Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

[Ghoul]

My tracking says shipment info received and that’s all. Does that mean it shipped or label was only created?

Label only.

 

[CoachCabo]

Man, I sure hope QSC is as alive as this thread of bickering about things of total tangents.

 

[6tren]

Did something happen to this source?

 

[Juiced_lizard]

Did something happen to this source?

For security reasons our operation will be paused few days, then will resume once everything is sorted and under control, no more details will be provided, all communication channels are shut down temporary, including emails and whatsapps. I will announce the come back once everything is solved, thank you for your patience.


No need to freak out or worry about your orders, no need rumors. Not every day can be pink, QSC never failed you and will never do that. Waiting few days during hard times won’t hurt you. That's the minimum we expect from our loyal buyers.


Please do not send any more money to our wallets and accounts until I announce the comeback.


I won’t log in during this temporary period, and you won’t be able to reach us.

 

[SWFL-239]

Turns out it Wasn't from Amazon. I had placed an order from SSA and was waiting on Tracking from Tracy from a Jan 1 purchase.
I saw that both packages had my name on them and got excited for about 2 mins. I should have tempered my expectations seeing that both packages were packed the same way. Turns out SSA split my order, and Separated Tabs from PEPS, and shipped them a few days apart. Ridiculous.

Time for me to say goodbye to QSC (and my order)

..

You and bama had me hopeful but nothing popped up on informed but I got my SSA order too so good for a few months

 

[Dirthand]

Had another "plane land" "plane departure " update last couple of days on a LZ number after a couple weeks of a layover wherever the plane landed last.. Must have a small fuel tank.. keeps having to stop a lot..

 

[BamaCrazy]

You and bama had me hopeful but nothing popped up on informed but I got my SSA order too so good for a few months

My mystery package ended up being a reship of some Tirz group buy from November. I don’t follow those forums much and apparently the purity was 97% so they reshipped to everyone without notifying us there was even an issue. My last QSC Reta order is not coming. Not a huge loss compared to some.

 

[craigdt]

Anyone know when the CNY ends?

Keep getting conflicting information

 

[Ghoul]

My mystery package ended up being a reship of some Tirz group buy from November. I don’t follow those forums much and apparently the purity was 97% so they reshipped to everyone without notifying us there was even an issue. My last QSC Reta order is not coming. Not a huge loss compared to some.

A nice surprise to offset your potential loss.

 

[BamaCrazy]

A nice surprise to offset your potential loss.

Yep. And 97% is pure enough that it will still get used.

 

[AlexDavis43]

Anyone know when the CNY ends?

Keep getting conflicting information

Officially Feb 4th but some extend the celebration to Feb 12th

 

[BamaCrazy]

Anyone know when the CNY ends?

Keep getting conflicting information

1/29-2/15. But some sources will start working again on 2/5.

 

[BamaCrazy]

Officially Feb 4th but some extend the celebration to Feb 12th

View attachment 314173

I see 2/12 on some websites for the Lantern Festival, and 2/15 on others.

 

[dasking]

What tracking website are you using that is giving you all this information?

Sorry didn't get notification, USPS system

 

[dasking]

What tracking website are you using that is giving you all this information?

Last update was at noon today showing it arriving at and then leaving the LA sorting center.

 

[mok4315]

Yep. And 97% is pure enough that it will still get used.

So a weird thing about that 97% tirz. I’ve been getting tirz for my brother since last summer, and he got to the 97% kit about a month ago. As soon as he injected it, instant ISR. Like, golf ball sized. Happened with the second shot too, so I filtered the rest of the vial for him and he finished 2 more 2.5mg shots with no issue. In the off chance that it was just that vial, he injected the first shot of a new vial (same batch) yesterday. Huge reaction again. I’ll be filtering the rest of the kit for him as he goes, but I’ll be curious if you experience the same thing.
@Ghoul thoughts?

He’s also going to try tirz from a different vendor to see if he’s developed some sort of allergy to the tirz after this second vial is out.

 

[BamaCrazy]

So a weird thing about that 97% tirz. I’ve been getting tirz for my brother since last summer, and he got to the 97% kit about a month ago. As soon as he injected it, instant ISR. Like, golf ball sized. Happened with the second shot too, so I filtered the rest of the vial for him and he finished 2 more 2.5mg shots with no issue. In the off chance that it was just that vial, he injected the first shot of a new vial (same batch) yesterday. Huge reaction again. I’ll be filtering the rest of the kit for him as he goes, but I’ll be curious if you experience the same thing.
@Ghoul thoughts?

