Sigma Audley Inc. - Your source for peptides, ancillaries, AAS, and more!

[Mongo966]

I sent some off for testing because of these reports. It appears to be the same batch. Peptide Test and Jano (just ran lcms to try to identify the source of degradation) both came back pretty good so I'm stumped as to why.

Thanks. Maybe it's other factors I'm not taking into account. I'm not about to flat-out accuse them of ripping me off, it's just seems strange to me that I'm not feeling sick or averse to this giant bowl of smartfood I've poured for myself. I'll give it another few weeks and see how the feels are feeling.

 

[flipup7]

Thanks. Maybe it's other factors I'm not taking into account. I'm not about to flat-out accuse them of ripping me off, it's just seems strange to me that I'm not feeling sick or averse to this giant bowl of smartfood I've poured for myself. I'll give it another few weeks and see how the feels are feeling.

I was surprised at the results given multiple reports of no feels.

That said there have been a ton of 0 peptides recently. Jano has mentioned seeing more BS peptides in the last few months. Definitely worth testing if you can.

 

[bigMoJo]

Novo Nordisk is trialing 7.2mg now . News Details But yes current official guidelines for weight loss are 2.4mg with wegovy.

2.4mg Sema is a huge dose. Everyone I know taking near that dose, man or woman, "feels" strong sides with that much. I can only imagine what 5mg would do.

 

[damian90k]

update as promised: order placed early last week. tracking provided over the weekend. the number is officially live & arrived to shipping partner.

damn it, i’m going to be out of town all week too. not only does it seem legit and going to land, it’s a possibility that SSA shipped too fast.

Good for you. I'm still waiting for my powder's that they forget to add before CNY and promise to reship after CNY.

 

[Ghoul]

I sent some off for testing because of these reports. It appears to be the same batch. Peptide Test and Jano (just ran lcms to try to identify the source of degradation) both came back pretty good so I'm stumped as to why.

Pretty good?

2.5% impurities, at the very least (there are types of impurities that aren't readily detected with this testing method), none of which are characterized (in other words, they aren't specifically identified, understandable, as that's an expense process).

Those impurities could easily be responsible for inducing high levels of immunogenicity, triggering antibody formation that reduces, or completely eliminates, the efficacy of Semaglutide. Like the effects of a vaccine, this immunogenicity can be short lived, or lifelong.

Sound far fetched?

"As emphasized in the FDA guidelines, peptide-related impurities must be strictly controlled, and any new peptide-related impurity identified at levels higher than 0.5% must be evaluated for immunogenicity. This is critical, as demonstrated by the clinical trial discontinuation of taspoglutide due to reported anaphylaxis and similar reactions observed with exenatide administration.

Taspoglutide, despite having an amino acid sequence nearly identical to Semaglutide and native GLP-1, exhibited significantly different side effects regarding immune response."

Semaglutide Impurity Analysis

Are any of those impurities Taspoglutide? Or something worse than Taspoglutide? It's nearly identical to Semaglutide so a minuscule error in synthesis could easily produce it and it's very difficult to remove through purification.

Here's a chart of the immune reaction levels of pharma GLP class drugs on the left, and two compounded, "legal UGL" GLP drugs, Sema and Tirz, on the right. They're as much as 2000x higher than the pharma products, and likely better than what we're getting from UGL. Also notice immunogenicity is reduced by as much as 80% after filtering.



It is not out of the realm of possibility that someone becomes a partial or complete "non-responder" to Semaglutide, potentially for life, after exposure to certain Semaglutide related impurities.

 

[HUGE McBIGLARGE]

immunogenicity is reduced by as much as 80% after filtering.

Still recommend as much BAC as possible through a filter that is 0.22um, PES, hydrophilic, non-charged?

 

[Ghoul]

Still recommend as much BAC as possible through a filter that is 0.22um, PES, hydrophilic, non-charged?

