bighunanballs
Member
This is interesting, because "High Molecular Weight" (HMW) proteins can induce side effects, largely through immunogenic reactions.
However, HMWs can either be longer than intended protein chains that aren't removed during the recombinant production process, which would show up in purity tests, or aggregates, which primarily form after reconstitution.
We can see there's been an evolution in the quality of HGH from years ago, when zero dimer was a rarity, for instance. It's important to recognize what was true a decade ago is not necessarily true today.
Since we're seeing 99%+ purity tests on UGL hGH, I'd say the remaining difference between Pharma and UGL is the lack of aggregate formation prevention through the careless choice of excipients (especially PH control), substandard BAC water, excess concentration of reconstituted product, contaminated containers providing aggregate "seeds" that become the nuclei for aggregates, and general poor handling by vendors and end users.
This is unlike the differences between pharma GLPs and UGL GLPs, since pharma is recombinant and UGL is synthesized, regardless of the purity achieved, or the lack of aggregation(though this is also an issue for UGL for the same reasons as above), synthesized proteins appear as more "foreign" to the immune system than recombinant produced proteins and trigger stronger immune responses.
At the end of the day all this points to the fact that if you want to get as close to "pharma" results as you can, use what's in your control to mimic pharma.
Start with the purest HGH / peptide you can source.
Use pharma grade BAC
Reconstitute to the proper minimum dilution ratio.
Filter (even better if done per dose aka "bedside filtration" in medical terms, just before administration, but this can be a pain in the ass, though there are ways to make it more practical).
Transfer to a container that's been certified particulate free by an FDA facility (these are cheap).
Protect from heat, impact, and light by spending the extra dime on amber glass(thanks @Clover 0080) .
Try to use lower dose vials to minimize the time your peptide/HGH is in reconstituted form.
Looks like serostim says .5-1ml bac water per 4,5 & 6mg vial. Pretty big spread there. You could theoretically match this with QSC 36iu kits with only 1ml bac water