He’s also going to try tirz from a different vendor to see if he’s developed some sort of allergy to the tirz after this second vial is out.

Any chance that was Nexaph Tirz from the Raven GB? A few of my Wife’s friends have used it with no issues.

 

[LGOP528]

Buc-ees was my jam when I was stationed on the east coast. But we don’t have nice things here in the PNW.

 

[Volute]

So a weird thing about that 97% tirz. I’ve been getting tirz for my brother since last summer, and he got to the 97% kit about a month ago. As soon as he injected it, instant ISR. Like, golf ball sized. Happened with the second shot too, so I filtered the rest of the vial for him and he finished 2 more 2.5mg shots with no issue. In the off chance that it was just that vial, he injected the first shot of a new vial (same batch) yesterday. Huge reaction again. I’ll be filtering the rest of the kit for him as he goes, but I’ll be curious if you experience the same thing.
@Ghoul thoughts?

He’s also going to try tirz from a different vendor to see if he’s developed some sort of allergy to the tirz after this second vial is out.

Has it ever been characterized what the other 3% was? I was assuming it was other soluble peptides, if so, filtering wouldn't do anything. (as any filter that would pass tirz would also pass the impurity)

 

[Ghoul]

So a weird thing about that 97% tirz. I’ve been getting tirz for my brother since last summer, and he got to the 97% kit about a month ago. As soon as he injected it, instant ISR. Like, golf ball sized. Happened with the second shot too, so I filtered the rest of the vial for him and he finished 2 more 2.5mg shots with no issue. In the off chance that it was just that vial, he injected the first shot of a new vial (same batch) yesterday. Huge reaction again. I’ll be filtering the rest of the kit for him as he goes, but I’ll be curious if you experience the same thing.
@Ghoul thoughts?

He’s also going to try tirz from a different vendor to see if he’s developed some sort of allergy to the tirz after this second vial is out.

It makes perfect sense that pain would be less post filtration.

Peptide aggregates, especially large aggregates trigger an immune response.

Aggregates form most easily from degraded peptide/protein. "Degraded" peptide including denatured (unfolded and not in its proper shape), peptide broken into fragments, or impurities (chains of random amino acids) left from the manufacturing process.

I've recently been reading about the way peptide aggregates tend to remain where they're injected in sub-q injection. They sit there attracting the attention of the immune system causing inflammation and pain.

Filtration eliminates most of the aggregates, and all of the large ones, reducing the injecting site reaction.

A new batch won't demonstrate that he's "allergic" to this one. If he doesn't have an ISR to the new one it just means that one isn't as damaged, and therefore there's less "peptide junk" to stick together forming aggregates.

In any case, I think you should always filter anyway. Just because things don't rise to the level of obvious symptoms like inflammation at the injection site, they can still cause numerous problems.

One other thing that reduces aggregation and site reactions is proper dilution. If you can get the Tirz dose to .5ml, or as close as possible, there will be less of a problem.

Why do we care about protein aggregation post-subcutaneous Injection?

By understanding the potential causes of aggregation and its consequences, researchers can minimize the risk of immune responses and inflammation

www.pion-inc.com

"When administering drugs subcutaneously, larger particles or aggregates, can linger at the injection site for extended time periods, increasing the chances of interactions with immune cells. The human body's innate defense mechanisms can recognize these aggregates as potential threats, which can cause immune cells to engulf and destroy the drug, rendering it less effective."

The severity of an adverse immune reaction to a medication can vary, ranging from minor localized discomfort to potentially fatal anaphylaxis for the patient. Often immune reactions to a subcutaneous medicine will result in some amount of inflammation, which, if substantial, can cause significant pain for the patient."

Influence of Aggregation and Route of Injection on the Biodistribution of Mouse Serum Albumin - PMC

Protein aggregates are a major risk factor for immunogenicity. Until now most studies on aggregate-driven immunogenicity have focused on linking physicochemical features of the aggregates to the formation of anti-drug antibodies. Lacking is however, ...

pmc.ncbi.nlm.nih.gov