SLU-PP-332 Dosing Confusion – Anyone Familiar with Receptor Activity / Best Practices?

[Matthex69]

Hey everyone,

I’ve been looking into SLU-PP-332 recently and noticed a huge discrepancy in dosing recommendations. Most fitness/biochem guys like Vigorous Steve suggest doses between 250 mcg and 1 mg max. But then you’ve got Chinese vendors selling 20 mg tablets, and a lot of users report feeling absolutely nothing at 1 mg only at much higher doses do they start to feel the real effects.

So what’s the deal here? Does anyone actually understand the mechanism of action, especially which receptors SLU-PP-332 activates ERRα and ERRγ and how that ties into effective dosing?

I’m also curious what the best timing strategy would be for taking it, and whether this compound needs to be cycled or if it can be taken continuously. Do you need to build up tolerance before it kicks in?

 

[cmK9s33]

SSA has 5-Amino-1mq 50mg and SLU-PP-32 (250mcg and 20mg). I've ordered both today.

The 5-Amino-1mq and SLU-PP-32 (250mcg) don't have Jano tests, but the 20mg version does.

Janoshik Analytical

For what it's worth, I sent a sample of their SLU (250ug) to Jano and came back as 296 ug per tab.

 

[Mariafitness]

For what it's worth, I sent a sample of their SLU (250ug) to Jano and came back as 296 ug per tab.

How did it feel?

 

[paulbras]

So whats the consensus here?? I got raws arriving in the next couple of days from SSA and need to figure out the dose on these capsules. Got 20g 5amino and 20g Slupp332 from SSA. 5 amino will be 50mg caps 3x a day. Slu I still have no clue.

 

[Ateam2023]

So whats the consensus here?? I got raws arriving in the next couple of days from SSA and need to figure out the dose on these capsules. Got 20g 5amino and 20g Slupp332 from SSA. 5 amino will be 50mg caps 3x a day. Slu I still have no clue.

tbh, i don't think Anyone has the Slupp dosing figured out, its kinda like "pick your dose" and compare notes, bloodwork etc, i dont know what bloodwork exactly to monitor, (but getting a baseline on the generalized bloods) , but the dosing is all over the place as far as individual "risk tolerance ", i have been doing 80 mg a day split am/early afternoon and have been taking this Slupp shit since January,, I was already dialed in as far as diet , training, and the only thing thats really changed is my Cystatin c has been elevated, i don't know if the Slupp is causing that or something else (in process of imaging of kidneys/liver) ,, YMMV , keep us updated when you start your Slupp run,,

 

[paulbras]

tbh, i don't think Anyone has the Slupp dosing figured out, its kinda like "pick your dose" and compare notes, bloodwork etc, i dont know what bloodwork exactly to monitor, (but getting a baseline on the generalized bloods) , but the dosing is all over the place as far as individual "risk tolerance ", i have been doing 80 mg a day split am/early afternoon and have been taking this Slupp shit since January,, I was already dialed in as far as diet , training, and the only thing thats really changed is my Cystatin c has been elevated, i don't know if the Slupp is causing that or something else (in process of imaging of kidneys/liver) ,, YMMV , keep us updated when you start your Slupp run,,

Is it possible to share where you got your raw from? I think that's another thing people should be considering and comparing is where the product is coming from. One supplier might have difference from another supplier as far as efficacy goes, even between batches of the same supplier. As I said mine is coming in from SSA and should be here next week since tomorrow is a holiday.

 

[Ateam2023]

Is it possible to share where you got your raw from? I think that's another thing people should be considering and comparing is where the product is coming from. One supplier might have difference from another supplier as far as efficacy goes, even between batches of the same supplier. As I said mine is coming in from SSA and should be here next week since tomorrow is a holiday.

i sourced the 20 mg pills Ssa offered last year in a promo,,

 

[Ateam2023]

Is it possible to share where you got your raw from? I think that's another thing people should be considering and comparing is where the product is coming from. One supplier might have difference from another supplier as far as efficacy goes, even between batches of the same supplier. As I said mine is coming in from SSA and should be here next week since tomorrow is a holiday.

definitely pull bloods for inflammation markers, Cystatin c , ggt, Crp etc, also a cbc/cmp panel , if any otheres could add to that list of markers to check that would be beneficial also,,

 

[xrayphoton13]

So whats the consensus here?? I got raws arriving in the next couple of days from SSA and need to figure out the dose on these capsules. Got 20g 5amino and 20g Slupp332 from SSA. 5 amino will be 50mg caps 3x a day. Slu I still have no clue.

