Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

[DECLAN]

I'm still not clear on GLP1s main method that induces weight loss. Is it blunting of hunger, or through some sort of extra-metabolic work that bypasses traditional caloric balance like DNP's uncoupling? If it's both, which weighs heavier for results?

This is NOT to infer that taking GLP1 makes one lazy. I'm just curious as to what primarily causes the weight-loss.

It is one of the rising topics in YouTube for fat loss, it seems like everyone has an indepth video about it. I think j3 university actually have a discussion with a particular doctor who has done actual research about it. Search it up.

 

[mochul]

I'm still not clear on GLP1s main method that induces weight loss. Is it blunting of hunger, or through some sort of extra-metabolic work that bypasses traditional caloric balance like DNP's uncoupling? If it's both, which weighs heavier for results?

This is NOT to infer that taking GLP1 makes one lazy. I'm just curious as to what primarily causes the weight-loss.

It doesn’t effect metabolic acitovity like dnp. It imporoves it by adjusting insuline resistance. There is no reason not go take them. Great for bulking imo for controlling insuline resistance and nutrition uptake.

 

[PushPullPl8s]

They make you such a whiny biotch that all the crying and typing burns an extra 500 calories a day

Actually laughed out loud lmao

It is one of the rising topics in YouTube for fat loss, it seems like everyone has an indepth video about it. I think j3 university actually have a discussion with a particular doctor who has done actual research about it. Search it up.

Fair enough! I believe VS says he talked about them long before it was even medically available.

It doesn’t effect metabolic acitovity like dnp. It imporoves it by adjusting insuline resistance. There is no reason not go take them. Great for bulking imo for controlling insuline resistance and nutrition uptake.

Could Lantus + Berberine not achieve the same thing? Nutrition partitioning via Lantus and insulin sensitivity via berberine? I'm not contesting here, genuinely curious

 

[Ghoul]

I'm still not clear on GLP1s main method that induces weight loss. Is it blunting of hunger, or through some sort of extra-metabolic work that bypasses traditional caloric balance like DNP's uncoupling? If it's both, which weighs heavier for results?

This is NOT to infer that taking GLP1 makes one lazy. I'm just curious as to what primarily causes the weight-loss.

Oversimplified version. You know how high protein foods and high fiber foods satisfy you more than "empty carbs"? The presence of high protein and the stimulation of certain cells by fiber in the gut trigger the release of glucagon, which among a million other effects, stimulates the satiety portion of the brain.

This is also why these glucagon level increasing drugs seem to reduce alcoholism and addictions of all sorts, even gambling. It reduces "cravings". Some women complain of reduced sex drive as well.

Glucagon has a very short life. Minutes. So just like steroid esters make them last longer, the breakthrough with GLP drugs was making them last a week.

Month long lasting versions are coming soon, and a once a year shot may very well become an "obesity vaccine".

 

[jj89]

They make you such a whiny biotch that all the crying and typing burns an extra 500 calories a day

You must weigh 90lbs then

 

[Pinnacle Elements]

You must weigh 90lbs then

Good one bro, very creative

 

[mochul]

Actually laughed out loud lmao

Fair enough! I believe VS says he talked about them long before it was even medically available.

Could Lantus + Berberine not achieve the same thing? Nutrition partitioning via Lantus and insulin sensitivity via berberine? I'm not contesting here, genuinely curious

Well lantus is better but it’s not good for health. You can not overcome the insuline resistance on high dosage of lantus with berberine. You can use glp-1 with lantus too.
Health wise glp-1 are safer but not as effective as insuline.
I would assume something like short acting insuline plus glp-1 plus cardio is a good balance between bodybuilding goals and health

 

[Kdubswoldgier]

Humans can live 3 weeks without eating.

Let's say hypothetically there were no negative health effects from fasting that long.

I offer you $100,000 to not eat that long.

There's food in the house. There's a grocery store down the street.

After 1 day of not eating you'll be really hungry.

After 2 full days of no food you'll be famished.

By day 5 you'll be absolutely starving. You'd begin hallucinating about food. Dreaming about. It would occupy every thought. Think that's in your control?

By day 10 it will be absolutely impossible for you to not eat. I could raise my offer to a million, and you will break down and eat what's around you or go get something.

By day 12 you'd eat your pets. You'd kill them with your bare hands and eat them raw.

What do you call that drive to eat? Is that a "decision" you'd make to eat? A failure of willpower or morality? Or an increasingly powerful biological drive that will ultimately override your willpower, even a knuckle dragging god like creature like you.

What if something in that biological mechanism was broken and the same drive that exists at day 7 of your fast exists all the time for someone? Like people who get hiccups lasting days, or a nerve issue that causes a perpetual itch?

You're just too willfully stupid to believe, or even have the intellectual curiosity to understand the science,

Can you even eat 8000 calories a day? I bet you can't. Yet they can. If you had two brain cells you'd find that odd and ask why that might be.

If they're eating out of gluttony and selfishness, why do these drugs that raise glucagon levels and reduce appetite successfully result in weight loss for nearly 100% of people? Aren't they eating for pleasure and not out of appetite?

Bro there are tweakers on my street that would take your 'bet'
I've been there so I know can go with very lil sleep (few hours here and there during month long sexcapade run... and only eating a couple tacos a week for a month just bc needed food not bc hunger)
But now I want to get huge so I can flex on them this summer (gotta have goals)
And if fat just have to work out more... Simple shit

 

[Pinnacle Elements]

Bro there are tweakers on my street that would take your 'bet'
I've been there so I know can go with very lil sleep (few hours here and there during month long sexcapade run... and only eating a couple tacos a week for a month just bc needed food not bc hunger)
But now I want to get huge so I can flex on them this summer (gotta have goals)
And if fat just have to work out more... Simple shit

Love it. The age old story of ex-drug addict turned into a now gym addict. Atta boy.