Those simple steps are the best we can do to reduce the risk of immunogenicity when dealing with UGL peptides that have charachteristics which are largely invisible to us via these crude "purity" tests.

There is more that can reduce the risk further, but those steps are the low hanging fruit, easy, almost effortless, and will have the biggest impact.

You can see the FDA, while not endorsing compounded GLPs, made a point of showing how much of a difference .2um filtration made towards lowering immunogenicity.

People using pharma GLPs like Ozempic don't develop these issues of it no longer working for them, while it's common with users of the UGL copies.

People better wake the fuck up, peptides are not like other drugs. Needlessly destroying your ability to respond to these could mean losing access to the benefits of the most important class of medicine in our lifetime.

 

[HUGE McBIGLARGE]

Those simple steps are the best we can do to reduce the risk of immunogenicity when dealing with UGL peptides that have charachteristics which are largely invisible to us via these crude "purity" tests.

There is more that can reduce the risk further, but those steps are the low hanging fruit, easy, almost effortless, and will have the biggest impact.

You can see the FDA, while not endorsing compounded GLPs, made a point of showing how much of a difference .2um filtration made towards lowering immunogenicity.

People using pharma GLPs like Ozempic don't develop these issues of it no longer working for them, while it's common with UGL users if the same compounds.

I’ve seen you recommend backfilling an injection syringe with a filtered peptide that is filtered again, and then reusing the filter for several days in a row; storing the filter in a box.

Wouldn’t leaving some of the peptide stagnant in the filter, as well as exposed to air, increase your risk more than just filtering the whole peptide once and using it without filtering again?

 

[Ghoul]

I’ve seen you recommend backfilling an injection syringe with a filtered peptide, and then reusing the filter for several days in a row; storing the filter in a box.

Wouldn’t leaving some of the peptide stagnant in the filter, as well as exposed to air, increase your risk more than just filtering the whole peptide once and using it without filtering again?

That's a fair question, and I certainly don't have all the answers, just making the best choices I can on the balance of probabilities as I see them. I welcome discussion on this so by putting our heads together, we can continually improve the risk reduction.

Also, most steps to try and reduce immunogenicity are less than perfect, and may impart some additional risk while also reducing it. The question is whether it helps more than hinders.

The Liquid/Air interface is a factor in generating aggregates, which are a primary cause of immunogenicity.

I see it like this.

When in the vial, the entire large surface area of the top layer of the liquid is exposed to air.

While in a filled syringe, with an attached liquid filled filter+needle, there will be continuous fluid present all the way to the tip of the needle, only exposing that very small area where air meets liquid inside the needle shaft. It's really the same thing as is happening in a multi-dose injection pen.

And yes backfilling is certainly less than ideal, but as I pointed out before, done quickly with some common sense, it's no worse than filling a syringe from an ampule with its top cracked off, or even having to connect a luer lock syringe and needle out in the open exposed to unsterile air.

 

[HUGE McBIGLARGE]

That's a fair question, and I certainly don't have all the answers, just making the best choices I can on the balance of probabilities as I see them. I welcome discussion on this so by putting our heads together, we can continually improve the risk reduction.

Also, most steps to try and reduce immunogenicity are less than perfect, and may impart some additional risk while also reducing it. The question is whether it helps more than hinders.

The Liquid/Air interface is a factor in generating aggregates, which are a primary cause of immunogenicity.

I see it like this.

When in the vial, the entire large surface area of the top layer of the liquid is exposed to air.

While in a filled syringe, with an attached liquid filled filter+needle, there will be continuous fluid present all the way to the tip of the needle, only exposing that very small area where air meets liquid inside the needle shaft. It's really the same thing as is happening in a multi-dose injection pen.

And yes backfilling is certainly less than ideal, but as I pointed out before, done quickly with some common sense, it's no worse than filling a syringe from an ampule with its top cracked off, or even having to connect a luer lock syringe and needle out in the open exposed to unsterile air.

