Low/effective doses of tren have surprisingly little adverse effect on blood work. In fact it lowers hgA1c and triglycerides. DHT derivates seem far worse on lipids, and test/Eq worse for hematocrit.
I run 5mg tren & trest ace ea daily, year round. The estrogen from the trest should offset any potential neurotoxicity from the potent androgens. I’ve read the studies about that, and still think much of it is related to sleep deprivation, as are many of the psych symptoms some develop with tren use (paranoia, uncontrollable anger, hostility, depression, etc). Same thing happens to coke/meth addicts who can’t sleep, and those unfortunate enough to have fatal familial insomnia.
Even at higher doses only real problem it causes me is sleep disturbance, but microdosing Seroquel/quetiapine takes care of that completely. Just 6.25 - 12.5 mg sublingual works every night… and easy to split as the (smallest) 25mg tabs from pct24x7 are double scored. No hangover, amnesia, or development of tolerance/dependency. And any cardiac issues from Seroquel use are irrelevant at that dosage.