You’re right though. That guy is just obsessed with food. Acts like none of us have ever cut before or gone a couple days without food.

 

[Hitman]

Fastest delivery to Australia to date - promo tirz and a second intl order delivered in 2 weeks!

My recent order during the GB for kits of BPC is moving just as quick, be here in a couple of days.

 

[vizzorz]

My recent order during the GB for kits of BPC is moving just as quick, be here in a couple of days.

Yeah my last one was too… keen for the HGH gb

 

[Ghoul]

Love it. The age old story of ex-drug addict turned into a now gym addict. Atta boy.

You’re right though. That guy is just obsessed with food. Acts like none of us have ever cut before or gone a couple days without food.

You act like thousands of scientists conducting decades of research are all wrong, everyone is just like you, and if they would simply choose to control themselves, the way you do, no one would be overweight. You're simply superior and no amount of evidence will dissuade you of that belief.

 

[Ghoul]

Bro there are tweakers on my street that would take your 'bet'
I've been there so I know can go with very lil sleep (few hours here and there during month long sexcapade run... and only eating a couple tacos a week for a month just bc needed food not bc hunger)
But now I want to get huge so I can flex on them this summer (gotta have goals)
And if fat just have to work out more... Simple shit

Because amphetamines weren't the original diet pill. Speed doesn't suppress appetite, they've just all coincidentally decided to focus their "self control" on eating fewer calories.

Lay off the anabolics and work to earn that body you weak willed pussy.

 

[Hitman]

Yeah my last one was too… keen for the HGH gb

Fk yeah , Im watching that poll on Discord praying the 36iu vials get over the line.
Edit . Just checked and its miles ahead.

 

[Pinnacle Elements]

if they would simply choose to control themselves, the way you do, no one would be overweight.

The irony is, this is 100% factual. You act like none of us have ever chosen to eat caloric surpluses & deficits then followed through with our intentions.

Like dude, do you know where you are? You’re in the world of fitness, exercise & nutrition. In this world we train and eat to meet goals.

 

[Pinnacle Elements]

Because amphetamines weren't the original diet pill. Speed doesn't suppress appetite, they've just all coincidentally decided to focus their "self control" on eating fewer calories.

Lay off the anabolics and work to earn that body you weak willed pussy.

Have you ever taken amphetamine? Stimulants 1000% suppress appetite lol.

 

[gotmyles]

Humans can live 3 weeks without eating.

Let's say hypothetically there were no negative health effects from fasting that long.

I offer you $100,000 to not eat that long.

There's food in the house. There's a grocery store down the street.

After 1 day of not eating you'll be really hungry.

After 2 full days of no food you'll be famished.

By day 5 you'll be absolutely starving. You'd begin hallucinating about food. Dreaming about. It would occupy every thought. Think that's in your control?

By day 10 it will be absolutely impossible for you to not eat. I could raise my offer to a million, and you will break down and eat what's around you or go get something.

By day 12 you'd eat your pets. You'd kill them with your bare hands and eat them raw.

What do you call that drive to eat? Is that a "decision" you'd make to eat? A failure of willpower or morality? Or an increasingly powerful biological drive that will ultimately override your willpower, even a knuckle dragging god like creature like you.

What if something in that biological mechanism was broken and the same drive that exists at day 7 of your fast exists all the time for someone? Like people who get hiccups lasting days, or a nerve issue that causes a perpetual itch?

You're just too willfully stupid to believe, or even have the intellectual curiosity to understand the science,

Can you even eat 8000 calories a day? I bet you can't. Yet they can. If you had two brain cells you'd find that odd and ask why that might be.

If they're eating out of gluttony and selfishness, why do these drugs that raise glucagon levels and reduce appetite successfully result in weight loss for nearly 100% of people? Aren't they eating for pleasure and not out of appetite?

i would argue that even a very sick person with a very sick liver would be producing ketones well before day 12. and not be as desperately hungry as youre talking about by that point.

on carnivore diet i would have to remind myself to eat some days. body just had no requirement for food some days.

 

[gotmyles]

I was really about to stir the pot and say that 300 lbs of solid muscle is harder on the heart than being 300 lbs of a fat body.

there is a real arguement both ways. it really depends , each example of person could have sky high or actually decent blood pressure

 

[DECLAN]

Oversimplified version. You know how high protein foods and high fiber foods satisfy you more than "empty carbs"? The presence of high protein and the stimulation of certain cells by fiber in the gut trigger the release of glucagon, which among a million other effects, stimulates the satiety portion of the brain.

This is also why these glucagon level increasing drugs seem to reduce alcoholism and addictions of all sorts, even gambling. It reduces "cravings". Some women complain of reduced sex drive as well.

Glucagon has a very short life. Minutes. So just like steroid esters make them last longer, the breakthrough with GLP drugs was making them last a week.

Month long lasting versions are coming soon, and a once a year shot may very well become an "obesity vaccine".

Show me a study where an individual becomes obese eating at maintenance.

 

[gotmyles]

Honestly guys, whether you’re team Roids or team GLP- give it 2 months and you’ll be balls deep.

I found this forum back before or at least the genesis of GLPs, hoping to find a cheaper source for BPC & other peptides I was spending too much on with peptidesciences.

Maybe a month or two later I was on Test, Primo & HGH. 8 months later I ran Tren.

So, give it time. You stick around this forum the bug will bite you. You’ll stare at that price list and justify to yourself “man I can get a lifetime of testosterone for $200”

Then next thing you know you’re on Tren A, 8% BF with frikken abdominal veins and your girlfriend is hurting from the intensity of your libido now.

i read this and just laughed really fucking hard