MESO-Rx Sponsor Primal Pharma - US Domestic

[crispybacon!]

Vial cap
Plenty on etsy
Id be a little concerned about reactions between that and the solvents in oil tho

https://www.etsy.com/listing/4312104527/vial-caps-for-30ml-bac-water-5-pack-caps?

I swab the top of the vial and inside the cap before I replace it. Wouldn’t seem like there’d be any interaction with oil at that point. But I’ll keep an eye on it.

 

[Ghoul]

Even low/average quality stoppers will stay sealed after many dozens of punctures, so my only protocol there is to wipe everything with 70% isopropyl alcohol and wait ~15 seconds for it to do it's thing, then I puncture the vial. I have vial seal aluminium stickers for anything that would be sitting long term, or is getting freezer storage. Never had an issue or infection after 20+ years and thousands of injections.

Just the normal joint aches and pains to be expected with each passing year…

Frontiers | 3,3′-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy

Osteoarthritis (OA) is a chronic degenerative joint disease characterized by articular cartilage destruction. The pathological mechanisms are complex; in par...

www.frontiersin.org

“Lipopolysaccharide (LPS)-induced chondrocytes… we found that LPS stimulation significantly inhibited autophagy, induced chondrocyte apoptosis and extracellular matrix (ECM) degradation…” 

When cartilage cells are exposed to cumulative amounts of endotoxin, say, from thousands of symptom free injections of small amounts of bacteria over years, they ‘turn off’ self-repair, start dying more, and break down their surrounding matrix, key features of joint damage.

 

[Mastedon]

If I'm trying to understand what percentage my mix needs to be in the syringe to eliminate PIP which way should I go about it?

By volume
.4ml of NPP200 with .6ml EQ300
NPP is 40% by volume
or
by dose
80mg NPP (same .4 x 200 as above) with 180mg EQ (same .6 x 300)
NPP is 31% by dosage

I think the latter is the correct way but I could very well be missing something.

 

[Photon]

If I'm trying to understand what percentage my mix needs to be in the syringe to eliminate PIP which way should I go about it?

By volume
.4ml of NPP200 with .6ml EQ300
NPP is 40% by volume
or
by dose
80mg NPP (same .4 x 200 as above) with 180mg EQ (same .6 x 300)
NPP is 31% by dosage

I think the latter is the correct way but I could very well be missing something.

Dont they result in the same outcome?
I use the latter, target via dose.
.4/.6

 

[AlexDavis43]

I have so much Mast P in 100mg/ml concentration, and it annoys me. I'd love to have 50% less vials @ 150mg/ml. I also like to make my own blends, and 200mg/ml is perfect for that as I typically need high concentration gear to get ratios correct, and can really only use Mast E for them typically.

I think we spoke about this before

I'm getting more and more pro-high conc gear as time passes

Easier for TRT & blasts, and requires less storage space

Decreased injection volume = more convenient and decreased chances of PIP

 

[AlexDavis43]

Even low/average quality stoppers will stay sealed after many dozens of punctures, so my only protocol there is to wipe everything with 70% isopropyl alcohol and wait ~15 seconds for it to do it's thing, then I puncture the vial. I have vial seal aluminium stickers for anything that would be sitting long term, or is getting freezer storage. Never had an issue or infection after 20+ years and thousands of injections.

I've never once seen coring, although if you're piercing a stopper hundreds of times, maybe stopper quality would be more of a consideration

So maybe useful in a very small number of scenarios

 

[Mastedon]

Dont they result in the same outcome?
I use the latter, target via dose.
.4/.6

True they result in the same outcome but I'm just trying to make my brain think of it in the "correct" way, so I was thinking dose.

I use excel so it lets me see by volume (I don't like to pin more than 1ml oil any day) but also what my daily/weekly dose is.

Thank you!

 

[Mastedon]

I'm getting more and more pro-high conc gear as time passes

Decreased injection volume = more convenient and decreased chances of PIP

I think the higher conc gear = increased chances of PIP

 

[Primal_Pharma]

The ment was included in the sale when it started, now excluded, unfortunately.

@Primal_Pharma are either the test P200 or the test U250 sporting new hardware? Just curious, it's a sick deal/sale regardless

P100 and U250 is!

 

[CHIEF M]

Is pharma grade truly worth the extra ? LIke Pfizer Nglena pens or cinnatropin better than generic? some people say like 2iu of those = like 6iu generic.

