some peptides make you sick?

[Juicedhead]

so I started this crazy myostatin stack just cuz I have all these peptides on hand. Heres the stack

folli 344 300mg eod
folli 315 300mg eod
ace-031 300mg oed
myo hmp 300mg eod

So far gains have been absolutly INSANE. But I noticed I got a weird fever/felt sick for about 12 hrs a couple days afer injecting. Ive only done 3 shots so far already up 10 lbs in about 10 days. Feel pumped all the time, strength is insane, notice big appetite affter injecting. I want to keep on this stack but im scared to get that fever/sickness again. Any idea what it could be from? I remembe rreading about someting about peptides that are "tagged" But cant seem to find out if these are tagged are not.

 

[RonaldRt]

Bro. Firstly follistatin as far as we know in human data has little no to zero effect on myostatin on shows a drop in mice. Not to mention is EXPENSIVE. For your question though it’s def an immune reaction to the compound being tagged almost certainly.

 

[Type-IIx]

Myostatin inhibitors are associated with nausea especially, at a pretty high prevalence. Even the newer ones like trevogrumab had a prevalence of about 1/3 of patients who experienced significant nausea, and fever was right up there, too, from memory. It could be tied to myostatin inhibition per se, or relate to some lack of selectivity, and cross-reactivity with similar proteins to GDF8.

At least the results are getting a lot more interesting than they were with these older drugs you've listed here [pretty subpar tbh]! This drug class has come pretty far in the last 5-6 years or so.

Some of these early myostatin inhibitors you've listed here – actually most – were discontinued. But there's a lot of active research with newer drugs that inhibit myostatin.

 

[Juicedhead]

Myostatin inhibitors are associated with nausea especially, at a pretty high prevalence. Even the newer ones like trevogrumab had a prevalence of about 1/3 of patients who experienced significant nausea, and fever was right up there, too, from memory. It could be tied to myostatin inhibition per se, or relate to some lack of selectivity, and cross-reactivity with similar proteins to GDF8.

At least the results are getting a lot more interesting than they were with these older drugs you've listed here [pretty subpar tbh]! This drug class has come pretty far in the last 5-6 years or so.

Some of these early myostatin inhibitors you've listed here – actually most – were discontinued. But there's a lot of active research with newer drugs that inhibit myostatin.

i read someting about it having to be tagged to a live virus for it to not be destryoed by the body right away. I think it was E.coli. Have you ever heard that?

 

[Juicedhead]

Bro. Firstly follistatin as far as we know in human data has little no to zero effect on myostatin on shows a drop in mice. Not to mention is EXPENSIVE. For your question though it’s def an immune reaction to the compound being tagged almost certainly.

yeah I know but I have a lot of this shit just sitting here and its def did something not kidding but the effect seemed to stop as soon as you stop taking it. I stopped taking it in fear of getting sick again.

 

[yoyoy]

Melanotan 2 makes me really sick, but works for well for me.

 

[Type-IIx]

i read someting about it having to be tagged to a live virus for it to not be destryoed by the body right away. I think it was E.coli. Have you ever heard that?

GH and peptides are usually manufactured by an E. Coli manufacturing process since E. coli replicates the (eg GH) protein.

It’s “bioengineering,” and how basically all the (recombinant) GH is made, since the 80s – shit – earlier.

It doesn’t get you sick or anything, it’s actually the smartest cleanest way to mass-produce peptides!

 

[Type-IIx]

The latest myostatin inhibitors like trevogrumab are really almost side effect free, like, indistinguishable from placebo. I just put out a podcast about an ongoing clinical trial testing a dual myostatin inhibitor + GLP-1 drug (trevogrumab + semaglutide)

 

[dinfar1337]

The latest myostatin inhibitors like trevogrumab are really almost side effect free, like, indistinguishable from placebo. I just put out a podcast about an ongoing clinical trial testing a dual myostatin inhibitor + GLP-1 drug (trevogrumab + semaglutide)

really? greg deucutte if i spell his name correctly put a video out on debunking mike israetels video about it, neither of them is credible but i just took his word for it. the numbers he is throwing up seems lethal.

1/10 people or 10% will be in hospitalized with life-long disabilites or die.

would love to hear your take on it and look into the drug myself if it becomes affordable.

 

[dinfar1337]

The latest myostatin inhibitors like trevogrumab are really almost side effect free, like, indistinguishable from placebo. I just put out a podcast about an ongoing clinical trial testing a dual myostatin inhibitor + GLP-1 drug (trevogrumab + semaglutide)

found the video on your youtube channel sorry for not reading probably!

 

[Type-IIx]

No clue what he's talking about, the COURAGE prelims are here: https://newsroom.regeneron.com/news...going-phase-2-courage-trial-confirm-potential

Make sure you or he isn't confusing trevogrumab and some other, similarly named drug.

 

[dinfar1337]

No clue what he's talking about, the COURAGE prelims are here: https://newsroom.regeneron.com/news...going-phase-2-courage-trial-confirm-potential

Make sure you or he isn't confusing trevogrumab and some other, similarly named drug.

he is defiently talking about regenerons trevogrumab in his video

 

[Type-IIx]

he is defiently talking about regenerons trevogrumab in his video

Yeah, I believe you. These guys can often be totally wrong. I don't even think they read it… you said he was disagreeing with someone?

It's like a marketing tactic, take a popular video, take an opposite position (even if it's factual rather than the domain of opinion), and generate clicks/ad revenue.