No one knows man. That's why I think it's either placebo or very weak and needs a few more iterations before exercise mimetics are worth buying. Some say 250mcg works great. Others say 750mcg. Then you the have some saying no you need 20mg and still others saying you need 50-100mg per day.
I'll just stick with EC stack with occasional yohimbine or run clen.

 

[AllGoodThings]

I remember reading that there was some doubt as to its oral bioavailability, something about the pH in the stomach rendering it innert. I have some that came in enteric capsules, which could help, if the above is true. Is there any consensus on this?

 

[Ateam2023]

I remember reading that there was some doubt as to its oral bioavailability, something about the pH in the stomach rendering it innert. I have some that came in enteric capsules, which could help, if the above is true. Is there any consensus on this?

If you could post that reference that you read ? Or point us to right direction? Tia

 

[AllGoodThings]

A brief search didn't lead me to whatever it was that I had read. I've noticed a few sources using enteric capsules, so it could have some legitimacy. The only information I found was an ~45% bioavailability in rodent models, which really isn't too bad. I know of at least one source offering it in injectable form, but no real information regarding dosing, injection frequency, or any real, usable info for that route of administration. I'm wondering if some of the non responders would benefit from an increase in bioavailability from subq vs oral. Considering it was synthesized some 20 years ago, it doesn't seem we're likely to see human trials at any point. Do we know why research into it was discontinued?

 

[amazonas]

SSA has 5-Amino-1mq 50mg and SLU-PP-32 (250mcg and 20mg). I've ordered both today.

The 5-Amino-1mq and SLU-PP-32 (250mcg) don't have Jano tests, but the 20mg version does.

Janoshik Analytical

How is your experience with the 5-Amino-1MQ so far?
@Sampei as well

 

[Kralteramon]

A 1:1 ratio for SLUPP mice dosage would be in the 2-4 g range

I think it's a lot more. I know people who use 30mg+ per day with amazing results.

• Mouse studies often use 5–10 mg/kg daily, orally or via IP injection.
• Based on standard allometric scaling, this translates to approximately:

~0.4–0.8 mg/kg in humans
For an 80 kg person → ~30–65 mg/day

People have been super conservative with dosing because of price.

 

[amazonas]

I think it's a lot more. I know people who use 30mg+ per day with amazing results.

• Mouse studies often use 5–10 mg/kg daily, orally or via IP injection.
• Based on standard allometric scaling, this translates to approximately:

People have been super conservative with dosing because of price.

SLU-PP-332 500mcg didnt do shit for me, but switching over to 20mg was a game changer. Very noticeable fatloss and sweating more and endurance way up during workouts. I tried 40mg for the final two weeks and it was fucking amazing. I will be using this in all my cuts from now on. I was eating worse than before but getting leaner and leaner.

I would love to run it year-round, but my only concern is the lack of long-term studies and human studies.

 

[verylargeshoes]

I think it's a lot more. I know people who use 30mg+ per day with amazing results.

• Mouse studies often use 5–10 mg/kg daily, orally or via IP injection.
• Based on standard allometric scaling, this translates to approximately:

People have been super conservative with dosing because of price.

Well, that, and because taking 40-160x the dosage everybody else is taking, when the compound has absolutely no human safety data, ought to scare the hell out of you.

I found good deals on 20mg SLU-PP-332 caps and raws and was taking 20-40mg/day until I thought about it for a minute and realized I had just inadvertently donned a guinea pig suit and enrolled in the world’s worst run clinical trial.

20-40mg was giving me pretty good results, but in the end I decided it wasn’t doing anything I couldn’t achieve through better tested means less likely to make my wife a widow.

I am very excited about the future potential of exercise mimetics. I don’t expect they’ll be on the legitimate market in time for me to benefit, but the potential benefits to a population drowning in diabetes and metabolic syndrome and NAFLD are tremendous.

 

[pewex]

How is your experience with the 5-Amino-1MQ so far?
@Sampei as well

When I used it during my contest prep, I have to say I didn't notice any effects from either 750mcg of SLU or 50mg 5-Amino. Recently, I placed another order for 5-Amino, and this time I'll be running it at 150mg/day.

I'm also increasing the SLU dose to 2mg/day to give it one final shot, especially since both are pretty cheap right now. I plan to use the 5-Amino during a "mini cut" once I get too fat in this current push phase, while running the SLU throughout.

