Retatrutide increased fasted BG?

[mrsloppyboo]

I am currently on week 3 of my push phase. Coming out of a 3 week insanely aggressive cut. (Cruised for 4 weeks).

Used retatrutide to cut. Got diced. Still on Retatrutide on my push phase to maintain insulin sensitivity.

Reta dose is 2mg weekly

My fasted BG is consistently in the mid 90s. 94 most mornings. Why is it so high? After my last cut and during my last push phase my fasted BG was in the 60s and never surpassed 80s even on 12iu GH.

Currently I am only running 6iu GH for the past 2.5 weeks. 4iu daily was what I ran for 4 weeks for my cruise.

I have also developed allodynia. My skin is painful to the touch and even taking a shirt off hurts like hell. Any remedies to this?

 

[ascending0roids]

I am currently on week 3 of my push phase. Coming out of a 3 week insanely aggressive cut. (Cruised for 4 weeks).

Used retatrutide to cut. Got diced. Still on Retatrutide on my push phase to maintain insulin sensitivity.

Reta dose is 2mg weekly

My fasted BG is consistently in the mid 90s. 94 most mornings. Why is it so high? After my last cut and during my last push phase my fasted BG was in the 60s and never surpassed 80s even on 12iu GH.

Currently I am only running 6iu GH for the past 2.5 weeks. 4iu daily was what I ran for 4 weeks for my cruise.

I have also developed allodynia. My skin is painful to the touch and even taking a shirt off hurts like hell. Any remedies to this?

wtf bro i think im developing mild allodynia too being on reta and cagri a few days ive noticed my skin being more sensitive especially my legs and even fans make my skin tingle weirdly

 

[Ghoul]

When blood sugar rises too high, pancreatic BETA cells release INSULIN to get muscles and other tissues to absorb the excess.

When blood sugar drops too low pancreatic ALPHA cells release GLUCAGON to get the liver to dump sugar into the blood so you have enough energy to survive.

Reta’s “magic” ingredient, GLUCAGON, continuously stimulates the liver to produce and release sugar into your blood.

This helps burn off a little fat (especially liver fat), but it also raises your glucose levels continuously.

Tirz is the best of the 3 big GLP drugs for glucose control, making it, in my opinion, the best for pairing with rHGH.

Skin sensitivity sides are fairly common with Reta (Rarely it can happen with Sema and Tirz too), but often clear up after a few weeks or months.

 

[RockyP]

Interesting. Same source / batch of reta? I experienced improved glucose in Reta compared to Tirz but everyone is a little different.

Also, have you pulled peripheral bloods or are these all finger sticks? Might be a good idea to get a 12 hour fast in and then get a peripheral blood draw.

 

[Ghoul]

Interesting. Same source / batch of reta? I experienced improved glucose in Reta compared to Tirz but everyone is a little different.

Also, have you pulled peripheral bloods or are these all finger sticks? Might be a good idea to get a 12 hour fast in and then get a peripheral blood draw.

You’re the outlier in this case, since the trials show less glucose lowering with Reta than Tirz too. It’s dose dependent though, since GLP-1 is still a component of Reta, improving insulin response and bringing FBG down at the same time it’s stimulating the liver to dump sugar into your blood.

You may respond more strongly to the GLP part of Reta, your liver may be less efficient at producing glucose, or it may be less fatty than OPs so not as much raw material for glycigenisis.

 

[ascending0roids]

When blood sugar rises too high, pancreatic BETA cells release INSULIN to get muscles and other tissues to absorb the excess.

When blood sugar drops too low pancreatic ALPHA cells release GLUCAGON to get the liver to dump sugar into the blood so you have enough energy to survive.

Reta’s “magic” ingredient, GLUCAGON, continuously stimulates the liver to produce and release sugar into your blood.

This helps burn off a little fat (especially liver fat), but it also raises your glucose levels continuously.

Tirz is the best of the 3 big GLP drugs for glucose control, making it, in my opinion, the best for pairing with rHGH.

Skin sensitivity sides are fairly common with Reta (Rarely it can happen with Sema and Tirz too), but often clear up after a few weeks or months.

thats interesting so if I were to use reta year round id eventually just have the skin sens go away

 

[RockyP]

You’re the outlier in this case, since the trials show less glucose lowering with Reta than Tirz too. It’s dose dependent though, since GLP-1 is still a component of Reta, improving insulin response and bringing FBG down at the same time it’s stimulating the liver to dump sugar into your blood.

You may respond more strongly to the GLP part of Reta, your liver may be less efficient at producing glucose, or it may be less fatty than OPs so not as much raw material for glycigenisis.

Also possible that my sugar was lower just because I’d leaned out so much from point A to B when I drew the sets of labs. Meaning that if I’d stayed on tirz the labs would be just as good 3 months on. However in terms of dose dependent effect I wasn’t not able to tolerate more than 5 mg Tirz and I can tolerate 4 mg Reta.

 

[Ghoul]

thats interesting so if I were to use reta year round id eventually just have the skin sens go away

Usually, most cases of GLP drug induced skin sensitivity go away after a period of continuous use, a month or so after starting or increasing the dose yeah.

In a sense, in most cases it’s a good sign.

GLP receptors exist on nearly every cell, and when activated, always seem to do something positive for health.

The TLDR for skin sensitivity’s underlying cause is GLP triggering sensory nerves to release neuropeptides. These protect nerves from oxidative (stress and aging) damage, and make nearby blood vessels relax, bringing more blood flow to the nerves.

This initially causes mild inflammation of nerve fibers, and makes the nerves function better, all of which causes hypersensitivity and / or a mild burning sensation.

