MESO-Rx Sponsor STANFORD PHARMA PUBLIC SALE 10/24/21

[bigdaddyandfriends]

Not at all. It crashes it when I run primo at 600mgs even with 750 test. Maybe as time goes on it will but I’m about 5 weeks in. Great results and libido with this stack and dosages.

If primo or a metabolite is in fact an aromatase inhibitor then this would make perfect sense.

At some threshold dose of AI, essentially all aromatase gets deactivated and no aromatization of testosterone (or trestolone/nandrolone) occurs. These are the doses of prescribed AI drugs to knock out essentially all (~99%) aromatase:

Exemestate/Aromasin - 25mg/day
Anastrozole/Arimidex - 1mg/day
Letrozole/Femara - 2.5mg/day

Not surprisingly, these are the doses for breast CA hormonal therapy where total E2 deprivation is the clinical goal. Primo is obviously not nearly as efficient/potent, but let's say for discussion it is 100mg/day = 700mg/wk.

At 350mg/wk primo, if half the aromatase gets deactivated, a test dose of 300mg/wk will still convert to half the E2 it would w/o primo, so similar E2 as 150mg/wk test - which is still far more than the body produces naturally and therefore more than sufficient to provide physiologic estradiol.. some need a little AI support even at a 'low' TRT dose of 140mg/wk test to keep E2 in range.

Now double to 700mg/wk and all the aromatase becomes deactivated, so E2 conversion from testosterone is halted, regardless of how much test is available. Ultimately the absolute dose of primobolan is far more important than the test to primo ratio.

Nandrolone may indeed offset these effects somewhat as it seems to either upregulate aromatase production and/or sensitize estrogen receptors to estradiol - which is why adding it to a cycle often results in high E2 symptoms ie gyno, water retention, acne, etc despite itself being a very poor candidate for aromatase. Hence why nandrolone-only cycles require extremely high doses to achieve physiologic E2 levels.

 

[QuadFather]

Nothing beats that tren-charged feeling of heading to the gym, sipping a Monster,
cause I can’t put mine in bro’

 

[Zc7219]

Now double to 700mg/wk and all the aromatase becomes deactivated, so E2 conversion from testosterone is halted, regardless of how much test is available. Ultimately the absolute dose of primobolan is far more important than the test to

Need 12.5 aromasin every day on 600 test for a 30-40 e2.


600 test with 200 primo has me at 20 e2


My buddy can run 800-1000 primo with TRT test with zero issue.

 

[Ligament]

I was hoping primo would control my E2, but it doens't seem to touch it, at low doses at least

 

[RockyP]

Need 12.5 aromasin every day on 600 test for a 30-40 e2.


600 test with 200 primo has me at 20 e2


My buddy can run 800-1000 primo with TRT test with zero issue.

I think your buddy has fake primo

 

[The Answ3r]

I was hoping primo would control my E2, but it doens't seem to touch it, at low doses at least

Next time, give EQ a shot at a 1:1 ratio - it’s like Primo’s broke cousin, but it actually knows how to keep E2 in check.

 

[Zc7219]

I think your buddy has fake primo

We both use Stan.

 

[RockyP]

We both use Stan.

Then I am very confused (and jealous) of your buddy being able to run that much primo with an E2 > 0

 

[Muscles’]

Nothing beats that tren-charged feeling of heading to the gym, sipping a Monster,
cause I can’t put mine in bro’

reminds me of rich pianooo, that's going to be my fall cycle, tren, amphetamines, nicotine and test, how's stans tren? never tried him before but looks like grape seed from china is done, maybe stan would lower the minimum for a quality member like myself?

 

[Darealme83]

reminds me of rich pianooo, that's going to be my fall cycle, tren, amphetamines, nicotine and test, how's stans tren? never tried him before but looks like grape seed from china is done, maybe stan would lower the minimum for a quality member like myself?

I have used Stan’s Tren and it’s amazing. No PIP.
I use his Tren Ace.

 

[Tbaz192]

reminds me of rich pianooo, that's going to be my fall cycle, tren, amphetamines, nicotine and test, how's stans tren? never tried him before but looks like grape seed from china is done, maybe stan would lower the minimum for a quality member like myself?

Stan’s Tren E had veins coming out in places I didn’t know existed. Libido was thru the roof it was infuriating. Was strong and lifting hard as fuck. Wish I could run it again

 

[Muscles’]

I have used Stan’s Tren and it’s amazing. No PIP.
I use his Tren Ace.