 

[AllGoodThings]

I think it's a lot more. I know people who use 30mg+ per day with amazing results.

• Mouse studies often use 5–10 mg/kg daily, orally or via IP injection.
• Based on standard allometric scaling, this translates to approximately:

People have been super conservative with dosing because of price.

The person you quoted said "2-4 g", not mg, so that would be 2000-4000mg they were referring to.

I've only ever tried mcg doses myself, but I'm considering getting some of the 20mg tabs and giving much higher doses a try.

I was doing the injectable for a bit, but found out that, supposedly, it degrades exceptionally quickly in liquid, and needs to be injected immediately after reconstitution. The same was said about MOTS-C early on, and that didn't turn out to be accurate, so who knows. That's one of the frustrating things about these compounds; so little actual data exists on them that we're forced to rely on speculation and anecdotal information to devise our own protocols and experiment with it ourselves. It's also part of the fun, too, I suppose.

 

[AllGoodThings]

When I used it during my contest prep, I have to say I didn't notice any effects from either 750mcg of SLU or 50mg 5-Amino. Recently, I placed another order for 5-Amino, and this time I'll be running it at 150mg/day.

I'm also increasing the SLU dose to 2mg/day to give it one final shot, especially since both are pretty cheap right now. I plan to use the 5-Amino during a "mini cut" once I get too fat in this current push phase, while running the SLU throughout.

Supposedly that's where 5 Amino 1MQ is really supposed to shine too, pre-contest or when you're at single digit bodyfat levels. I have some to try, but I'm easily over 10% at the moment, so it'll have to wait until I start a cut and get low. Have you tried injectable 5 Amino? I've heard it's bioavailability is greatly increased over the oral form, something like 5 fold was the number I recall being thrown around. I picked some of the 50mg up from a source here, and will be using that version. They warned me that it's a very bold orange color, but ensured me that the color had no negative effect on quality or purity. Oddly enough, they also told me their lower concentrations were "normal" (I assume clear?). Thankfully I'm pretty dark, so no concern about getting orange dots on my midsection lol
I also have some injectable slu-pp-332 inbound that I got before learning about it's terrible stability in liquid (see my above post), and plan to use that on addition to the SLU tabs. I'll be interested to hear what you're experience is with thr higher doses.

It's definitely.. Orange

 

[Kralteramon]

Supposedly that's where 5 Amino 1MQ is really supposed to shine too, pre-contest or when you're at single digit bodyfat levels. I have some to try, but I'm easily over 10% at the moment, so it'll have to wait until I start a cut and get low. Have you tried injectable 5 Amino? I've heard it's bioavailability is greatly increased over the oral form, something like 5 fold was the number I recall being thrown around. I picked some of the 50mg up from a source here, and will be using that version. They warned me that it's a very bold orange color, but ensured me that the color had no negative effect on quality or purity. Oddly enough, they also told me their lower concentrations were "normal" (I assume clear?). Thankfully I'm pretty dark, so no concern about getting orange dots on my midsection lol
I also have some injectable slu-pp-332 inbound that I got before learning about it's terrible stability in liquid (see my above post), and plan to use that on addition to the SLU tabs. I'll be interested to hear what you're experience is with thr higher doses.

It's definitely.. Orange
View attachment 339657

That.. looks like carrot juice to me. Let us know when you start hopping around like a rabbit, or craving salads. Did you remove the vial cap/crimp because you were going to pour it over your pasta?

I'm also hopping on SLU PP 20mg when it arrives. Hope the pills from SSA are splitable. Might be a high starter dose otherwise.

In the name of science we sacrifice our health, amen.

 

[AllGoodThings]

That.. looks like carrot juice to me. Let us know when you start hopping around like a rabbit, or craving salads. Did you remove the vial cap/crimp because you were going to pour it over your pasta?

I'm also hopping on SLU PP 20mg when it arrives. Hope the pills from SSA are splitable. Might be a high starter dose otherwise.

In the name of science we sacrifice our health, amen.

That was actually a screenshot from a video ssa sent me as a disclaimer when I asked to order it. They said to be sure I was okay with the color before ordering. Watery pasta sauce or carrot juice definitely describes it well. For what it's worth, the 5 Amino 1MQ capsules I have contain an orange colored powder. I don't think the 20mg tabs are scored, but that's just a guess based on the fact that I have their 250mcg and 1000mcg tabs, and neither of those are. You'd hope they'd do it for the 20mg's, but ease of manufacturing probably means they won't be. Still, a good quality pill cutter should be able to split them fairly well.