I’m just using the pen itself and filling carts up with my GH easier process for pinning and tbh I don’t notice much difference Btwn pharma and generic tbh

 

[AlexDavis43]

I think the higher conc gear = increased chances of PIP

In my experience the risk is offset by the lower injection volume

 

[AllGoodThings]

Just the normal joint aches and pains to be expected with each passing year…

Frontiers | 3,3′-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy

Osteoarthritis (OA) is a chronic degenerative joint disease characterized by articular cartilage destruction. The pathological mechanisms are complex; in par...

www.frontiersin.org

“Lipopolysaccharide (LPS)-induced chondrocytes… we found that LPS stimulation significantly inhibited autophagy, induced chondrocyte apoptosis and extracellular matrix (ECM) degradation…” 

When cartilage cells are exposed to cumulative amounts of endotoxin, say, from thousands of symptom free injections of small amounts of bacteria over years, they ‘turn off’ self-repair, start dying more, and break down their surrounding matrix, key features of joint damage.

That's interesting information, thank you.

I actually just saw a rheumatologist and she ruled out several forms of arthritis and a few other possible causes besides the statin, and I'm now waiting for the HMGCR test to come back to see how to proceed with treatment. Current best guess is patellar tendonitis exacerbated by statin use and iron deficiency anemia.

 

[Braxxii]

has the raw shortage situation improved anything the last few weeks? I want Drostalone Enanthate

 

[ChoZeN1]

has the raw shortage situation improved anything the last few weeks? I want Drostalone Enanthate

has the raw shortage situation improved anything the last few weeks? I want Drostalone Enanthate

Send me $1000 right now and I can get you 100gs of drostalone e. $800 + shipping.

 

[Tr3nbal0n3]

These guys send order confirmation Emails ????

 

[JBird99]

These guys send order confirmation Emails ????

they usually do shortly after

 

[Zebedee]

I've never once seen coring, although if you're piercing a stopper hundreds of times, maybe stopper quality would be more of a consideration

So maybe useful in a very small number of scenarios

Neither have I.

To a degree at least, the number of times you draw through a stopper can be irrelevant because you don’t have to put tv needle through the centre “bullseye” of the stopper. Assuming the seal allows for it, you have a much larger area outside of the bullseye & you can move around the outside of the stopper in a clock face manner.

I’ve done this from Day 1, which is almost certainly why I’ve never seen coring.

Forum guys hate the all metal flip-up & tear-off style seals, but those allow great access to a much larger stopper surface area than some flip offs.

 

[Ghoul]

Patient Safety Alert: Urgent Alert Regarding Medication Vial Coring and Fragmentation Risks

Issued by: Anesthesia Patient Safety Foundation (APSF) and ECRI/Institute for Safe Medication Practices (ISMP) APSF and ECRI/ISMP have received several reports recently of medication vial coring incidents. Coring occurs when a piece of the flexible stopper on a medication vial detaches during...

home.ecri.org

ALERT: Medication Vial Coring Poses Potential Fragmentation Risks

ALERT: Medication Vial Coring Poses Potential Fragmentation Risks; Two patient safety groups have issued an alert about the potential for injecting fragments of flexible stoppers on medication vials into patients - Outpatient Surgery Magazine.

www.aorn.org

 

[AllbrandNew]

Just bought a novo 4 pen for my GH injections now and have another pen for various peptides

I am super interested to see how you like it/what you think. I kind want to jump on the pen wagon for GH at least, and am really of the do it right the first time, so you gotta share your thoughts somewhere when you have some time on it.

 

[BigDadd7]

Patient Safety Alert: Urgent Alert Regarding Medication Vial Coring and Fragmentation Risks

Issued by: Anesthesia Patient Safety Foundation (APSF) and ECRI/Institute for Safe Medication Practices (ISMP) APSF and ECRI/ISMP have received several reports recently of medication vial coring incidents. Coring occurs when a piece of the flexible stopper on a medication vial detaches during...

home.ecri.org

ALERT: Medication Vial Coring Poses Potential Fragmentation Risks

ALERT: Medication Vial Coring Poses Potential Fragmentation Risks; Two patient safety groups have issued an alert about the potential for injecting fragments of flexible stoppers on medication vials into patients - Outpatient Surgery Magazine.

www.aorn.org

Who is using 18 gauge?! Ouch