose you used ?
Should I go for Cagrilintide ?

165cm
June 2024: 120kg
Now: 90kg

Thank you in advance for any insights

 

[RockyP]

33.4% body fat percentage
Muscle 59kg
Actual weight: 92kg
1691kcal BMR
Source: My Renpho weight scale
I'm doing 20 push-up a week
Right now around 10k step per week

Ok this is helpful. Do you have a sense of how many calories you are eating, and what the macronutrient breakdown is (protein, carbs, fat)?

Once we know that information we can better help with diet advice.

Also, it would be very beneficial to start a resistance training / weight lifting program.

 

[pewex]

My response isn't as scientific as @Ghoul or others, but I've used both Reta and Tirz. I went up to 2.5mg Tirz and 15mg of Reta. For me, Reta did absolutely nothing for hunger, meanwhile, the first time I used Tirz, it completely wiped out my appetite.

Since you don't track calories or follow a structured lifting routine with a set diet, I feel like Reta would leave you feeling less satiated and you'd end up eating more. Personally, I'd either increase the Tirz dose or add cagri.

In the end, there's no magic to it. just remember: calories in < calories out.

 

[Ghoul]

My response isn't as scientific as @Ghoul or others, but I've used both Reta and Tirz. I went up to 2.5mg Tirz and 15mg of Reta. For me, Reta did absolutely nothing for hunger, meanwhile, the first time I used Tirz, it completely wiped out my appetite.

Since you don't track calories or follow a structured lifting routine with a set diet, I feel like Reta would leave you feeling less satiated and you'd end up eating more. Personally, I'd either increase the Tirz dose or add cagri.

In the end, there's no magic to it. just remember: calories in < calories out.

I can’t explain it, but casually that’s what I observe too. Reta doesnt seem to be as effective for appetite suppression for many as the alternatives. Yet the clinical trials show it should be MORE effective for weight loss.

I don’t know, maybe it’s something about UGL that’s different vs Pharma we haven’t figured out yet.

 

[RockyP]

Much like the oft-cited study of men taking testosterone getting better body metric results without exercise than the men who exercised naturally, you can administer GLP-1's to anyone and they will lose some weight. However, for those with longer weight loss journeys, they're going to need more levers to pull. Resistance training, strict calorie counting, re-feeds / maintenance calorie phases, etc.

But this is a start at least..

 

[dao_]

Much like the oft-cited study of men taking testosterone getting better body metric results without exercise than the men who exercised naturally, you can administer GLP-1's to anyone and they will lose some weight. However, for those with longer weight loss journeys, they're going to need more levers to pull. Resistance training, strict calorie counting, re-feeds / maintenance calorie phases, etc.

But this is a start at least..

"re-feeds / maintenance calorie phases,"
Can you please explain why?

 

[thejumpingsheep]

I can’t explain it, but casually that’s what I observe too. Reta doesnt seem to be as effective for appetite suppression for many as the alternatives. Yet the clinical trials show it should be MORE effective for weight loss.

I don’t know, maybe it’s something about UGL that’s different vs Pharma we haven’t figured out yet.

Im testing Reta right now and I think (more like I am hoping) its success is related to anti-inflammatory properties more than appetite suppression. Thats just a theory but there are trials that showed amazing anti-inflammatory response to Reta. Granted it was people with fatty liver, but combine this with the weight loss from trials being more effective, and it made me wonder if it isnt actually helping in muscle recovery and allowing people to be more physically active. This tracks with anecdotal reports that people feel less lethargic with Reta compared to Tirz or Sema.

So im testing it. FWIW, I got zero appetite suppression until I hit about 30mg at week 2. Week 3 definitely has suppression now. I know it takes 3-4 week to saturate Reta but I wanted to accelerate things a bit. In my case I dont need the appetite suppression anyway. I want to test the anti-inflammatory response. Also note I was on Tirz max dose about a year prior. I dropped it once I hit weight and BF% target. Didnt need it any more, but my body is adapted to these GLP1 blockers which probably explains why I needed higher doses.

I tried 10mg and it did nothing. I added another 10mg about 5 days later. Still nothing. I did 10mg at around day 12 and it kicked in. I figure im at maybe 75% saturation since I accelerated things and my maintain dosage will likely be 6mg to 8mg a week from here on. Ill pull labs in a couple of weeks to check markers.

Again im looking for liver detox and anti-inflammatory response and, of course, workout recovery. The appetite suppression is there but my diet is dialed in at this point and all Ive had to do is eat less portion but more frequent to override the suppression. No biggie.

What I can say so far, is my cardio has suddenly gotten a big boost almost overnight. What used to exhaust me just 2 weeks ago, is suddenly easy and I can keep running if I want to. I hold myself back due to knees, but I could keep going and this came on just this last week or so. Im in cruise right now.

 

[jahbong]

brahh 30mg of reta, thats wild. I'll keep upping my dose until I actually feel effects. Im currently at 4mg, but I can NOT eat if I want to, but I still eat anyway. But when I first started at 1mg, I had zero appetite at all. I want that feeling back. I went a whole day without eating, just drinking my electrolyes.

I'll up the dose to either 6mg or go straight to 8mg once this bottle is done. I'll stay on reta until my kit is done, if nothing improves, I got 2 40mg kits of tirz on the way.

 

[thejumpingsheep]

I just saw the news on updated trial reports. Figured I would update as well.

So all things being equal, and im still on cruise right now and just taking Reta. I should be at full saturation at this point.

First the news is claiming knee support. Well im about 4 weeks in and I cant say I noticed that at all. I have knee issues and mild arthritis so that would be huge and aligns with its anti-inflammatory properties (this is what I was hoping for). But alas, no change so far. Maybe it takes more time?

For me, appetite suppression is nothing like Tirz but then again Tirz started to get less effective as I reached my weight goals. So im not going to declare it less effective, rather I think my body has adjusted.

Here is the major change:

Holy shit can I cardio better now... I mean its a shocking change in a small amount of time. Under Tirz, I was about the same weight as I am now, but cardio was a chore. But more importantly, even during the year without Tirz or any GLP blocker, I struggled with running. I was doing 9-10 minute miles (Im old) and I just wanted it to be over. Now, the last 2 weeks, I can run 8 minute miles and I can go faster and keep going longer if I want to. I dont because I dont want to flare up knees but I can.

I am not sure what to make of this. Too early to say. Maybe it has nothing to do with Reta and my motor suddenly improved? Coincedental perhaps? Maybe... but I was struggling with running for well over 1.5 year without improvement and little to no weight change.

I havent pulled bloods yet. This will be the most important test. What I want to see is AST/ALT lower than my historic ranges. I havent been sick and generally I dont pull bloods when sick. If I get notable LDL and HDL improvements that will be big too. Might stick to it a little longer to see if the claim about knees is real.