Trenbolonetax
Member
You probably got the rat poison
MESO-Rx
Anabolic Steroids
Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic
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Ghoul
Member
Please don't take anything in this response personally, it's a reasonable question.
I use it to illustrate the absurdity of how the most basic factors don't cross the mind of people using these compounds, who are so confident making up protocols based on "feels", mixed peptide recipes, and scoff at what's taken massive amounts of effort to ensure is a safe, effective protocol.
Other factors like dosing frequency are equally significant, but this is the simplest to explain.
Reconstitution ratios affect two major factors:
First, the amount of liquid determines the pharmacokinetics, ie how quickly the dose is delivered systemically. The more liquid, the slower the rate of delivery. Cut that dose of Sema from .75ml to. .10ml, and instead of building in blood levels slowly over several hours, it'll be minutes. This intense hit of Sema can significantly increase the strength of side effects and induce transient hypoglycemia (low blood sugar).
Secondly, the more concentrated the solution is, the higher the rate of "aggregation". Aggregates are formed from peptides "sticking" together, and TLDR, they become ineffective and wasted. This gets progressively worse with time, reducing potency.
Immune response is also impacted by concentration, but too much to get into here.
For the "correct" concentrations, refer to what pharma uses. If not an approved drug, refer to the clinical trials. Finally, if it's not a pharma compound, look at what researchers are using in their studies. It tends to be uniform.
Exceeding the "correct" dilution rates isn't a significant problem, the worst impact slowing the amount of time needed to take effect. Going lower causes the problems above and should be avoided.
So, as examples:
Sema: Up to 1.4mg, .50ml per dose.
then Up to 2.4mg, .75ml per dose
Tirz: Up to 15mg, .50ml per dose
Reta: Up to 12mg, .50ml per dose
PT-141: Up to 1.75mg, .30ml per dose
HGH: No less than .05ml per iu.
Grey Spartan
Member
Sissy
Docsunshine23
Member
This poor people shopping promo stuff always confuses. How much would shipping run on 6-8 kits of HGH from promo?
Spaceman Spiff
Subscriber
You are suggesting the concentration of the drug being delivered is affecting the time of effect? Lol
This honestly sounds extremely ridiculous. Especially for hgh.
What evidence is there to support this statement?
Or even for tirzepatide? Is it just as simple as "the auto injectors are just loaded with 0.5ml?".
Clover 0080
Member
started with 5 immediately but it was pharma grade bought off someone else not written by my personal dr. But I've heard of drs actually starting people on 5 right from the jump too
Has anyone had issues with there raws being marked incorrectly? The marked numbers are not matching the serial numbers on my order. I know what tren and EQ looks like and there marked with different numbers then my order shows.. I know there are others marked incorrectly by the weights. My first time ordering from these guys so not sure if I’m looking for the wrong numbers
AlexDavis43
Member
Finding the lowest possible amount of BAC that will dilute the peptide is less likely to be a better answer than going in the other direction.
For example, yes it will dissolve in 0.6 mL but you can easily fit 2 mL in the vial. Put 2 mL in the vial unless there is a specific indication to use less.
It's still a very low injection volume, if that's what you're worried about.
For example, yes it will dissolve in 0.6 mL but you can easily fit 2 mL in the vial. Put 2 mL in the vial unless there is a specific indication to use less.
It's still a very low injection volume, if that's what you're worried about.
BP_6
Member
I know it is like this with the recent int vials. Despite what the serial number shows on the email with your order, email the rep who did your order and they will give you the real numbers.
AlexDavis43
Member
There isn't great science on this but for 10 IU vials, I add 2 mL BAC and shoot it in two 1 mL subQ shots daily.
In the absence of better evidence, I'm siding with more diluted rather than more concentrated (for other peptides too).
I had problem with an order i got yesterday.. email tracy..
R
readalot
Guest
Timing in drug absorption and disposition: The past, present, and future of chronopharmacokinetics - PMC
The importance of drug dosing time in pharmacokinetics, pharmacodynamics, and toxicity is receiving increasing attention from the scientific community. In spite of mounting evidence that circadian oscillations affect drug absorption, distribution, ...
pmc.ncbi.nlm.nih.gov
chronopharmacokinetics for more fun.
Trenbolonetax
Member
Don’t make me fuck around and find out.
AlexDavis43
Member
Timing in drug absorption and disposition: The past, present, and future of chronopharmacokinetics - PMC
The importance of drug dosing time in pharmacokinetics, pharmacodynamics, and toxicity is receiving increasing attention from the scientific community. In spite of mounting evidence that circadian oscillations affect drug absorption, distribution, ...
chronopharmacokinetics for more fun.
PTSD from one of my postdocs for sure.
thecmorgan
Member
I started at 1250mcg and upped it 1250 every 4 weeks
Ghoul
Member
Completely by coincidence, I was reading a study looking at HGH injection pain, and they consider reducing injection volume as a strategy, since sub-q injections over 1ml are known to be painful, but as I noted, high concentration speeds up degradation of peptides (and proteins) by forming aggregates.
One approach to reducing the injection volume is to increase hGH concentration. However, as mentioned previously, highly concentrated hGH formulations have higher viscosity and thus a higher risk of aggregate or insoluble particulate formation, compromising product stability and safety.
The compromised "safety" they mention is the immune reaction to the aggregates which causes immunity to HGH and even natural growth hormone to develop (this happens in about 2% of patients, who have to stop treatment. I'll bet there's an even higher percentage of people using UGL who don't realize they've developed immunity to HGH, it just "doesn't work", or they need really high doses).
They conclude that whatever the total HGH dose, it should "fit" into 0.5-.8ml, which is well above the minimum dilution of any dose (even BB doses), but also provides the right pharmacokinetics, allowing HGH to absorb into the body at the ideal rate, with minimal pain:
According to these results, injection volumes ≤ 1.0 mL are preferred, and 0.5-0.8 mL is ideal.
Frontiers | New insight into the importance of formulation variables on parenteral growth hormone preparations: potential effect on the injection-site pain
Reducing injection-site pain (ISP) in patients with chronic conditions such as growth hormone deficiency is a valuable strategy to improve patient compliance...
www.frontiersin.org
Ghoul
Member
By the way, mix two peptides in the same syringe, and you have many new ways the two peptides can "stick" to each other. This not only forms more peptide wasting aggregates, but new, never before studied aggregate shapes that will have completely untested effects on the immune system. No one is studying all the combinations a reta and sema peptide can form when attaching to each other, building new, never seen aggregates and what weird immune response that can induce. It may be many years before the effects of that "in body reddit sponsored experimentation" become clear.
This is one reason the FDA stepped in and banned compounding pharmacies from combining multiple peptides. They specifically noted the potentially catastrophic long term effects this may have.
None of this is a concern if you stick to one compound, using the pharma protocol, and a reminder not to think of peptides like AAS.
This is one reason the FDA stepped in and banned compounding pharmacies from combining multiple peptides. They specifically noted the potentially catastrophic long term effects this may have.
None of this is a concern if you stick to one compound, using the pharma protocol, and a reminder not to think of peptides like AAS.
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Grey Spartan
Member
All jokes bro. I don't want your wife hunting me down and slapping me around. lol
This is as extrapolated as stacking IMO. For one thing, pharma didn't study lyophilized, so theories about dilution mixes for these peptides are based on extrapolations. Ideally I see no reason why dilution factor would affect anything apart from injection site reactions for certain peptides (very acidic or very alkaline). Certainly not the well buffered ones.
Sounds made up to me.
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