It's actually "The Way" in the fitness industry. I don't like that, it reflects badly on it. He gets to double-dip into ad revenue this way.

What was once "ad copy" is now Instagram Reel rap battles without reading the topic of debate.

 

[dinfar1337]

Yeah, I believe you. These guys can often be totally wrong. I don't even think they read it… you said he was disagreeing with someone?

It's like a marketing tactic, take a popular video, take an opposite position (even if it's factual rather than the domain of opinion), and generate clicks/ad revenue.

It's actually "The Way" in the fitness industry. I don't like that, it reflects badly on it. He gets to double-dip into ad revenue this way.

What was once "ad copy" is now Instagram Reel rap battles without reading the topic of debate.

if you are interested

this video basically blew it up and why everyones talking about trevogrumab

View: https://www.youtube.com/watch?v=nB8qqiTmQc8


and this was kinda like a debunking/clowning reponse video i was talking about.
View: https://www.youtube.com/watch?v=wakPhjCR0RM

 

[Type-IIx]

I know people just like Mike. He's the big name, but I try not to be polluted by watching this stuff, TBH. Thanks for sending, I might (maybe 15-20% chance if I'm honest) watch it at some point. I think he's a very smart guy, smart doesn't mean correct on every point, it means clever.

 

[dinfar1337]

I know people just like Mike. He's the big name, but I try not to be polluted by watching this stuff, TBH. Thanks for sending, I might (maybe 15-20% chance if I'm honest) watch it at some point. I think he's a very smart guy, smart doesn't mean correct on every point, it means clever.

you're very nice in your speech, he is a fucking monkey!

 

[Type-IIx]

GLP-1 Agonists and Myostatin Inhibitors: New Data (00:11:32)
Introduces the COURAGE trial and the rationale for combining GLP-1 agonists with trevogrumab.

Strategies to Preserve Muscle on GLP-1 Drugs (00:12:38)
Outlines three strategies to maintain muscle while using GLP-1 drugs, focusing on drug interventions.

Myostatin Inhibitors: Mechanisms and Trials (00:13:48)
Reviews the history, mechanisms, and clinical trials of trevogrumab, including new combination therapies.

COURAGE Trial Results and Drug Synergy (00:14:59)
Details the Courage trial’s experimental groups, results, and the synergy of combining trevogrumab with GLP-1 drugs.

Molecular Pathways in Muscle Growth (00:15:59)
Explains the molecular signaling pathways involved in muscle growth and how different drugs interact.

Safety and Side Effects of Myostatin/Activin-A Inhibitors (00:16:14)
Discusses the safety profile of new myostatin inhibitors like trevogrumab and the side effects of anti-activin A drugs.

 

[Type-IIx]

Myostatin inhibitors are associated with nausea especially, at a pretty high prevalence. Even the newer ones like trevogrumab had a prevalence of about 1/3 of patients who experienced significant nausea, and fever was right up there, too, from memory. It could be tied to myostatin inhibition per se, or relate to some lack of selectivity, and cross-reactivity with similar proteins to GDF8.

At least the results are getting a lot more interesting than they were with these older drugs you've listed here [pretty subpar tbh]! This drug class has come pretty far in the last 5-6 years or so.

Some of these early myostatin inhibitors you've listed here – actually most – were discontinued. But there's a lot of active research with newer drugs that inhibit myostatin.

I was wrong here, it was not trevogrumab, but the anti-activin A drug that caused this prevalence of side effects.

And it was weird shit (!) like eyebrow loss, UTIs, mouth sores, and nosebleeds. 112 people refused to continue on the anti-activin A addition.

But trevogrumab the myostatin inhibitor was very well tolerated.

 

[frenexen]

I was wrong here, it was not trevogrumab, but the anti-activin A drug that caused this prevalence of side effects.

And it was weird shit (!) like eyebrow loss, UTIs, mouth sores, and nosebleeds. 112 people refused to continue on the anti-activin A addition.

But trevogrumab the myostatin inhibitor was very well tolerated.

Keep your eye on Apitegromab. I think more are talking about the others just because of Mike.

It’s been a while since I’ve looked into the studies so take with a grain of salt, but Apitegromab seemed to not lose effectiveness, while Trevogrumab eventually lost effectiveness as myostatin rebounded over time. Apitegromab selectively targets latent myostatin instead.

Fast tracked for SMA, completed phase 3, in phase 2 trials for weight loss.

 

[Type-IIx]

so I started this crazy myostatin stack just cuz I have all these peptides on hand. Heres the stack

folli 344 300mg eod
folli 315 300mg eod
ace-031 300mg oed
myo hmp 300mg eod

So far gains have been absolutly INSANE. But I noticed I got a weird fever/felt sick for about 12 hrs a couple days afer injecting. Ive only done 3 shots so far already up 10 lbs in about 10 days. Feel pumped all the time, strength is insane, notice big appetite affter injecting. I want to keep on this stack but im scared to get that fever/sickness again. Any idea what it could be from? I remembe rreading about someting about peptides that are "tagged" But cant seem to find out if these are tagged are not.

Hey bro, I wanted to come back to this because I'm following a class of premyostatin inhibitors, we'll call them, and the latest trials are finding that they are well-tolerated but, indeed, at a rate of about 25%, people experienced pyrexia (fever), cough, vomiting, upper respiratory tract infection, and headache.

While no patients discontinued due to adverse events, that sure sounds a lot like being sick.