MESO-Rx Sponsor Primal Pharma - US Domestic

[readalot]

with that being said, with any hand filled product, there can be some small fluctuations between vials

It's a batch and a homogeneous solution (I hope). How?

 

[Photon]

When we had that batch tested, it came back at 202.37mg/mL, so it was just slightly overdosed. with that being said, with any hand filled product, there can be some small fluctuations between vials.

I believe the margin of error should be <5%.

I'm curious.
Why does it matter if its hand filled or not?
You fill more, or less, it's still mg per ml, no?
More ml, more mg total. Less ml, less mg total. but still, mg per ml.

 

[readalot]

Same batch brother

Thank you for replying. That is astonishing if both tests were on same batch.

 

[readalot]

I believe the margin of error should be <5%.

I'm curious.
Why does it matter if its hand filled or not?
You fill more, or less, it's still mg per ml, no?
More ml, more mg total. Less ml, less mg total. but still, mg per ml.

Correct.

Less than 2% on that particular test.

 

[ZenithMan]

Sent in Mast E 200mg for testing to Jano. Results came back great .

Janoshik Analytical

Thanks for testing!

 

[accidentaljedi173]

When we had that batch tested, it came back at 202.37mg/mL, so it was just slightly overdosed. with that being said, with any hand filled product, there can be some small fluctuations between vials.

Im curious to see how you can make any of this make sense.

 

[Primal_Pharma]

I believe the margin of error should be <5%.

I'm curious.
Why does it matter if its hand filled or not?
You fill more, or less, it's still mg per ml, no?
More ml, more mg total. Less ml, less mg total. but still, mg per ml.

When we mention hand-filling, we’re referring to the slight inconsistencies that can occur during the mixing and filtering process before it hits the vial. Small-batch solutions can experience micro-variability in concentration throughout the batch.

It’s about how evenly the active compound is distributed and suspended in solution across the entire batch

 

[readalot]

Im curious to see how you can make any of this make sense.

 

[ZenithMan]

Jano treats all samples as blind no matter what you write. Ive been a part of lab vs lab tests to prove this. Hes not a after hours college lab that facebook vendors use that do not provide COAs.

+10% variance isnt the worst. Especially in mast e of all the compounds.

 

[readalot]

It’s about how evenly the active compound is distributed and suspended in solution across the entire batch

Wtf? It is not suspended. It is a solution.

Batch size?

 

[readalot]

Jano treats all samples as blind no matter what you write. Ive been a part of lab vs lab tests to prove this. Hes not a after hours college lab that facebook vendors use that do not provide COAs.

+10% variance isnt the worst. Especially in mast e of all the compounds.

I am not knocking Jano.

We are supposedly taking about same batch here. Makes no sense.

 

[accidentaljedi173]

When we mention hand-filling, we’re referring to the slight inconsistencies that can occur during the mixing and filtering process before it hits the vial. Small-batch solutions can experience micro-variability in concentration throughout the batch.

It’s about how evenly the active compound is distributed and suspended in solution across the entire batch

I'm starting to think you don't know what your talking about

 

[Primal_Pharma]

Wtf? It is not suspended. It is a solution.

Batch size?

You’re right this isn’t a suspension, it’s a true solution. Poor word choice on my part, so let me clarify:

Once the compound is fully dissolved into the carrier and filtered, it should remain uniform throughout. But with small-batch brewing, especially when you’re pushing higher concentrations or dealing with compounds that are harder to keep stable (Mast E in this case) slight inconsistencies can still occur during the mixing and filtering stages before final vialing. That’s what we meant when referring to minor variance.

 

[Photon]

Correct.

Less than 2% on that particular test.

Jano actually does state 5% on his website, but that's probably for something like BU and it's probably much lower for Mast.

One possibility is that it's actually dosed at 210mg/ml, which makes 202mg/ml and 220mg/ml come in at ~5% variances.

especially when you’re pushing higher concentrations or dealing with compounds that are harder to keep stable (Mast E in this case)

Mast E 200, hard to keep stable..

 

[readalot]

micro-variability

Utter nonsense if you have a solution.

Suspension? Sure.

Basic 6th grade chemistry.

 

[Primal_Pharma]

Utter nonsense if you have a solution.

Suspension? Sure.

Basic 6th grade chemistry.

8th grade*

 

[readalot]

Jano actually does state 5% on his website, but that's probably for something like BU and it's probably much lower for Mast.

One possibility is that it's actually dosed at 210mg/ml, which makes 202mg/ml and 220mg/ml come in at ~5% variances.

Jano has given examples from HPLC. Tighter than 2%.

His method and instrument precision have been great. I have a hard time understanding these data.

 

[readalot]

8th grade*

5th.

Come on dude. Make it make sense.

 

[accidentaljedi173]

5th.

Come on dude. Make it make sense.

Why would they make sense when it could be deflected with humour.

 

[readalot]

Mast E 200, hard to keep stable