Single or Multiple injections per week (Reta)

[Zrom57]

So I know this question has been asked, but I was just wondering if anyone had experienced doing multiple injections per week and had switched to a single injection or vise versa and what your experience with that was?

I just started with a .5mg injection last Monday to see how my body reacted to it and planned on going up to 1mg this week and was just curious on people’s experiences doing 1 dose vs multiple smaller doses in a week.

Thanks for any input!

 

[007R]

I've tried Reta in several ways, and the best way for me to use it is to lose weight twice a week, Monday and Thursday, 2.5mg and 2.5mg, and to gain clean weight three times a week, Monday, Wednesday, and Friday, 0.5mg x 3 times.
If I use a large dose of 5mg, I get severe heartburn and can barely eat.

 

[Eddie.]

I've tried Reta in several ways, and the best way for me to use it is to lose weight twice a week, Monday and Thursday, 2.5mg and 2.5mg, and to gain clean weight three times a week, Monday, Wednesday, and Friday, 0.5mg x 3 times.
If I use a large dose of 5mg, I get severe heartburn and can barely eat.

Me too, until 4mg i was ok, at 6 first 2 weeks were ok too but after it started peaking it messed me up. I was waking up in the middle of the night from puke in my mouth. Now i'm at 2mg and i might bump that to 3 but still unsure.

 

[watchtymeflyyy]

Sema is shit compared to Reta

That was my point

 

[sterlingschrute]

I was very sensitive to sides on sema, so that soured my approach to reta. I am doing reta 2x weekly to split the dose. In my mind, this reduces the chance for unexpected sides to pop up.

And...I've noticed no outrageous sides in the past 4 weeks. Just reduction of food noise and increased libido (may be the reta or may be the weight loss). \

The weight is slowly dropping (I am forcing food down to limit to 2lbs/week loss). I am seeing changes in the mirror, too. I haven't really experienced the increased RHR, which is odd. Maybe 5 points standard deviation.

It probably doesn't matter if you do E5D 1 dose or E3D .5 dose. Just experiment both ways and/or do what is most convenient for your schedule.

 

[sterlingschrute]

Why is everyone now starting with this .5mg or 1mg ?

The pharma protocol calls for 2mgs starting. I can’t see ppl getting benefits from literally a qtr of the prescribed starting dose.

You are right that it may not help, but it also certainly won't hurt to titrate slower. Some people are incredibly sensitive to GLP sides and slow titration gives 1) our bodies more time to adapt to the new stimuli and 2) us a chance to take note of sides before jumping straight in to the clinical starting dose.

 

[sterlingschrute]

I also know people who use GLPs and ignore the warnings about what to eat and what not to eat. When I first started on Tirz I learned real fast I was going to have to eat healthier and smaller meals. Or else I would pay for my mistakes.

Learned that with sema the hard way. Reta has been fantastic, though. Food noise is decreased, but I can 100% push through the mental barrier to hit my daily cals/protein #s. If I tried that with sema back in the day, I would've been handcuffed to the bathroom for hours.

 

[Infernalmango]

I’m currently up to 6mg of Reta. Had appetite suppression in the middle of this run, but now I feel like I could eat enough to call it a bulk. Still pretty easy to just be strict, but not how I felt when running tirz. Couldn’t ever push more than 2k calories on 5mg of tirz. Not sure if Iv just been in a deficit too long, or I need to up the Reta to 8mg. I’m usually a fan of using the lowest effective dose for as long as possible, so we’ll ride it out until I find myself snacking a bit too much.

 

[livingjules]

This was my thought process. Rather start off slow and build up in smaller increments than have my appetite be destroyed and be super nauseous day 1.

This was my experience on Tirzepatide. Completely destroyed my appetite and I couldn't eat at all = increased lethargy and overall just feeling crap.

Smaller doses split twice per week with incremental increases was the sweet spot for me.

Going to try Reta as soon as my order arrives and will be following the same protocol.

 

[Oldhand]

Just want to share my experience since this is a great thread with a lot of info in it already…

The last half of my first week on Reta was rough. I took 1 mg on Monday and 1 mg on Thursday. Saturday and Sunday I had had like I’ve never had gas before. When I felt like I had to burp it would just come out. Violent, jet propelled burps… this is not like me.

I didn’t realize how much this stuff slows down digestion. I had two bowls of high fiber cereal and I think this is what did it. The cereal sat in my stomach and just gassed.

I’ve not had this problem since and I’ve worked up to 8mg a week. While some of it may be that my body has adjusted to the Reta, I think the main reason is diet related…. Be careful what you eat. If you do eat something slow digesting, eat about 1/2 of what you would normally.

 

[Untold2101]

So I know this question has been asked, but I was just wondering if anyone had experienced doing multiple injections per week and had switched to a single injection or vise versa and what your experience with that was?

I just started with a .5mg injection last Monday to see how my body reacted to it and planned on going up to 1mg this week and was just curious on people’s experiences doing 1 dose vs multiple smaller doses in a week.

Thanks for any input!

Once a week with Reta, that's also way too low of a dose. Don't compare it to Sema when dosing assuming you may have started there.

 

[Untold2101]

Just want to share my experience since this is a great thread with a lot of info in it already…

The last half of my first week on Reta was rough. I took 1 mg on Monday and 1 mg on Thursday. Saturday and Sunday I had had like I’ve never had gas before. When I felt like I had to burp it would just come out. Violent, jet propelled burps… this is not like me.

