Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

[Cimcity]

36 makes that level even worse:

I’m in a rush so going to cheat and let this sum it up. Make sure you stop rHGH asap. You’ll need 4 weeks, 5 is better, to return to baseline so it’s not elevated when they test. I wouldn’t mention you used rHGH. Complain like the symptoms have been increasing for a year or more, and a buddy recommended a hormone workup. (When they order the test, “suggest” IGF-1 since “Dr Google” suggested that might cause
your symptoms. If they don’t order it, you may want to get it on your own (just IGF-1), tell the doc your buddy pressured you to do it, and give him the results (make sure he can’t see previous ones), otherwise you may be fucking around for months before they finally test it.

——

IGF-1 of 56 in a 36-year-old: Clinical Context

1. Typical IGF-1 levels:
• For adults around 36 years old: roughly 100–300 ng/mL (lab-dependent).
• 56 is significantly below normal, suggesting low GH activity.

2. Possible causes of low IGF-1:
• Adult Growth Hormone Deficiency (AGHD) – pituitary not producing enough GH.
• Other hormonal issues – low thyroid (hypothyroidism), low sex hormones, or adrenal problems.
• Chronic illness or malnutrition – liver disease, kidney disease, severe illness.
• Medications – glucocorticoids, some chemo, or other hormone therapies.

3. Symptoms often associated with low IGF-1 / GH deficiency:
• Fatigue, low energy
• Decreased muscle mass / strength
• Increased body fat (especially around abdomen)
• Poor exercise tolerance
• Thinning skin, decreased bone density
• Mood changes, low motivation

4. Next steps typically recommended by specialists:
• Confirm the low IGF-1: repeat test to rule out lab error.
• Full pituitary hormone panel: TSH, free T4, cortisol, LH/FSH, testosterone/estradiol as applicable.
• GH stimulation testing: e.g., insulin tolerance test, arginine-GHRH, or glucagon test to confirm AGHD.
• Evaluate for underlying conditions like liver/kidney disease or malnutrition.
• Imaging: MRI of the pituitary if a deficiency is confirmed, to check for structural causes.

5. Treatment considerations:
• If AGHD is confirmed, GH replacement therapy can improve:
• Body composition (more muscle, less fat)
• Bone density
• Energy and quality of life
• Cardiovascular risk markers

Important: GH therapy is prescription-only and carefully monitored with IGF-1 levels to avoid side effects (like swelling, joint pain, insulin resistance).

Thanks for the detailed response brother. Much appreciated. I will absolutely look into it.

 

[juicebro]

Hate to be the one to break the news but the guys around here sometimes take things outside of pharma guidelines.

I was on 20mg reta. Tried taking a break and jumped back on 15mg... I don't think the appetite suppression ever comes back. I'm not just using it for the health benefits. I never needed it to drop weight.

 

[BigNate78]

I was on 20mg reta. Tried taking a break and jumped back on 15mg... I don't think the appetite suppression ever comes back. I'm not just using it for the health benefits. I never needed it to drop weight.

You were taking 20mg a week???????

 

[Ghoul]

Thanks for the detailed response brother. Much appreciated. I will absolutely look into it.

Just so you understand the full context, your IGF is in the 1st percentile. In other words, the lowest 1% of 36 year old males.

I’d say it was a testing error, but the post 4iu number makes it clear it’s not.

 

[Ghoul]

You were taking 20mg a week???????

Rookie numbers

Post in thread 'Giant Semaglutide Thread (and other GLP-1 / GIP agonists)'

Nov 15, 2025

Does anyone here take sema, tirza or reta at high dosages and have noticed a change in their urination habits?
For example, a sudden urge to urinate?

No difference.
26mg/week reta.

• Photon

• 

 

[juicebro]

You were taking 20mg a week???????

Yes and for a long time. Went from 12 to 15 then to 20. It did increase the effects for a while but then settled.

We use grams of anabolics...tren...reserach chemicals that haven't even been tested on humans. I'm okay taking a bit more GLP than they tested on people.

