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[roofer22]

I put in an order to see how things are now that big brothers gone. Not liking what I read about the semaglutide since I ordered a few kits. They have a big opportunity here if they want it and can quit making mistakes.

 

[magnuss88]

It seems like they’re going the other way (less engaging). What's the deal with needing a phone number now for their discord channel?

Is adding your number that big a deal? I havent done it yet because I get why it’s safer not to. But I’m wondering if I’m just being overly cautious.

 

[Letits now]

It seems like one of the things that Q was able to do very well is deliver on a large scale. It appears, as the other shops have increased business, they are struggling. Or their pre-existing issues are becoming more apparent. I thought SSA would be the heir apparent, and they still could be, but they seem to be shitting the bed right now.

I’m waiting on some 24 iu to get delivered and see if it tests well since Q was my go to.

 

[thecmorgan]

I put in an order to see how things are now that big brothers gone. Not liking what I read about the semaglutide since I ordered a few kits. They have a big opportunity here if they want it and can quit making mistakes.

Which sema kits did you order? I wonder if the sema kits you get will match the colors that got tested by ssa. Last month I sent a couple of messages about current stock and if any of it matches the cap color that was tested and got no reply. I only bought 1 kit and have 5 vials left so I figure its a waste of money to send one of those to jano, especially if ssa is shipping a different batch now.

 

[roofer22]

Which sema kits did you order? I wonder if the sema kits you get will match the colors that got tested by ssa. Last month I sent a couple of messages about current stock and if any of it matches the cap color that was tested and got no reply. I only bought 1 kit and have 5 vials left so I figure its a waste of money to send one of those to jano, especially if ssa is shipping a different batch now.

10 mg. Not sure about caps yet.

 

[flipup7]

Pretty good?

2.5% impurities, at the very least (there are types of impurities that aren't readily detected with this testing method), none of which are characterized (in other words, they aren't specifically identified, understandable, as that's an expense process).

Those impurities could easily be responsible for inducing high levels of immunogenicity, triggering antibody formation that reduces, or completely eliminates, the efficacy of Semaglutide. Like the effects of a vaccine, this immunogenicity can be short lived, or lifelong.

Sound far fetched?

"As emphasized in the FDA guidelines, peptide-related impurities must be strictly controlled, and any new peptide-related impurity identified at levels higher than 0.5% must be evaluated for immunogenicity. This is critical, as demonstrated by the clinical trial discontinuation of taspoglutide due to reported anaphylaxis and similar reactions observed with exenatide administration.

Taspoglutide, despite having an amino acid sequence nearly identical to Semaglutide and native GLP-1, exhibited significantly different side effects regarding immune response."

Semaglutide Impurity Analysis

Are any of those impurities Taspoglutide? Or something worse than Taspoglutide? It's nearly identical to Semaglutide so a minuscule error in synthesis could easily produce it and it's very difficult to remove through purification.

Here's a chart of the immune reaction levels of pharma GLP class drugs on the left, and two compounded, "legal UGL" GLP drugs, Sema and Tirz, on the right. They're as much as 2000x higher than the pharma products, and likely better than what we're getting from UGL. Also notice immunogenicity is reduced by as much as 80% after filtering.

View attachment 316018

It is not out of the realm of possibility that someone becomes a partial or complete "non-responder" to Semaglutide, potentially for life, after exposure to certain Semaglutide related impurities.

No arguments here, ill probably just dotch this kit given the purity and bad user reports, these concerns totally makes sense.

The part i dont get is how a user like @thecmorgan who was new to Sema could start off with no feel from presumably the same batch.

Even given immunogenicity and purity concerns, it would take some time, even just a few weeks to develop, right?

 

[thecmorgan]

Is adding your number that big a deal? I havent done it yet because I get why it’s safer not to. But I’m wondering if I’m just being overly cautious.

I'm with you in being overly cautious. I just thought it was odd when I logged into discord last week that their channel was the only one asking for a phone number. I think you only need to put in a number if you want to post. Some people don't care about giving their cell phone numbers out, some do. I guess it depends on your personal opsec. If you do care, you can try some of the free apps/websites offer numbers for text messages, but a lot of times those wont work for verifications.

 

[Ghoul]

No arguments here, ill probably just dotch this kit given the purity and bad user reports, these concerns totally makes sense.

The part i dont get is how a user like @thecmorgan who was new to Sema could start off with no feel from presumably the same batch.

Even given immunogenicity and purity concerns, it would take some time, even just a few weeks to develop, right?