Stan’s Tren E had veins coming out in places I didn’t know existed. Libido was thru the roof it was infuriating. Was strong and lifting hard as fuck. Wish I could run it again

yea, just waiting for stan to say he will lower the minimum to one vial of tren then maybe I'd give him a try

 

[Darealme83]

Stan’s Tren E had veins coming out in places I didn’t know existed. Libido was thru the roof it was infuriating. Was strong and lifting hard as fuck. Wish I could run it again

Yeah Tren Ace

yea, just waiting for stan to say he will lower the minimum to one vial of tren then maybe I'd give him a try

lower the minimum to one vial and MAYBE you would give it a try?

Pffffffft.

 

[Anonymous member 154437]

yea, just waiting for stan to say he will lower the minimum to one vial of tren then maybe I'd give him a try

I bet he’d love having the honor of serving you as a customer

 

[Muscles’]

I bet he’d love having the honor of serving you as a customer

Exactly brother I think so too

 

[Slicknyc]

If primo or a metabolite is in fact an aromatase inhibitor then this would make perfect sense.

At some threshold dose of AI, essentially all aromatase gets deactivated and no aromatization of testosterone (or trestolone/nandrolone) occurs. These are the doses of prescribed AI drugs to knock out essentially all (~99%) aromatase:

Exemestate/Aromasin - 25mg/day
Anastrozole/Arimidex - 1mg/day
Letrozole/Femara - 2.5mg/day

Not surprisingly, these are the doses for breast CA hormonal therapy where total E2 deprivation is the clinical goal. Primo is obviously not nearly as efficient/potent, but let's say for discussion it is 100mg/day = 700mg/wk.

At 350mg/wk primo, if half the aromatase gets deactivated, a test dose of 300mg/wk will still convert to half the E2 it would w/o primo, so similar E2 as 150mg/wk test - which is still far more than the body produces naturally and therefore more than sufficient to provide physiologic estradiol.. some need a little AI support even at a 'low' TRT dose of 140mg/wk test to keep E2 in range.

Now double to 700mg/wk and all the aromatase becomes deactivated, so E2 conversion from testosterone is halted, regardless of how much test is available. Ultimately the absolute dose of primobolan is far more important than the test to primo ratio.

Nandrolone may indeed offset these effects somewhat as it seems to either upregulate aromatase production and/or sensitize estrogen receptors to estradiol - which is why adding it to a cycle often results in high E2 symptoms ie gyno, water retention, acne, etc despite itself being a very poor candidate for aromatase. Hence why nandrolone-only cycles require extremely high doses to achieve physiologic E2 levels.

Thank you so much for explaining this to me as I was still a bit confused as to what exactly is going on. I just know that this is definitely a sweet spot but am curious as to how much primo I could run without complications. I bumped to 450 and was thinking of 500 but after reading your post I’m gonna stay right where I’m at or maybe even cut down to 400.

 

[Tbaz192]

Yeah Tren Ace

Last run with Tren ace I had zero sides at 400 a week. Was interesting given Tren E 200 2X a week was way different. Made me question the cycle every day. Like hmmm Tren ace should be hitting way harder & I’m feeling nothing side effect wise.

 

[cajunpauper]

Last run with Tren ace I had zero sides at 400 a week. Was interesting given Tren E 200 2X a week was way different. Made me question the cycle every day. Like hmmm Tren ace should be hitting way harder & I’m feeling nothing side effect wise.

Given some preventative prami dosing, I've had relatively low sides from Tren Ace at 200/ wk. Outside of some thinned patience, I've found it far more tolerable at low doses with most of the benefits from a high dose, with far less sides.

 

[Muscles’]

Last time I ran Tren I’m almost positive my Tia wanted me to do dirty things to her. Can’t wait to run it again and see if that’s still the case. Hopefully by the fall I can get my hands on some of stannys tren

 

[RockyP]

Given some preventative prami dosing, I've had relatively low sides from Tren Ace at 200/ wk. Outside of some thinned patience, I've found it far more tolerable at low doses with most of the benefits from a high dose, with far less sides.

I'm 235 lbs and I don't go above 60 mg weekly of Tren E (pin 20 mg EOD) - no side effects and plenty of benefits. I did the 100 mg EOD of tren ace in my 20's. I was lucky to tolerate it well but I've found that the effects are the same with a dose as low as 50 - 70 mg weekly of enanthate. Also the longer ester mitigates sides that come from fluctuations in blood levels. Of course, if you get uncomfortable sides they will stick around longer with enanthate or hex.

I've heard time and time again that the top guys in the 90's never went above 2 to 3 parabolan amps per week. I have no idea how the culture of mega dosing tren came about but it is insanity.