 

[setters]

Yes and for a long time. Went from 12 to 15 then to 20. It did increase the effects for a while but then settled.

We use grams of anabolics...tren...reserach chemicals that haven't even been tested on humans. I'm okay taking a bit more GLP than they tested on people.

But why?

 

[Ghoul]

But why?

At least with Reta, in theory, higher doses should have almost no upper limit to its ability to increase resting metabolic rate, just burning off fat via the liver, and activating brown fat. It’s a very small glucagon effect with Reta, compared to the experiments pumping straight glucagon in via IV that even 24mg is no where those doses were. Probably safer than Clen or DNP.

 

[juicebro]

But why?

I know I had some fat storage in my liver and I have a tendency to overdo everything. Why not?

 

[dcfreak]

180 for 36iu kit hahahahahahaha again fuck tracy

Yeah he is off on his pricing. There are many other better options.

And he will fucking change prices all the time, he posted the other day with higher price if you use BTC.

 

[Cimcity]

I know I had some fat storage in my liver and I have a tendency to overdo everything. Why not?

Why not is indeed the question. Everyone seems to think this “low and slow, lowest effective dose” approach is the right way to use GLPs. But more evidence seems to suggest that the highest tolerable dose is the move. Not only that but getting to the higher dose sooner than later.

I guess it does kinda go against conventional wisdom where most compounds we’re familiar with have deleterious effects that increase in strong correlation with higher doses. But these particular hormones seem to be a different story. It will definitely be interesting to see as more studies are done and more data becomes available.

 

[BigNate78]

But why?

Because life doesnt matter to him lmfao

 

[BigNate78]

At least with Reta, in theory, higher doses should have almost no upper limit to its ability to increase resting metabolic rate, just burning off fat via the liver, and activating brown fat. It’s a very small glucagon effect with Reta, compared to the experiments pumping straight glucagon in via IV that even 24mg is no where those doses were. Probably safer than Clen or DNP.

The glucugon hits hard for me and sometimes makes me hypoglycemic so ive gotta keep carbs up and im only at 3mg

 

[BigNate78]

Why not is indeed the question. Everyone seems to think this “low and slow, lowest effective dose” approach is the right way to use GLPs. But more evidence seems to suggest that the highest tolerable dose is the move. Not only that but getting to the higher dose sooner than later.

I guess it does kinda go against conventional wisdom where most compounds we’re familiar with have deleterious effects that increase in strong correlation with higher doses. But these particular hormones seem to be a different story. It will definitely be interesting to see as more studies are done and more data becomes available.

Well for one each person reacts differently. You tell someone yeah bro get that shit and run 20mg day one you might end up killing someone

 

[Cimcity]

The glucugon hits hard for me and sometimes makes me hypoglycemic so ive gotta keep carbs up and im only at 3mg

Same here, or at least something reta does is hitting me. FBG was 59 last month when I got bloods. 10mg/week

 

[juicebro]

The glucugon hits hard for me and sometimes makes me hypoglycemic so ive gotta keep carbs up and im only at 3mg

But you're a little bitch too so it makes sense.

 

[BigNate78]

But you're a little bitch too so it makes sense.

Says the guy that needs to overdose shit for it to work. Its already rotted your brain

 

[prinzmio]

hey guys, i haven't ordered in a while... what are your alternative sources now that qsc is gone...? Any tipps are greatly appreciated!

 

[nullandvoid]

The amount of effort you have put in to determining the current state of affairs is nothing short of Herculean.

 

[PiscesMoon]

The glucugon hits hard for me and sometimes makes me hypoglycemic so ive gotta keep carbs up and im only at 3mg

How long have you been taking Semaglutide, Tirzepatide, or Retatrutide?

Often people at higher dosages have been taking it for multiple years. (Like @Ghoul said for his own use case. And maybe @Photon as well.)

Well for one each person reacts differently. You tell someone yeah bro get that shit and run 20mg day one you might end up killing someone

Nobody here is telling anyone to run 20mg as a starting dose.