Thanks for the feedback, man. I get through my peptides in a few days, so I don’t think I’ll bother filtering it twice.

 

[Treegles]

I used to really like this vendor but after receiving a partial order and then seeing it continue to happen to others, it has swiftly moved to the bottom of the list. I'll give them credit for instantly refunding me, that's great. But the fact that this seems be happening more often than not means that this is intentional. Someone in charge made the baffling decision that this was "the move" and are actively driving their reputation into the ground.

I'll also say, the forum rep might need to change. There's no personality. I can't even remember their name. That used to be a good thing but right now it's not. Address the community that patronizes you and make us believe you are aware of the issue and rectifying it. One liner "contact your rep" and "here's the new price list" posts aren't cutting it anymore.

 

[bigtom343]

I'll also say, the forum rep might need to change. There's no personality. I can't even remember their name. That used to be a good thing but right now it's not. Address the community that patronizes you and make us believe you are aware of the issue and rectifying it. One liner "contact your rep" and "here's the new price list" posts aren't cutting it anymore.

So your asking for Tracy to jump on SSA and tell you to eat dog shit

 

[ovrdooze]

first order (containing oils too) :
ordered and paid on the 5th
payment confirmed on the 6th
live tracing received today (11th)
sales rep is Yoya
Can't say anything wrong so far, just to have some positive feedback in the sea of negativity here, hopefully it's a sign of service improvement

 

[Trenbolonetax]

I used to really like this vendor but after receiving a partial order and then seeing it continue to happen to others, it has swiftly moved to the bottom of the list. I'll give them credit for instantly refunding me, that's great. But the fact that this seems be happening more often than not means that this is intentional. Someone in charge made the baffling decision that this was "the move" and are actively driving their reputation into the ground.

I'll also say, the forum rep might need to change. There's no personality. I can't even remember their name. That used to be a good thing but right now it's not. Address the community that patronizes you and make us believe you are aware of the issue and rectifying it. One liner "contact your rep" and "here's the new price list" posts aren't cutting it anymore.

Need more big dick Tracy energy out of SSA

 

[Juiced_lizard]

Need more big dick Tracy energy out of SSA

I call that tren Tracy

Eat dog shit…..alone

 

[Treegles]

So your asking for Tracy to jump on SSA and tell you to eat dog shit

No, I would have typed that if I meant to say it. I enjoyed the soulless robot business man style but now that we've decided to start making Marcus and Alan type of mistakes that approach just doesn't work anymore. They gotta stop ignoring shit and talk to their customers.

 

[HUGE McBIGLARGE]

Anyone received orders placed since CNY started?

 

[thecmorgan]

I sent some off for testing because of these reports. It appears to be the same batch. Peptide Test and Jano (just ran lcms to try to identify the source of degradation) both came back pretty good so I'm stumped as to why.

Thank you for sharing your test results. I don't know what the deal is. The last two tests ssa had posted was 20.32mg + purity of 99.757% and 21.48mg + purity 99.619. Your test showed 24.56mg + purity 97.511%. I don't know a lot about testing but I assume ssa sample was fresh off the line, so it would test higher in purity. What I don't understand is how your sample tested 2% lower in purity but tested higher in mg by 14% or 21% depending on which ssa test your compare. I calculate my shots based on 20mg in vial, using fresh 3ml Hospira bac. Using your test results of 24.56mg my 5mg shot would be just over 6mg. I had two vials so far with zero vacuum, so maybe I just got a batch that is severely degraded?

 

[thecmorgan]

No, I would have typed that if I meant to say it. I enjoyed the soulless robot business man style but now that we've decided to start making Marcus and Alan type of mistakes that approach just doesn't work anymore. They gotta stop ignoring shit and talk to their customers.

It seems like their going the other way (less engaging). What's the deal with needing a phone number now for their discord channel?

 

[HUGE McBIGLARGE]

What's the deal with needing a phone number now for their discord channel?

I thought that was just discord in general lol