I didn’t realize how much this stuff slows down digestion. I had two bowls of high fiber cereal and I think this is what did it. The cereal sat in my stomach and just gassed.

I’ve not had this problem since and I’ve worked up to 8mg a week. While some of it may be that my body has adjusted to the Reta, I think the main reason is diet related…. Be careful what you eat. If you do eat something slow digesting, eat about 1/2 of what you would normally.

Ginger root extract helps with all the GLP-1's, speeds up gastric motility. You still have the reduced appetitie and better glucose control. For anybody other than people with super fast gastric emptying, you just wind up getting too slow down there and fermenting everything.

 

[nerdwithmuscles]

I have been doing 3mg (1mg 3x per week M/W/F) for about a month now. I started at 1.5 (.75 2x), then 2mg (split over 3x M/W/F), and all the way up to 4 (also split 3x). 4mg was too much appetite suppression and some digestive issues (some acid reflux).

This has all been in my 8 weeks post competition. 3mg a week split up has been good for keeping hunger in check post show while still being able to push up some calories. I did one week with 1 dose just to see how it felt and it was too much at once for me.

 

[nerdwithmuscles]

I have been doing 3mg (1mg 3x per week M/W/F) for about a month now. I started at 1.5 (.75 2x), then 2mg (split over 3x M/W/F), and all the way up to 4 (also split 3x). 4mg was too much appetite suppression and some digestive issues (some acid reflux).

This has all been in my 8 weeks post competition. 3mg a week split up has been good for keeping hunger in check post show while still being able to push up some calories. I did one week with 1 dose just to see how it felt and it was too much at once for me.

Also forgot to mention how much is has helped my blood sugar. My fasting BG had been creeping up over the last few months as I have been pushing GH and it went from around 100 down to 70s. Today was 69. I think it will be a great addition to my growth phase to keep me insulin resistant.

 

[phenominal34]

This was my experience on Tirzepatide. Completely destroyed my appetite and I couldn't eat at all = increased lethargy and overall just feeling crap.

Smaller doses split twice per week with incremental increases was the sweet spot for me.

Going to try Reta as soon as my order arrives and will be following the same protocol.

It’s because you have to eat or have liquid nutrients. You’re starving yourself and wonder why you feel crappy or lethargic

 

[Avies48]

How has everyone’s blood sugar been? With and without gh…? I guess this would allow u to go up or even use gh moreso and not worry as much about blood sugar?

 

[Ghoul]

How has everyone’s blood sugar been? With and without gh…? I guess this would allow u to go up or even use gh moreso and not worry as much about blood sugar?

A number of members use GLPs to counteract GH insulin resistance.

4iu took morning fasted glucose from 90 to 110. Once a week Tirz brought it down to 85 so I could raise GH dose if I wanted to and keep glucose in range.

 

[bananafeet]

My 5 cents:

Micro dosing GLP1 drugs will allow you to take more mg per week which will allow you to shut down your GI tract more.

The beauty of the once per week dosing protocol is your stomach slowly comes back online on day 5. If you dose every 3.5 days your stomach is permanently shut down (because it has the strongest affinity for GLP1-RAs).

Yes you get less accute side effects by micro dosing BUT you can push the dose much higher to a level that you couldn't handle in a weekly shot.

I also firmly believe a certain minimum dosing is required for the full effect. Micro dosing might not allow a peak high enough to hit the parts of the body weakly receptive to GLP1-RA and you'll just end up smashing your pancreas and stomach 24/7.

 

[Ateam2023]

My 5 cents:

Micro dosing GLP1 drugs will allow you to take more mg per week which will allow you to shut down your GI tract more.

The beauty of the once per week dosing protocol is your stomach slowly comes back online on day 5. If you dose every 3.5 days your stomach is permanently shut down (because it has the strongest affinity for GLP1-RAs).

Yes you get less accute side effects by micro dosing BUT you can push the dose much higher to a level that you couldn't handle in a weekly shot.

I also firmly believe a certain minimum dosing is required for the full effect. Micro dosing might not allow a peak high enough to hit the parts of the body weakly receptive to GLP1-RA and you'll just end up smashing your pancreas and stomach 24/7.

i guess that would depend on which glp you decide, They all seem to have a "different " effect from research and from anecdotal experiences ,,

 

[bananafeet]

i guess that would depend on which glp you decide, They all seem to have a "different " effect from research and from anecdotal experiences ,,

No I don't think so. The newer ones still mainly bind to GLP1. If they didn't the glucose they release would make diabetes worse.

I've tried sema and tirzepatide and they basically work the same. Tirz has less of an profound effect on my stomach than sema does - less reflux etc

 

[bananafeet]

I don't know how to interpret the data from this study showing binding affinity:

https://cf-ecom.eurofinsdiscoveryservices.com/wp-content/uploads/2024/09/Eurofins-Discovery-GLP-1-GIP-Glucagon-receptor-binding-and-functional-assays-Poster-EM-GPCR-meeting-2024.pdf?utm_source=chatgpt.com

Seems to me that no matter the dose you take GLP1 will get hammered. But maybe you lose out of the other receptors unless the dose is high enough.

I need someone who actually knows science - not me.