I’ve used compounded tirz (first) and ugl tirz (after I found out the prices). I only felt slightly nauseous in the very first week of the compounded version. My body got used to it. The ugl tirz, even with legit bac water, gives me a little red blotch in the injection site. The compounded tirz never game me a blotch. But it’s small and I can live with it. All the other effects are the same for me.
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ExogenousDan
Member
Can’t say I’ve experienced a little red blotch from ugl tirzepatide. Who’s tirz was you using?
ExogenousDan
Member
I have QSC and haven’t experienced that to be honest
Ghoul
Member
Site reactions are usually an immune response (subQ tissue has the strongest defenses), but there's a lot of variability from one individual to another.
It happens in pharma too, but there's all kinds of unknown shit, "uncharacterized contaminants", in UGL so it's more likely to trigger it.
Quick update on SSA Tirz 30mg - second week at 7.5mg per week, and it’s working like a charm. Appetite is non-existent, everything’s on point. Previously used Tirz from GA, and that one was solid too - no complaints on quality.
Now just waiting on HGH purity test results to see if there’s any dimmer lurking in there. If it’s clean, I’ll order. If not, might have to give Lobster HGH a shot - because if I’m injecting something, it might as well have a fancy seafood name. As for Q, I don’t think he’s coming back, which is a loss for the community, but at this point, it is what it is.
Now just waiting on HGH purity test results to see if there’s any dimmer lurking in there. If it’s clean, I’ll order. If not, might have to give Lobster HGH a shot - because if I’m injecting something, it might as well have a fancy seafood name. As for Q, I don’t think he’s coming back, which is a loss for the community, but at this point, it is what it is.
As people said, it’s an individual reaction. I’m not blaming QSC.
ExogenousDan
Member
Ah I see. Makes sense cheers
bigMoJo
Member
Just curious... are you guys filtering the tirz at some point prior to injection?
I filter after reconstituting for a family member, who's skin (and just about everything else) is super sensitive, and there are no adverse reaponse at the injection site. All filtered tirz goes into a fresh vial and sits in the fridge for about a month.
ExogenousDan
Member
I haven’t bothered filtering the tirz. Probably should filter most but haven’t bothered with that precaution
Ghoul
Member
I did the same when using UGL Tirz. It seemed to become more effective, at the same dose, incrementally, over the first month after I started doing it. As if I increased the dose slightly.
That's entirely a feels report, but it does align with the widely understood dynamic of reduced immunogenicity (in this case by removing aggregated proteins and other particulates), improving the effectiveness of a peptide / protein drug.
Happen to just be reading this patent that sums it up nicely (instead of filtering them out, it uses high pressure to break aggregates up back into their original individual peptides)
"The invention achieves these goals by evaluating therapeutic protein preparations for subvisible protein particulates, which can contribute significantly to the overall immunogenic potential of the protein preparation. Further, by maintaining the content of such subvisible protein particulates to below an immunogenic threshold level, the resulting pharmaceutical composition is less likely to result in a loss of tolerance (e.g., upon repeated administration), thereby improving both the safety and efficacy profile of the therapeutic."
EP2600843A2 - Therapeutic protein compositions having reduced immunogenicity and/or improved efficacy - Google Patents
The present invention provides methods for reducing and/or evaluating the immunogenic potential of a therapeutic protein preparation. The present invention further provides pharmaceutical compositions of therapeutic proteins and methods of treatment with the same, the compositions having low...
patents.google.com
bigMoJo
Member
That was not nice @Ghoul
That was like one of those long internet, try-to-sell-you something pages that keeps going on about, "the product this," and, "the product that," and, "this is what it is," but, "the product can also..."
Man! Get to the product already!
You have to keep reading, or just scroll to the bottom of the page to get a link to the product and price.
That was F'd up ghoul... go ahead and have your laugh... I"m not going to forget you did this today
Anyway, "High Pressure Tube or Container" or whatever. IDK, I was lost.
Did you catch any images of the "invention?"
Spaceman Spiff
Subscriber
What dose of the compounded version?
Ghoul
Member
That was not nice @Ghoul
That was like one of those long internet, try-to-sell-you something pages that keeps going on about, "the product this," and, "the product that," and, "this is what it is," but, "the product can also..."
Man! Get to the product already!
You have to keep reading, or just scroll to the bottom of the page to get a link to the product and price.
That was F'd up ghoul... go ahead and have your laugh... I"m not going to forget you did this today
Anyway, "High Pressure Tube or Container" or whatever. IDK, I was lost.
Did you catch any images of the "invention?"
LOL, sorry no. This is a process for manufacturers, not end users, it just had a nice little description of the problem.
Didn't mean to get you excited.
Closest we've got to do what this thing does is a filter
No, no filtering
The compounded I did the classic 2.5 for 4 weeks, increased to 5 for another 4 and got 7.5 max. By then I had lost all the fat I wanted to. The ugl Tirz I’m using as sort of maintenance here and there, 2.5 dosage.
Ghoul
Member
As long as you don't pull out a microscope it's like injecting crystal pure Chinese mountain spring water.
Hmm, that would explain a lot. Maybe these partial orders are a way to clear the last of their inventory without advertising that they only have a few things left in stock.
I gotta say, it doesn't look too good for our chinese fellas at the moment.
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