He's not a new GLP user. Was using UGL Tirz prior to Sema.

 

[piggy_nui]

It seems like one of the things that Q was able to do very well is deliver on a large scale. It appears, as the other shops have increased business, they are struggling. Or their pre-existing issues are becoming more apparent. I thought SSA would be the heir apparent, and they still could be, but they seem to be shitting the bed right now.

I’m waiting on some 24 iu to get delivered and see if it tests well since Q was my go to.

Would you share the results with us? I’m waiting for testing to put an order, they promised the tests for the 24 and 36 IU some time ago but they never come up with those.

 

[thecmorgan]

No arguments here, ill probably just dotch this kit given the purity and bad user reports, these concerns totally makes sense.

The part i dont get is how a user like @thecmorgan who was new to Sema could start off with no feel from presumably the same batch.

Even given immunogenicity and purity concerns, it would take some time, even just a few weeks to develop, right?

I did switch from 12.5mg qsc tirz to ssa's sema. With a 2 week break between the two. So I figured I would need to get to 1.7mg or 2.4mg for sema to work.
The tirz worked great. I started that at 1250 and increased every 5 to 6 weeks. I could just be a non responder to sema or maybe its a bad kit.

 

[Ghoul]

I did switch from 12.5mg qsc tirz to ssa's sema. With a 2 week break between the two. So I figured I would need to get to 1.7mg or 2.4mg for sema to work.
The tirz worked great. I started that at 1250 and increased every 5 to 6 weeks. I could just be a non responder to sema or maybe its a bad kit.

Why did you switch to Sema?

 

[Grey Spartan]

2.4mg Sema is a huge dose. Everyone I know taking near that dose, man or woman, "feels" strong sides with that much. I can only imagine what 5mg would do.

I just upped my Sema dose to 2.5mg this week and it is the first time I have felt any kind of appetite suppression. I do get the other benefits from it like lower fasted glucose levels and not thinking about food.

 

[Letits now]

Would you share the results with us? I’m waiting for testing to put an order, they promised the tests for the 24 and 36 IU some time ago but they never come up with those.

I can give a thumbs up or thumbs down.
It’s going to be a while. Ray may have a test posted before mine is done. But we need to do our own tests anyway.

 

[piggy_nui]

I can give a thumbs up or thumbs down.
It’s going to be a while.

Thanks, that suffices!!!

 

[Ghoul]

I just upped my Sema dose to 2.5mg this week and it is the first time I have felt any kind of appetite suppression. I do get the other benefits from it like lower fasted glucose levels and not thinking about food.

Were you using another GLP before?

 

[Grey Spartan]

Were you using another GLP before?

Nope only Sema.

 

[thecmorgan]

Why did you switch to Sema?

My wife....She has allergic reactions (injection site swelling/itch) to tirz and has been using skye peptides sema with good results. And I figured we could save some money buying a kit of 20mg for $120 vs 1 10mg vial for $120. I am the guinea pig for any new batches of peptides so I switched to sema when I ran out of tirz to test the "feelz" before giving it to her.

 

[bigMoJo]

I just upped my Sema dose to 2.5mg this week and it is the first time I have felt any kind of appetite suppression. I do get the other benefits from it like lower fasted glucose levels and not thinking about food.

Are you splitting the "appetite suppression" and "not thinking about food" into two separate benefits?

My family member switched from compound pharmacy Sema to UGL Tirz. First 3 months Sema, got to .5mg, a little appetite suppression, but strong bowel sides. Month 4, switched to Tirz 5mg... same appetite, but no sides. Month 5, upped to 6mg (not Pharma recommened dosage), and now really feels the appetite suppression and a little nausea if overeating.

 

[Blahblahblacksheet]

My wife....She has allergic reactions (injection site swelling/itch) to tirz and has been using skye peptides sema with good results. And I figured we could save some money buying a kit of 20mg for $120 vs 1 10mg vial for $120. I am the guinea pig for any new batches of peptides so I switched to sema when I ran out of tirz to test the "feelz" before giving it to her.

I found the skin reaction is due to the bac water, not the peps, so maybe play around with the ph by trying some other varieties.

 

[Ghoul]

I found the skin reaction is due to the bac water, not the peps, so maybe play around with the ph by trying some other varieties.

Agreed, especially the lumps. It's not a thing with pharma tirz. Then again anything could be in a UGL peptide so who knows what's causing the reaction.

.5ml volume per tirz dose can often help mitigate this issue often. More concentrated protein solutions illicit stronger immune responses than more dilute ones.