The inflammation settles down within weeks and your brain recalibrates, “turning down the volume” on how it perceives the stronger signal it’s getting from these newly enhanced functioning sensory nerves, so sensation returns to normal.

In some rare cases it’s an immune response that doesn’t ease off, but that reaction can usually be distinguished by redness, heat and pain at the injection site.

 

[Eddie.]

When blood sugar rises too high, pancreatic BETA cells release INSULIN to get muscles and other tissues to absorb the excess.

When blood sugar drops too low pancreatic ALPHA cells release GLUCAGON to get the liver to dump sugar into the blood so you have enough energy to survive.

Reta’s “magic” ingredient, GLUCAGON, continuously stimulates the liver to produce and release sugar into your blood.

This helps burn off a little fat (especially liver fat), but it also raises your glucose levels continuously.

Tirz is the best of the 3 big GLP drugs for glucose control, making it, in my opinion, the best for pairing with rHGH.

Skin sensitivity sides are fairly common with Reta (Rarely it can happen with Sema and Tirz too), but often clear up after a few weeks or months.

That's interesting! So, tirz would be more beneficial for off season since high HGH and carbs lead to increased blood glucose.

I'm kinda over with reta, haven't tried tirz yet but i will soon i hope. Can't cope with the increased RHR, no med helps and it's screwing my sleep. It's terrible.

 

[Ghoul]

That's interesting! So, tirz would be more beneficial for off season since high HGH and carbs lead to increased blood glucose.

I'm kinda over with reta, haven't tried tirz yet but i will soon i hope. Can't cope with the increased RHR, no med helps and it's screwing my sleep. It's terrible.

Yeah the boosted RHR and extra energy from the slightly increased fasting blood glucose seems to overstimulate enough to disturb sleep in some users. Tirz lowering baseline glucose is enough for some sensitive users to feel mild fatigue, which Reta doesn’t cause (pushing glucose in the opposite direction, up), but if you’re using rHGH, enhanced lipolysis is saturating blood with free fatty acids as an alternative energy source that should more than make up for the slight drop in glucose caused by Tirz.

 

[mrsloppyboo]

When blood sugar rises too high, pancreatic BETA cells release INSULIN to get muscles and other tissues to absorb the excess.

When blood sugar drops too low pancreatic ALPHA cells release GLUCAGON to get the liver to dump sugar into the blood so you have enough energy to survive.

Reta’s “magic” ingredient, GLUCAGON, continuously stimulates the liver to produce and release sugar into your blood.

This helps burn off a little fat (especially liver fat), but it also raises your glucose levels continuously.

Tirz is the best of the 3 big GLP drugs for glucose control, making it, in my opinion, the best for pairing with rHGH.

Skin sensitivity sides are fairly common with Reta (Rarely it can happen with Sema and Tirz too), but often clear up after a few weeks or months.

How would tirz compare to reta in terms of keeping me insulin sensitive in a push phase?

 

[RockyP]

How would tirz compare to reta in terms of keeping me insulin sensitive in a push phase?

They’d both work. The issue for a push phase would be appetite suppression and slowed gastric emptying. You’d need to play around with each to see what you tolerate best in regard to those factors.

 

[deadbeef]

How would tirz compare to reta in terms of keeping me insulin sensitive in a push phase?

Reta is far superior than tirz for that.

 

[Lifting88]

Reta is far superior than tirz for that.

High fasted bloodsugar in a push isnt a goos thing ...is it really word to use reta in a push then

 

[deadbeef]

High fasted bloodsugar in a push isnt a goos thing ...is it really word to use reta in a push then

Do you care more about glucose control or insulin sensitivity? Tirz is better at the former. Reta is better at the latter.

 

[mrsloppyboo]

Do you care more about glucose control or insulin sensitivity? Tirz is better at the former. Reta is better at the latter.

Would I be able to use insulin (pre and post workout) along with the reta even if my fasted BG is in the 90s?

 

[krvuxn]

Would I be able to use insulin (pre and post workout) along with the reta even if my fasted BG is in the 90s?

Yes. Start low and build up. I’m using both Lantus and humalog with reta.

 

[SubparMarioBro]

When blood sugar rises too high, pancreatic BETA cells release INSULIN to get muscles and other tissues to absorb the excess.

When blood sugar drops too low pancreatic ALPHA cells release GLUCAGON to get the liver to dump sugar into the blood so you have enough energy to survive.

Reta’s “magic” ingredient, GLUCAGON, continuously stimulates the liver to produce and release sugar into your blood.

This helps burn off a little fat (especially liver fat), but it also raises your glucose levels continuously.

Tirz is the best of the 3 big GLP drugs for glucose control, making it, in my opinion, the best for pairing with rHGH.

Skin sensitivity sides are fairly common with Reta (Rarely it can happen with Sema and Tirz too), but often clear up after a few weeks or months.

Wrapped up a two-week refeed following an extended calorie deficit. Fasting labwork at the end of the calorie deficit showed glucose at 68 mg/dl and insulin at 1.4 mIU/ml. At the end of the two week refeed fasting labwork showed glucose at 90 mg/dl and insulin at 18.1 mIU/ml. Pretty damn strong response to a refeed.

 

[mrsloppyboo]

Yes. Start low and build up. I’m using both Lantus and humalog with reta.

Fasted BG was 100 today. Calories just got to 4k. Body composition is great. Starting pre workout R type insulin tomorrow. Does fasted BG truly matter if I know I am insulin sensitive?

 

[Ghoul]

Fasted BG was 100 today. Calories just got to 4k. Body composition is great. Starting pre workout R type insulin tomorrow. Does fasted BG truly matter if I know I am insulin sensitive?

Not at that low level while on a GLP. If it starts creeping up that’s a concern.